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Prof.dr. A. Hofman Person

Prof.dr. A. Hofman

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  • Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study (2008)

    Authors:Richards, J.B. (Brent); Rivadeneira Ramirez, F. (Fernando); Inouye, M. (Michael); Pastinen, T.; Soranzo, N. (Nicole); Wilson, S.G. (Scott); Andrew, T. (Toby); Falchi, M. (Mario); Gwilliam, R. (Rhian); Ahmadi, K.R. (Kourosh); Valdes, A.M.; Arp, P.P. (Pascal); Whittaker, P.; Verlaan, D.J. (Dominique); Jhamai, M. (Mila); Kumanduri, V.; Moorhouse, M.J. (Michael); Meurs, van J.B.J.; Hofman, A. (Albert); Pols, H.A.P. (Huibert); Hart, D.J.; Zhai, G. (Guangju); Kato, B.S.; Mullin, B.; Zhang, F. (Feng); Deloukas, P. (Panagiotis); Uitterlinden, A.G. (André); Spector, T.D. (Timothy)
    In:The Lancet, 371(9623), 1505 - 1512. ISSN 0140-6736.

    Abstract:

    Background: Osteoporosis is diagnosed by the measurement of bone mineral density, which is a highly heritable and multifactorial trait. We aimed to identify genetic loci that are associated with bone mineral density. Methods: In this genome-wide association study, we identified the most promising of

  • Renin-angiotensin system inhibitors, angiotensin I-converting enzyme gene insertion/deletion polymorphism, and cancer: The Rotterdam study (2008)

    Authors:Knaap, van der R. (Ronald); Siemes, C. (Claire); Coebergh, J.W.W. (Jan Willem); Tikka-Kleemola, P. (Päivi); Hofman, A. (Albert); Stricker, B.H.Ch. (Bruno)
    In:Cancer, 112(4), 748 - 757. ISSN 0008-543x.

    Abstract:

    BACKGROUND. Angiotensin I-converting enzyme (ACE) inhibitors, angiotensin II antagonists, and the ACE insertion/deletion (I/D) gene polymorphism all influence serum angiotensin II action. Because angiotensin II levels have been associated with cancer, the objective of the current epidemiologic study

  • Three Genome-wide Association Studies and a Linkage Analysis Identify HERC2 as a Human Iris Color Gene (2008)

    Authors:Kayser, M. (Manfred); Liu, F. (Fan); Janssens, A.C.J.W. (Cécile); Rivadeneira Ramirez, F. (Fernando); Lao, O. (Oscar); Duijn, van K. (Kate); Vermeulen, M. (Mark); Arp, P.P. (Pascal); Jhamai, M. (Mila); IJcken, van W.F.J. (Wilfred); Dunnen, den J.T. (Johan); Heath, S.C. (Simon); Zelenika, D. (Diana); Despriet, D.D.G. (Dominique); Klaver, C.C.W. (Caroline); Vingerling, J.R. (Hans); Jong, de P.T.V.M. (Paulus); Hofman, A. (Albert); Aulchenko, Y.S. (Yurii); Uitterlinden, A.G. (André); Oostra, B.A. (Ben)
    In:American Journal of Human Genetics, 82(2), 411 - 423. ISSN 0002-9297.

    Abstract:

    Human iris color was one of the first traits for which Mendelian segregation was established. To date, the genetics of iris color is still not fully understood and is of interest, particularly in view of forensic applications. In three independent genome-wide association (GWA) studies of a total of

  • Fetal hemodynamic adaptive changes related to intrauterine growth the generation R study (2008)

    Authors:Verburg, B.O. (Bero Olof); Jaddoe, V.W.V. (Vincent); Wladimiroff, J.W. (Juriy); Hofman, A. (Albert); Witteman, J.C.M. (Jacqueline); Steegers-Theunissen, R.P.M. (Regine)
    In:Circulation (Baltimore), 117(5), 649 - 659. ISSN 0009-7322.

    Abstract:

    Background-It has been suggested that an adverse fetal environment increases susceptibility to hypertension and cardiovascular disease in adult life. This increased risk may result from suboptimal development of the heart and main arteries in utero and from adaptive cardiovascular changes in conditi

  • Estrogen receptor α polymorphisms and postmenopausal breast cancer risk (2008)

    Authors:González-Zuloeta Ladd, A.M. (Angela); Vásquez, A.A. (Arias); Rivadeneira Ramirez, F. (Fernando); Siemes, C. (Claire); Hofman, A. (Albert); Stricker, B.H.Ch. (Bruno); Pols, H.A.P. (Huibert); Uitterlinden, A.G. (André); Tikka-Kleemola, P. (Päivi)
    In:Breast Cancer Research and Treatment, 107(3), 415 - 419. ISSN 0167-6806.

    Abstract:

    Background: The estrogen receptor alpha (ESR1) is a mediator of estrogen response in the breast. The most studied variants in this gene are the PvuII and XbaI polymorphisms, which have been associated to lower sensitivity to estrogen. We evaluated whether these polymorphisms were associated with bre

  • Apolipoprotein E gene is related to mortality only in normal weight individuals: The Rotterdam study (2008)Open access

    Authors:Pardo Silva, M.C.; Janssens, A.C.J.W. (Cécile); Hofman, A. (Albert); Witteman, J.C.M. (Jacqueline); Tikka-Kleemola, P. (Päivi)
    In:European Journal of Epidemiology, 23(2), 135 - 142. ISSN 0393-2990.

    Abstract:

    Objective: To investigate the relationship between the apolipoprotein E (APOE) gene and the risk of mortality in normal weight, overweight and obese individuals. Methods and Results: In a population-based study of 7,983 individuals aged 55 years and older, we compared the risks of all-cause and coro

  • Kidney function is related to cerebral small vessel disease (2008)

    Authors:Ikram, M.A. (Mohammed Arfan); Vernooij, M.W. (Meike); Hofman, A. (Albert); Niessen, W.J. (Wiro); Lugt, van der A. (Aad); Breteler, M.M.B. (Monique)
    In:Stroke, 39(1), 55 - 61. ISSN 0039-2499.

    Abstract:

    BACKGROUND AND PURPOSE - Poor kidney function, as measured by glomerular filtration rate (GFR), is closely associated with presence of glomerular small vessel disease. Given the hemodynamic similarities between the vascular beds of the kidney and the brain, we hypothesized an association between kid

  • Incidental findings on brain MRI in the general population (2007)

    Authors:Vernooij, M.W. (Meike); Ikram, M.A. (Mohammed Arfan); Tanghe, H.L.J. (Hervé); Vincent, A.J.P.E. (Arnoud); Hofman, A. (Albert); Krestin, G.P. (Gabriel); Niessen, W.J. (Wiro); Breteler, M.M.B. (Monique); Lugt, van der A. (Aad)
    In:New England Journal of Medicine, 357(18), 1821 - 1828. ISSN 0028-4793.

    Abstract:

    Background: Magnetic resonance imaging (MRI) of the brain is increasingly used both in research and in clinical medicine, and scanner hardware and MRI sequences are continually being improved. These advances are likely to result in the detection of unexpected, asymptomatic brain abnormalities, such

  • The female advantage in cardiovascular disease: Do vascular beds contribute equally? (2007)

    Authors:Kardys, I. (Isabella); Vliegenthart, R. (Rozemarijn); Oudkerk, M. (Matthijs); Hofman, A. (Albert); Witteman, J.C.M. (Jacqueline)
    In:American Journal of Epidemiology, 166(4), 403 - 412. ISSN 0002-9262.

    Abstract:

    The female advantage in coronary heart disease occurrence is not completely understood. To characterize gender differences in cardiovascular disease by vascular site, the authors compared degrees of coronary, carotid, peripheral, and aortic atherosclerosis in men and women aged ≥55 years from the po

  • Maternal smoking and fetal growth characteristics in different periods of pregnancy: The Generation R Study (2007)

    Authors:Jaddoe, V.W.V. (Vincent); Verburg, B.O. (Bero Olof); Ridder, de M.A.J. (Maria); Hofman, A. (Albert); Mackenbach, J.P. (Johan); Moll, H.A. (Henriëtte); Steegers-Theunissen, R.P.M. (Regine); Witteman, J.C.M. (Jacqueline)
    In:American Journal of Epidemiology, 165(10), 1207 - 1215. ISSN 0002-9262.

    Abstract:

    The authors examined the associations of maternal smoking in pregnancy with various fetal growth characteristics among 7,098 pregnant women participating in the Generation R Study (2002-2006), a population-based prospective cohort study of pregnant women and their children in Rotterdam, the Netherla

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