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Prof.dr. A. Hofman Person

Prof.dr. A. Hofman

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  • Inappropriate benzodiazepine use in older adults and the risk of fracture (2008)

    Authors:Hooft, van der C.S. (Cornelis); Schoofs, M.W.C.J. (Marlette); Ziere, G.; Hofman, A. (Albert); Pols, H.A.P. (Huibert); Sturkenboom, M.C.J.M. (Miriam); Stricker, B.H.Ch. (Bruno)
    In:British Journal of Clinical Pharmacology, 66(2). ISSN 0306-5251.

    Abstract:

    AIMS: The Beers criteria for prescribing in elderly are well known and used for many drug utilization studies. We investigated the clinical value of the Beers criteria for benzodiazepine use, notably the association between inappropriate use and risk of fracture. METHODS: We performed a nested case-

  • High free thyroxine levels are associated with QTc prolongation in males (2008)

    Authors:Noord, van C. (Charlotte); Deure, van der W.M. (Wendy); Sturkenboom, M.C.J.M. (Miriam); Straus, S.M. (Sabine); Hofman, A. (Albert); Visser, T.J. (Ton); Kors, J.A. (Jan); Witteman, J.C.M. (Jacqueline); Stricker, B.H.Ch. (Bruno)
    In:Journal of Endocrinology, 198(1), 253 - 260. ISSN 0022-0795.

    Abstract:

    The literature on the effect of excess thyroid hormone on ventricular repolarization is controversial. To study whether free thyroxine (T4) and TSH are associated with QTc prolongation we conducted population-based cohort study. This study was conducted as part of the Rotterdam Study and included 36

  • Re: "Epidemiologic interactions, complexity, and the lonesome death of Max Von Pettenkofer" (2008)

    Authors:Wildner, M. (Manfred); Hofman, A. (Albert)
    In:American Journal of Epidemiology, 168(1), 119 - 120. ISSN 0002-9262.

  • Explaining Educational Inequalities in Preterm Birth. The Generation R Study (2008)Open access

    Authors:Jansen, P.W. (Pauline); Tiemeier, H. (Henning); Jaddoe, V.W.V. (Vincent); Hofman, A. (Albert); Steegers, E.A.P. (Eric); Verhulst, F.C. (Frank); Mackenbach, J.P. (Johan); Raat, H. (Hein)
    In:Archives of Disease in Childhood: an international peer-reviewed journal for health professionals and researchers covering conception to adolescence, 1 - 23. ISSN 0003-9888.

    Abstract:

    BACKGROUND: Although a low socioeconomic status has consistently been associated with an increased risk of preterm birth, little is known about the pathways through which socioeconomic disadvantage influences preterm birth. AIM: To examine mechanisms that might underlie the association between the e

  • Genome-wide Association Scan Identifies a Prostaglandin-Endoperoxide Synthase 2 Variant Involved in Risk of Knee Osteoarthritis (2008)

    Authors:Valdes, A.M. (Ana Maria); Loughlin, J. (John); Timms, K.M. (Kirsten); Meurs, van J.J.B. (Joyce); Southam, L. (Lorraine); Wilson, S.G. (Scott); Doherty, S. (Sally); Lories, R.J. (Rik); Luyten, F.P. (Frank); Gutin, A. (Alexander); Abkevich, V. (Victor); Ge, D. (Dongliang); Hofman, A. (Albert); Uitterlinden, A.G. (André); Hart, D.J. (Deborah); Zhang, F. (Feng); Zhai, G. (Guangju); Egli, R.J. (Rainer); Lanchbury, J. (Jerry); Spector, T.D. (Timothy)
    In:American Journal of Human Genetics, 82(6), 1231 - 1240. ISSN 0002-9297.

    Abstract:

    Osteoarthritis (OA), the most prevalent form of arthritis in the elderly, is characterized by the degradation of articular cartilage and has a strong genetic component. Our aim was to identify genetic variants involved in risk of knee OA in women. A pooled genome-wide association scan with the Illum

  • Host polymorphisms in interleukin 4, complement factor H, and C-reactive protein associated with nasal carriage of Staphylococcus aureus and occurrence of boils (2008)

    Authors:Emonts, M. (Marieke); Uitterlinden, A.G. (André); Nouwen, J.L. (Jan); Kardys, I. (Isabella); Maat, de M.P.M. (Moniek); Melles, D.C. (Damian); Witteman, J.C.M. (Jacqueline); Jong, de P.T.V.M. (Paulus); Verbrugh, H.A. (Henri); Hofman, A. (Albert); Hermans, P.W.M. (Peter); Belkum, van A.F. (Alex)
    In:The Journal of Infectious Diseases, 197(9), 1244 - 1253. ISSN 0022-1899.

    Abstract:

    Background. Staphylococcus aureus is capable of persistently colonizing the vestibulum nasi. We hypothesized that polymorphisms in host inflammatory response genes and genetic variation in S. aureus contribute to susceptibility to S. aureus carriage and infection. Methods. The prevalence of persiste

  • Coffee consumption and coronary calcification: The Rotterdam coronary calcification study (2008)

    Authors:Woudenbergh, van G.J. (Geertruida); Vliegenthart, R. (Rozemarijn); Rooij, van F.J.A. (Frank); Hofman, A. (Albert); Oudkerk, M. (Matthijs); Witteman, J.C.M. (Jacqueline); Geleijnse, J.M. (Marianne)
    In:Arteriosclerosis, Thrombosis, and Vascular Biology, 28(5), 1018 - 1023. ISSN 1079-5642.

    Abstract:

    BACKGROUND - The role of coffee in the cardiovascular system is not yet clear. We examined the relation of coffee intake with coronary calcification in a population-based cohort. METHODS AND RESULTS - The study involved 1570 older men and women without coronary heart disease who participated in the

  • Unrecognized myocardial infarction in relation to risk of dementia and cerebral small vessel disease (2008)Open access

    Authors:Arfan Ikram, M.; Oijen, van M. (Marieke); Jong, de F.J. (Frank Jan); Kors, J.A. (Jan); Hofman, A. (Albert); Koudstaal, P.J. (Peter); Witteman, J.C.M. (Jacqueline); Breteler, M.M.B. (Monique)
    In:Stroke, 39(5), 1421 - 1426. ISSN 0039-2499.

    Abstract:

    BACKGROUND AND PURPOSE: Men, but not women, with unrecognized myocardial infarction (MI) have an increased risk of cardiac events and stroke compared with those without MI or with recognized MI. We investigated whether unrecognized MI is also a risk factor for dementia and cerebral small vessel dise

  • Influence of the CYP2D6*4 polymorphism on dose, switching and discontinuation of antidepressants (2008)

    Authors:Bijl, M.J. (Monique); Visser, L.E. (Loes); Hofman, A. (Albert); Vulto, A.G. (Arnold); Gelder, van T. (Teun); Stricker, B.H.Ch. (Bruno); Schaik, van R.H.N. (Ron)
    In:British Journal of Clinical Pharmacology, 65(4), 558 - 564. ISSN 0306-5251.

    Abstract:

    Aims: To study the effect of CYP2D6*4 on antidepressant dose, switching and discontinuation of therapy. Methods: The study consisted of all subjects in the Rotterdam Study, who received a first antidepressant prescription between April 1st 1991 and July 1st 2005 and for whom data on CYP2D6 genotype

  • Vitamin K epoxide reductase complex subunit 1 (VKORC1) polymorphism and aortic calcification: The Rotterdam study (2008)

    Authors:Teichert, M. (Martina); Visser, L.E. (Loes); Schaik, van R.H.N. (Ron); Hofman, A. (Albert); Uitterlinden, A.G. (André); Smet, de P.A. (Peter); Witteman, J.C.M. (Jacqueline); Stricker, B.H.Ch. (Bruno)
    In:Arteriosclerosis, Thrombosis, and Vascular Biology, 28(4), 771 - 776. ISSN 1079-5642.

    Abstract:

    OBJECTIVE - Besides effects on hemostasis, vitamin K-dependent proteins play a role in bone mineralization and arterial calcification. We investigated the association between the VKORC1 1173C>T polymorphism and calcification of the aortic far wall in a large population-based cohort. METHODS AND RESU

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