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Prof.dr. M.M.B. Breteler Person

Prof.dr. M.M.B. Breteler

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  • The Glu318Gly substitution in presenilin 1 is not causally related to Alzheimer disease (1999)Open access

    Authors:Dermaut, B. (Bart); Cruts, M. (Marc); Slooter, A.J.C. (Arjen); Gestel, van S.; Jonghe, de C. (Chris); Vanderstichele, H.M.J. (Hugo); Vanmechelen, E. (Eugeen); Breteler, M.M.B. (Monique); Duijn, van C.M. (Cock); Broeckhoven, van C. (Christine); Hofman, A. (Albert)
    In:American Journal of Human Genetics. ISSN 0002-9297.

  • Socioeconomic differences in stroke among Dutch elderly women: the Rotterdam Study (1999)Open access

    Authors:Rossum, van C.T.M. (Caroline); Mheen, van de H. (Dike); Breteler, M.M.B. (Monique); Grobbee, D.E. (Diederick); Mackenbach, J.P. (Johan)
    In:Stroke, 30(2), 357 - 362. ISSN 0039-2499.

    Abstract:

    BACKGROUND AND PURPOSE: We sought to assess the association between socioeconomic status and the risk of stroke among elderly women. Methods--The association between socioeconomic status and stroke emerged in cross-sectional and longitudinal data on 4274 female particip

  • A prospective study on cortisol, dehydroepiandrosterone sulfate, and cognitive function in the elderly (1998)Open access

    Authors:Kalmijn, S. (Sandra); Launer, L.J. (Lenore); Stolk, R.P. (Ronald); Jong, de F.H. (Frank); Pols, H.A.P. (Huibert); Breteler, M.M.B. (Monique); Lamberts, S.W.J. (Steven); Hofman, A. (Albert)
    In:Journal of Clinical Endocrinology and Metabolism. ISSN 0021-972x.

    Abstract:

    The objective of this study was to investigate the relation between the peripheral concentrations of the adrenal steroid hormones cortisol and dehydroepiandrosterone sulfate (DHEAS) and cognitive impairment and decline. A prospective study design was used. The setting w

  • Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study (1998)Open access

    Authors:Slooter, A.J.C. (Arjen); Cruts, M. (Marc); Kalmijn, S. (Sandra); Breteler, M.M.B. (Monique); Duijn, van C.M. (Cock); Broeckhoven, van C. (Christine); Hofman, A. (Albert)
    In:Archives of Neurology, 964 - 968. ISSN 0003-9942.

    Abstract:

    OBJECTIVES: To provide risk estimates of dementia and Alzheimer disease as a function of the apolipoprotein E (APOE) genotypes and to assess the proportion of dementia that is attributable to the APOE genotypes. DESIGN: Case-control study nested in a population-based cohort study with a mean (SD) fo

  • Atherosclerosis, apolipoprotein E and the prevalence of dementia and Alzheimer's disease in a population-based study: the Rotterdam Study (1997)Open access

    Authors:Ott, A. (Alewijn); Bots, M.L. (Michiel); Slooter, A.J.C. (Arjen); Harskamp, van F. (Frans); Duijn, van C.M. (Cock); Grobbee, D.E. (Diederick); Breteler, M.M.B. (Monique); Broeckhoven, van C. (Christine); Hofman, A. (Albert)
    In:The Lancet, 349, 151 - 154. ISSN 0140-6736.

    Abstract:

    BACKGROUND: Vascular disorders have been implicated in dementia, but whether atherosclerosis is related to the most frequent type of dementia, Alzheimer's disease, is not known. The apolipoprotein-E genotype has been associated with Alzheimer's disease, and we postulate that it plays a part, togethe

  • Apolipoprotein E ε 4 and the risk of dementia with stroke. A population-based investigation. (1997)Open access

    Authors:Slooter, A.J.C. (Arjen); Tang, M-X. (Ming-Xin); Duijn, van C.M. (Cock); Stern, Y. (Yaakov); Ott, A. (Alewijn); Bell, K. (Karen); Tatemichi, T.K. (Thomas); Tycko, B. (Benjamin); Mayeux, R. (Richard); Breteler, M.M.B. (Monique); Broeckhoven, van C. (Christine); Hofman, A. (Albert)
    In:J A M A: The Journal of the American Medical Association, 277(10), 818 - 821. ISSN 0098-7484.

    Abstract:

    OBJECTIVE: To investigate the association between the apolipoprotein E (APOE) genotypes and dementia in patients with stroke, defined as either vascular dementia (VaD) or Alzheimer disease with cerebrovascular disease (AD with CVD). DESIGN AND SETTING: Population-based, case-control study from Rotte

  • APOE genotyping in differential diagnosis of Alzheimer's disease. (1996)Open access

    Authors:Slooter, A.J.C. (Arjen); Ott, A. (Alewijn); Duijn, van C.M. (Cock); Breteler, M.M.B. (Monique); Broeckhoven, van C. (Christine)
    In:The Lancet, 348(9023), 334 - 334. ISSN 0140-6736.

    Abstract:

    Letter

  • Cognitive decline in the elderly : epidemiologic studies on cognitive function and dementia (1993)Open access

    Author:Breteler, M.M.B.

    Abstract:

    In the last decades, the awareness has grown among the public, as well as among health politicians, that dementia is highly prevalent in older age, that it causes much distress to patients and their families, and that it poses a large burden on public health care resources.Initially, research focuse

  • Epidemiology of Alzheimer's disease (1992)Open access

    Authors:Claus, J.; Duijn, van C.M. (Cock); Launer, L.J. (Lenore); Breteler, M.M.B. (Monique); Hofman, A. (Albert)
    In:Epidemiologic Reviews, 14, 59 - 82. ISSN 0193-936x.

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