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Prof.dr. A. Hofman Persoon

Prof.dr. A. Hofman

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  • Blood pressure, atherosclerosis, and the incidence of age-related maculopathy: the Rotterdam Study (2003)Open access

    Auteurs:Leeuwen, van R. (Redmer); Ikram, M.K. (Kamran); Vingerling, J.R. (Hans); Witteman, J.C.M. (Jacqueline); Jong, de P.T.V.M. (Paulus); Hofman, A. (Albert)
    In:Investigative Ophthalmology & Visual Science. ISSN 0146-0404.

    Samenvatting:

    PURPOSE: To determine whether blood pressure and subclinical atherosclerosis are associated with incident age-related maculopathy (ARM). METHODS: The study was performed within the Rotterdam Study, a population-based, prospective cohort study in Rotterdam, The Netherlands. A

  • Relationship between refraction and prevalent as well as incident age-related maculopathy: the Rotterdam Study (2003)Open access

    Auteurs:Ikram, M.K. (Kamran); Leeuwen, van R. (Redmer); Vingerling, J.R. (Hans); Jong, de P.T.V.M. (Paulus); Hofman, A. (Albert)
    In:Investigative Ophthalmology & Visual Science. ISSN 0146-0404.

    Samenvatting:

    PURPOSE: To study the relationship between baseline spherical equivalents (SphE) of refraction and prevalent as well as incident age-related maculopathy (pARM and iARM, respectively). METHODS: The study was performed as part of the Rotterdam Study, a population-based, prospective

  • Incidence, risk, and case fatality of first ever stroke in the elderly population. The Rotterdam Study (2003)Open access

    Auteurs:Hollander, M. (Monika); Koudstaal, P.J. (Peter); Bots, M.L. (Michiel); Grobbee, D.E. (Diederick); Breteler, M.M.B. (Monique); Hofman, A. (Albert)
    In:Journal of Neurology, Neurosurgery and Psychiatry: an international peer-reviewed journal for health professionals and researchers in all areas of neurology and neurosurgery. ISSN 0022-3050.

    Samenvatting:

    OBJECTIVE: To estimate the incidence, survival, and lifetime risk of stroke in the elderly population. METHODS: The authors conducted a study in 7,721 participants from the population based Rotterdam Study who were free from stroke at baseline (1990-1993) and were followed up for s

  • Silent brain infarcts and the risk of dementia and cognitive decline (2003)Open access

    Auteurs:Vermeer, S.E. (Sarah); Prins, N.D. (Niels); Heijer, den T. (Tom); Koudstaal, P.J. (Peter); Breteler, M.M.B. (Monique); Hofman, A. (Albert)
    In:New England Journal of Medicine. ISSN 0028-4793.

    Samenvatting:

    BACKGROUND: Silent brain infarcts are frequently seen on magnetic resonance imaging (MRI) in healthy elderly people and may be associated with dementia and cognitive decline. METHODS: We studied the association between silent brain infarcts and the risk of dementia and cognitive

  • Spatial QRS-T angle predicts cardiac death in a general population (2003)Open access

    Auteurs:Kardys, I. (Isabella); Kors, J.A. (Jan); Kuip, van der D.A. (Deirdre); Witteman, J.C.M. (Jacqueline); Hofman, A. (Albert)
    In:European Heart Journal. ISSN 0195-668x.

    Samenvatting:

    AIMS: The aim of this study was to assess the prognostic importance of the spatial QRS-T angle for fatal and non-fatal cardiac events. METHODS AND RESULTS: Electrocardiograms (ECGs) were recorded in 6134 men and women aged 55 years and over from the prospective population-based Rot

  • Mutations in the hemochromatosis gene (HFE) and stroke (2002)Open access

    Auteurs:Njajou, O.T. (Omer); Hollander, M. (Monika); Koudstaal, P.J. (Peter); Hofman, A. (Albert); Duijn, van C.M. (Cock); Witteman, J.C.M. (Jacqueline); Breteler, M.M.B. (Monique)
    In:Stroke, 33(10), 2363 - 2366. ISSN 0039-2499.

    Samenvatting:

    BACKGROUND AND PURPOSE: Increased serum iron is found to be a risk factor for stroke. Carriers of HFE C282Y and H63D mutations have elevated serum iron levels and may have an increased risk for stroke. We studied the association between HFE gene mutations, carotid atherosclerosis, and stroke. METHOD

  • Vitamin B12, folate, and homocysteine in depression: the Rotterdam Study (2002)Open access

    Auteurs:Tiemeier, H. (Henning); Tuijl, van H.R. (Ruud); Meijer, J. (John); Kiliaan, A.J. (Amanda); Breteler, M.M.B. (Monique); Hofman, A. (Albert)
    In:The American Journal of Psychiatry. ISSN 0002-953x.

    Samenvatting:

    OBJECTIVE: The associations of vitamin B(12), folate, and homocysteine with depression were examined in a population-based study. METHOD: The authors screened 3,884 elderly people for depressive symptoms. Subjects with positive screening results had psychiatric workups. Folate, vit

  • Cerebral haemodynamics and depression in the elderly (2002)Open access

    Auteurs:Tiemeier, H. (Henning); Bakker, S.L.M. (Stef); Koudstaal, P.J. (Peter); Breteler, M.M.B. (Monique); Hofman, A. (Albert)
    In:Journal of Neurology, Neurosurgery and Psychiatry: an international peer-reviewed journal for health professionals and researchers in all areas of neurology and neurosurgery. ISSN 0022-3050.

    Samenvatting:

    BACKGROUND: Evidence from epidemiological and neuroimaging studies suggests that cerebrovascular disease is associated with depressive disorders in the elderly, but the extent to which it contributes to the pathogenesis of late life depression is unclear. OBJECTIVE: To investigate

  • Pharmacologic agents associated with a preventive effect on Alzheimer's disease: a review of the epidemiologic evidence (2002)Open access

    Auteurs:Veld, in 't B.A.; Launer, L.J. (Lenore); Breteler, M.M.B. (Monique); Stricker, B.H.Ch. (Bruno); Hofman, A. (Albert)
    In:Epidemiologic Reviews. ISSN 0193-936x.

  • The role of hemochromatosis C282Y and H63D gene mutations in type 2diabetes: findings from the Rotterdam Study and meta-analysis (2002)Open access

    Auteurs:Njajou, O.T. (Omer); Alizadeh, B.Z. (Behrooz); Vaessen, N. (Norbert); Vergeer, J.M. (Jeanette); Houwing-Duistermaat, J.J. (Jeanine); Hofman, A. (Albert); Pols, H.A.P. (Huibert); Duijn, van C.M. (Cock)
    In:Diabetes Care, 2112 - 2113. ISSN 0149-5992.

    Samenvatting:

    Letter

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