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Prof.dr. A. Hofman Person

Prof.dr. A. Hofman

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  • Early cognitive decline is associated with prion protein codon 129 polymorphism (2003)Open access

    Authors:Croes, E.A. (Esther); Dermaut, B. (Bart); Houwing-Duistermaat, J.J. (Jeanine); Broeck, van den M. (Marleen); Cruts, M. (Marc); Breteler, M.M.B. (Monique); Hofman, A. (Albert); Broeckhoven, van C. (Christine); Duijn, van C.M. (Cock)
    In:Annals of Neurology, 54(2), 275 - 276. ISSN 0364-5134.

  • Association of 5' estrogen receptor alpha gene polymorphisms with bone mineral density, vertebral bone area and fracture risk (2003)Open access

    Authors:Meurs, van J.B.J. (Joyce); Uitterlinden, A.G. (André); Pols, H.A.P. (Huibert); Weel, A.E.A.M. (Angelique); Klift, van de M. (Marjolein); Bergink, A.P. (Arjan); Arp, P.P. (Pascal); Fang, Y. (Yue); Duijn, van C.M. (Cock); Leeuwen, van J.P.T.M. (Hans); Schuit, S.C.E. (Stephanie); Hofman, A. (Albert)
    In:Human Molecular Genetics, 12(14), 1745 - 1754. ISSN 0964-6906.

    Abstract:

    This study investigates the influence of genetic variation of the estrogen receptor alpha (ESR1) gene locus on several bone parameters in 2042 individuals of The Rotterdam Study, a prospective population-based cohort study of elderly subjects. We analysed three polymorphic sites in the 5' region of

  • Higher estrogen levels are not associated with larger hippocampi and better memory performance (2003)Open access

    Authors:Heijer, den T. (Tom); Geerlings, M.I. (Miriam); Jong, de F.H. (Frank); Launer, L.J. (Lenore); Pols, H.A.P. (Huibert); Breteler, M.M.B. (Monique); Hofman, A. (Albert)
    In:Archives of Neurology. ISSN 0003-9942.

    Abstract:

    BACKGROUND: Estrogens may prevent cognitive decline and Alzheimer disease. Animal study findings have shown beneficial effects of estrogen on the brain, particularly on the hippocampus, a structure related to memory performance and early Alzheimer disease. OBJECTIVE: To investigate

  • A polymorphism in the IGF-I gene influences the age-related decline in circulating total IGF-I levels (2003)Open access

    Authors:Rietveld, I. (Ingrid); Pols, H.A.P. (Huibert); Duijn, van C.M. (Cock); Lamberts, S.W.J. (Steven); Janssen, J.A.M.J.L. (Joop); Hofman, A. (Albert)
    In:European Journal of Endocrinology, 171 - 175. ISSN 0804-4643.

    Abstract:

    OBJECTIVE: Recent studies have demonstrated an association between a 192 bp polymorphism of the IGF-I gene and total IGF-I serum levels, birth weight, body height and the risk of developing diabetes and cardiovascular diseases later on in life. This IGF-I gene polymorphism in the promoter region of

  • Interaction between vitamin D receptor genotype and estrogen receptor alpha genotype influences vertebral fracture risk (2003)Open access

    Authors:Colin, E.M.; Uitterlinden, A.G. (André); Bergink, A.P. (Arjan); Klift, van de M. (Marjolein); Fang, Y. (Yue); Arp, P.P. (Pascal); Pols, H.A.P. (Huibert); Leeuwen, van J.P.T.M. (Hans); Meurs, van J.B.J. (Joyce); Hofman, A. (Albert)
    In:Journal of Clinical Endocrinology and Metabolism. ISSN 0021-972x.

    Abstract:

    In view of the interactions of vitamin D and the estrogen endocrine system, we studied the combined influence of polymorphisms in the estrogen receptor (ER) alpha gene and the vitamin D receptor (VDR) gene on the susceptibility to osteoporotic vertebral fractures in 634 women aged

  • Association between an insulin-like growth factor I gene promoter polymorphism and bone mineral density in the elderly: the Rotterdam Study (2003)Open access

    Authors:Rivadeneira Ramirez, F. (Fernando); Houwing-Duistermaat, J.J. (Jeanine); Vaessen, N. (Norbert); Vergeer-Drop, J.M.; Pols, H.A.P. (Huibert); Duijn, van C.M. (Cock); Uitterlinden, A.G. (André); Hofman, A. (Albert)
    In:Journal of Clinical Endocrinology and Metabolism. ISSN 0021-972x.

    Abstract:

    Studies of the roles of variants of the IGF-I gene in the regulation of bone mineral density (BMD) have yielded conflicting results. We examined the role of a microsatellite repeat polymorphism in one of the promoter regions of the IGF-I gene in relation to femoral BMD in elderly women and men from

  • Thiazide diuretics and the risk for hip fracture (2003)Open access

    Authors:Klift, van de M. (Marjolein); Laet, de C.E.D. (Chris); Herings, R.M. (Ron); Stijnen, Th. (Theo); Pols, H.A.P. (Huibert); Stricker, B.H.Ch. (Bruno); Schoofs, M.W.C.J. (Marlette); Hofman, A. (Albert)
    In:Annals of Internal Medicine. ISSN 0003-4819.

    Abstract:

    BACKGROUND: Since most hip fractures are related to osteoporosis, treating accelerated bone loss can be an important strategy to prevent hip fractures. Thiazides have been associated with reduced age-related bone loss by decreasing urinary calcium excretion. OBJECTIVE: To examine the association bet

  • Cholesterol lowering drugs and risk of age related maculopathy: prospective cohort study with cumulative exposure measurement (2003)Open access

    Authors:Leeuwen, van R. (Redmer); Vingerling, J.R. (Hans); Jong, de P.T.V.M. (Paulus); Stricker, B.H.Ch. (Bruno); Hofman, A. (Albert)
    In:BMJ British medical journal. ISSN 1468-5833.

  • Homocysteine and brain atrophy on MRI of non-demented elderly (2003)Open access

    Authors:Heijer, den T. (Tom); Vermeer, S.E. (Sarah); Clarke, R.; Oudkerk, M. (Matthijs); Koudstaal, P.J. (Peter); Breteler, M.M.B. (Monique); Hofman, A. (Albert)
    In:Brain: a journal of neurology. ISSN 0006-8950.

    Abstract:

    Patients with Alzheimer's disease have higher plasma homocysteine levels than controls, but it is uncertain whether higher plasma homocysteine levels are involved in the early pathogenesis of the disease. Hippocampal, amygdalar and global brain atrophy on brain MRI have been propos

  • Blood pressure, atherosclerosis, and the incidence of age-related maculopathy: the Rotterdam Study (2003)Open access

    Authors:Leeuwen, van R. (Redmer); Ikram, M.K. (Kamran); Vingerling, J.R. (Hans); Witteman, J.C.M. (Jacqueline); Jong, de P.T.V.M. (Paulus); Hofman, A. (Albert)
    In:Investigative Ophthalmology & Visual Science. ISSN 0146-0404.

    Abstract:

    PURPOSE: To determine whether blood pressure and subclinical atherosclerosis are associated with incident age-related maculopathy (ARM). METHODS: The study was performed within the Rotterdam Study, a population-based, prospective cohort study in Rotterdam, The Netherlands. A

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