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Prof.dr. H.A. Verbrugh

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  • Correlation of bacterial colonization status between mother and child: The generation R study (2010)

    Auteurs:Lebon, A. (Ankie); Moll, H.A. (Henriëtte); Tavakol, M. (Mehri); Wamel, van W.J.B. (Willem); Jaddoe, V.W.V. (Vincent); Hofman, A. (Albert); Verbrugh, H.A. (Henri); Belkum, van A.F. (Alex)
    In:Journal of Clinical Microbiology, 48(3), 960 - 962. ISSN 0095-1137.

    Samenvatting:

    Determinants of bacterial colonization in children have been described. In the Generation R Study, a population-based cohort study, we determined whether the colonization statuses of mothers and children are correlated. Such a correlation was observed for Staphylococcus aureus and Haemophilus influe

  • Preventing Surgical-Site Infections in Nasal Carriers of Staphylococcus aureus (2010)

    Auteurs:Bode, L.G.M. (Lonneke); Kluytmans, J.A.J.W.; Wertheim, H.F.L. (Heiman); Bogaers, D. (Diana); Vandenbroucke-Grauls, C.M.J.E. (Christina); Roosendaal, R. (Robert); Troelstra, A. (Annet); Box, A.T.A. (Adrienne); Voss, A. (Andreas); Tweel, van der I. (Ingeborg); Belkum, van A.F. (Alex); Verbrugh, H.A. (Henri); Vos, M.C. (Margreet)
    In:New England Journal of Medicine, 362(1), 9 - 17. ISSN 0028-4793.

    Samenvatting:

    Background Nasal carriers of Staphylococcus aureus are at increased risk for health care–associated infections with this organism. Decolonization of nasal and extranasal sites on hospital admission may reduce this risk. Methods In a randomized, double-blind, placebo-controlled, multicenter trial, w

  • Molecular characterization of extended-spectrum β-lactamases in clinical Escherichia coli and Klebsiella pneumoniae isolates from Surabaya, Indonesia (2010)

    Auteurs:Severin, J.A. (Juliëtte); Mertaniasih, N.M.; Kuntaman, K. (Kuntaman); Lestari, E.S. (Endang Sri); Purwanta, M. (Marijam); Lemmens-den Toom, N.; Duerink, D.O. (Offra); Hadi, U. (Usman); Belkum, van A.F. (Alex); Verbrugh, H.A. (Henri); Goessens, W.H.F. (Wil)
    In:Journal of Antimicrobial Chemotherapy, 65(3), 465 - 469. ISSN 0305-7453.

    Samenvatting:

    Background: No detailed reports regarding extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae are currently available from Indonesia, the fourth most populous country in the world. Methods: A survey was carried out to investigate the molecular epidemiology and genetic characteristics o

  • Short term micro-evolution and PCR-detection of methicillin-resistant and -susceptible Staphylococcus aureus sequence type 398 (2010)Open access

    Auteurs:Wamel, van W.J.B. (Willem); Hansenová Maňásková, S.; Fluit, A.; Verbrugh, H.A. (Henri); Neeling, de A.J. (Albert); Duijkeren, van E. (Engeline); Belkum, van A.F. (Alex)
    In:European Journal of Clinical Microbiology & Infectious Diseases: an international journal on pathogenesis, diagnosis, epidemiology, therapy, and prevention of infectious diseases, 29(1), 119 - 122. ISSN 0934-9723.

    Samenvatting:

    Micro-evolutionary analysis of 70 ST398 isolates by pulsed-field gel electrophoresis (PFGE) using Cfr9I revealed three sub-clones with abundant inter- and intra-sub-clone heterogeneity in spa- and SCC mec-types. In addition, we developed two specific PCRs for the detection of Staphylococcus aureus s

  • Immunogenicity of toxins during Staphylococcus aureus infection (2010)Open access

    Auteurs:Verkaik, N.J. (Nelianne); Dauwalder, O. (Olivier); Antri, K. (Kenza); Boubekri, I. (Ilhem); Vogel, de C.P. (Corné); Badiou, C. (Cédric); Bes, M. (Michèle); Vandenesch, F. (François); Tazir, M. (Mohammed); Hooijkaas, H. (Herbert); Verbrugh, H.A. (Henri); Belkum, van A.F. (Alex); Etienne, J. (Jerome); Lina, G. (Gerard); Ramdani-Bouguessa, N. (Nadjia); Wamel, van W.J.B. (Willem)
    In:Clinical Infectious Diseases, 50(1), 61 - 68. ISSN 1058-4838.

    Samenvatting:

    AB - BACKGROUND: Toxins are important Staphylococcus aureus virulence factors, but little is known about their immunogenicity during infection. Here, additional insight is generated. METHODS: Serum samples from 206 S. aureus-infected patients and 201 hospital-admitted control subjects were analyzed

  • Transmission of methicillin-resistant Staphylococcus aureus to household contacts (2010)

    Auteurs:Mollema, F.P.N. (Femke); Richardus, J.H. (Jan Hendrik); Behrendt, M.D. (Myra); Vaessen, N. (Norbert); Lodder, W.; Hendriks, W.; Verbrugh, H.A. (Henri); Voss, A. (Andreas)
    In:Journal of Clinical Microbiology, 48(1), 202 - 207. ISSN 0095-1137.

    Samenvatting:

    The frequency of and risk factors for methicillin-resistant Staphylococcus aureus (MRSA) transmission from a MRSA index person to household contacts were assessed in this prospective study. Between January 2005 and December 2007, 62 newly diagnosed MRSA index persons (46 patients and 16 health care

  • 5 years of experience implementing a methicillin-resistant Staphylococcus aureus search and destroy policy at the largest university medical center in the Netherlands (2009)Open access

    Auteurs:Vos, M.C. (Margreet); Behrendt, M.D. (Myra); Melles, D.C. (Damian); Mollema, F.P.N. (Femke); Groot, de W. (Woutrinus); Parlevliet, G. (Gerard); Ott, A. (Alewijn); Horst-Kreft, D. (Deborah); Belkum, van A.F. (Alex); Verbrugh, H.A. (Henri)
    In:Infection Control & Hospital Epidemiology, 30(10), 977 - 984. ISSN 0899-823x.

    Samenvatting:

    OBJECTIVE: To evaluate the effectiveness of a rigorous search and destroy policy for controlling methicillin-resistant Staphylococcus aureus (MRSA) infection or colonization. DESIGN: Hospital-based observational follow-up study. SETTING: Erasmus University Medical Center Rotterdam, a 1,200-bed terti

  • Anti-staphylococcal humoral immune response in persistent nasal carriers and noncarriers of Staphylococcus aureus (2009)Open access

    Auteurs:Verkaik, N.J. (Nelianne); Vogel, de C.P. (Corné); Boelens, H.A.M. (Hélène); Grumann, D. (Dorothee); Hoogenboezem, T. (Theo); Vink, C. (Cornelis); Hooijkaas, H. (Herbert); Foster, T.J. (Timothy); Verbrugh, H.A. (Henri); Belkum, van A.F. (Alex); Wamel, van W.J.B. (Willem)
    In:The Journal of Infectious Diseases, 199(5), 625 - 632. ISSN 0022-1899.

    Samenvatting:

    BACKGROUND. Persistent carriers have a higher risk of Staphylococcus aureus infections than noncarriers but a lower risk of bacteremia-related death. Here, the role played by anti-staphylococcal antibodies was studied. METHODS. Serum samples from 15 persistent carriers and 19 noncarriers were analyz

  • Host polymorphisms in interleukin 4, complement factor H, and C-reactive protein associated with nasal carriage of Staphylococcus aureus and occurrence of boils (2008)

    Auteurs:Emonts, M. (Marieke); Uitterlinden, A.G. (André); Nouwen, J.L. (Jan); Kardys, I. (Isabella); Maat, de M.P.M. (Moniek); Melles, D.C. (Damian); Witteman, J.C.M. (Jacqueline); Jong, de P.T.V.M. (Paulus); Verbrugh, H.A. (Henri); Hofman, A. (Albert); Hermans, P.W.M. (Peter); Belkum, van A.F. (Alex)
    In:The Journal of Infectious Diseases, 197(9), 1244 - 1253. ISSN 0022-1899.

    Samenvatting:

    Background. Staphylococcus aureus is capable of persistently colonizing the vestibulum nasi. We hypothesized that polymorphisms in host inflammatory response genes and genetic variation in S. aureus contribute to susceptibility to S. aureus carriage and infection. Methods. The prevalence of persiste

  • Rapid identification of mycobacteria by Raman spectroscopy (2008)

    Auteurs:Buijtels, P.C.A.M. (Petronella Catharina Adriana Maria); Willemse-Erix, H.F.M.; Petit, P.L. (Pieter); Endtz, H.P. (Hubert); Puppels, G.J. (Gerwin); Verbrugh, H.A. (Henri); Belkum, van A.F. (Alex); Soolingen, van D. (Dick); Maquelin, K. (Kees)
    In:Journal of Clinical Microbiology, 46(3), 961 - 965. ISSN 0095-1137.

    Samenvatting:

    A number of rapid identification methods have been developed to improve the accuracy for diagnosis of tuberculosis and to speed up the presumptive identification of Mycobacterium species. Most of these methods have been validated for a limited group of microorganisms only. Here, Raman spectroscopy w

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