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Prof.dr. A. Hofman Persoon

Prof.dr. A. Hofman

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  • Common genetic determinants of vitamin D insufficiency: A genome-wide association study (2010)

    Auteurs:Wang, T.J. (Thomas); Zhang, F. (Feng); Richards, J.B. (Brent); Kestenbaum, B. (Bryan); Meurs, van J.B.J. (Joyce); Berry, D. (Diane); Kiel, D.P. (Douglas); Streeten, E.A. (Elizabeth); Ohlsson, C. (Claes); Koller, D.L. (Daniel); Peltonen, L. (Leena Johanna); Cooper, C. (Charles); O'Reilly, P.F. (Paul); Houston, D.K. (Denise); Glazer, N.L. (Nicole); Vandenput, L. (Liesbeth); Peacock, M. (Munro); Shi, J. (Julia); Rivadeneira Ramirez, F. (Fernando); McCarthy, M.I. (Mark); Anneli, P. (Pouta); Boer, de I.H. (Ian); Mangino, M. (Massimo); Kato, B. (Bernet); Smyth, D.J. (Deborah); Booth, S.L. (Sarah); Jacques, P.F. (Paul); Burke, G.L. (Greg); Goodarzi, M. (Mark); Cheung, C.L.; Wolf, M. (Myles); Rice, K. (Kenneth); Goltzman, D. (David); Hidiroglou, N. (Nick); Ladouceur, M. (Martin); Wareham, N.J. (Nicholas); Hocking, L.J. (Lynne); Hart, D.J. (Deborah); Arden, N.K. (Nigel); Malik, S. (Suneil); Fraser, W.D. (William); Hartikainen, A.L.; Zhai, G. (Guangju); Macdonald, H.M. (Helen); Forouhi, N.G. (Nita); Loos, R.J.F. (Ruth); Reid, D.M. (David); Hakim, A. (Abdul); Dennison, E.M. (Elaine); Liu, Y. (Yongmei); Power, C. (Christopher); Stevens, H.E. (Helen); Jaana, L. (Laitinen); Vasan, R.S. (Ramachandran Srini); Soranzo, N. (Nicole); Bojunga, J. (Jörg); Psaty, B.M. (Bruce); Lorentzon, M. (Mattias); Foroud, T. (Tatiana); Harris, T.B. (Tamara); Hofman, A. (Albert); Jansson, J.O.; Cauley, J.A. (Jane); Uitterlinden, A.G. (André); Gibson, Q. (Quince); Jarvelin, M.R.; Karasik, D. (David); Siscovick, D.S. (David); Econs, M.J. (Michael); Kritchevsky, S.B. (Stephen); Florez, J.C. (Jose); Todd, J.A. (John); Dupuis, J. (Josée); Hyppönen, E. (Elina); Spector, T.D. (Timothy)
    In:The Lancet, 376(9736), 180 - 188. ISSN 0140-6736.

    Samenvatting:

    Background Vitamin D is crucial for maintenance of musculoskeletal health, and might also have a role in extraskeletal tissues. Determinants of circulating 25-hydroxyvitamin D concentrations include sun exposure and diet, but high heritability suggests that genetic factors could also play a part. We

  • Explaining Ethnic Differences in Late Antenatal Care Entry by Predisposing, Enabling and Need Factors in the Netherlands. The Generation R Study (2010)Open access

    Auteurs:Choté, A.A. (Anushka); Koopmans, G. (Gerrit); Orlewska, E. (William Ken); Groot, de C.J.M. (Christianne); Hoefman, R.J.; Jaddoe, V.W.V. (Vincent); Hofman, A. (Albert); Steegers, E.A.P. (Eric); Mackenbach, J.P. (Johan); Trappenburg, M.J. (Margo); Foets, M.M.E. (Marleen)
    In:Maternal and Child Health Journal, 15, 689 - 699. ISSN 1092-7875.

    Samenvatting:

    Despite compulsory health insurance in Europe, ethnic differences in access to health care exist. The objective of this study is to investigate how ethnic differences between Dutch and non-Dutch women with respect to late entry into antenatal care provided by community midwifes can be explained by n

  • Genetic risk profiles for depression and anxiety in adult and elderly cohorts (2010)Open access

    Auteurs:Demirkan, A. (Ayşe); Penninx, B.W.J.H. (Brenda); Hek, K. (Karin); Wray, N.R. (Naomi); Amin, N. (Najaf); Aulchenko, Y.S. (Yurii); Dyck, van R. (Richard); Geus, de E.J.C. (Eco); Hofman, A. (Albert); Uitterlinden, A.G. (André); Hottenga, J.J.; Nolen, W.A. (Willem); Oostra, B.A. (Ben); Sullivan, P.F. (Patrick); Willemsen, G.A.H.M. (Gonneke); Zitman, F.G. (Frans); Tiemeier, H. (Henning); Janssens, A.C.J.W. (Cécile); Boomsma, D.I. (Dorret); Duijn, van C.M. (Cock); Middeldorp, C.M. (Christel)
    In:Molecular Psychiatry, 16(7), 773 - 783. ISSN 1359-4184.

    Samenvatting:

    Abstract The first generation of genome-wide association studies (GWA studies) for psychiatric disorders has led to new insights regarding the genetic architecture of these disorders. We now start to realize that a larger number of genes, each with a small contribution, are likely to explain the he

  • A genome-wide association study of optic disc parameters (2010)Open access

    Auteurs:Ramdas, W.D. (Wishal); Koolwijk, van L.M.E. (Leonieke); Ikram, M.K. (Kamran); Jansonius, N.M. (Nomdo); Jong, de P.T.V.M. (Paulus); Bergen, A.A.B. (Arthur); Isaacs, A.J. (Aaron); Amin, N. (Najaf); Aulchenko, Y.S. (Yurii); Wolfs, R.C.W. (Roger); Hofman, A. (Albert); Rivadeneira Ramirez, F. (Fernando); Oostra, B.A. (Ben); Uitterlinden, A.G. (André); Hysi, P.G. (Pirro); Hammond, C.J. (Christopher); Lemij, H.G. (Hans); Vingerling, J.R. (Hans); Klaver, C.C.W. (Caroline); Duijn, van C.M. (Cock)
    In:P L o S Genetics (Print), 6(6), 1 - 12. ISSN 1553-7390.

    Samenvatting:

    The optic nerve head is involved in many ophthalmic disorders, including common diseases such as myopia and open-angle glaucoma. Two of the most important parameters are the size of the optic disc area and the vertical cup-disc ratio (VCDR). Both are highly heritable but genetically largely undeterm

  • Maternal caffeine intake from coffee and tea, fetal growth, and the risks of adverse birth outcomes: The Generation R Study (2010)

    Auteurs:Bakker, R. (Rachel); Steegers-Theunissen, R.P.M. (Regine); Obradov, A. (Aleksandra); Raat, H. (Hein); Hofman, A. (Albert); Jaddoe, V.W.V. (Vincent)
    In:The American Journal of Clinical Nutrition, 91(6), 1691 - 1698. ISSN 0002-9165.

    Samenvatting:

    Background: Caffeine is a widely used and accepted pharmacologically active substance. The effect of caffeine intake during pregnancy on fetal growth and development is still unclear. Objective: We examined the associations of maternal caffeine intake, on the basis of coffee and tea consumption, wit

  • Genomic variation associated with mortality among adults of European and African ancestry with heart failure: The cohorts for heart and aging research in genomic epidemiology consortium (2010)

    Auteurs:Morrison, A.C. (Alanna); Felix, J.F. (Janine); Cupples, L.A. (Adrienne); Glazer, N.L. (Nicole); Loehr, L.R. (Laura); Dehghan, A. (Abbas); Demissie, S. (Serkalem); Bis, J.C. (Joshua); Rosamond, W.D. (Wayne); Aulchenko, Y.S. (Yurii); Wang, T.J. (Thomas); Haritunians, T. (Talin); Folsom, A.R. (Aaron); Rivadeneira Ramirez, F. (Fernando); Benjamin, E.J. (Emelia); Lumley, T. (Thomas); Couper, D.J. (David); Stricker, B.H.Ch. (Bruno); Rice, K. (Kenneth); Chang, P.P. (Patricia); Hofman, A. (Albert); Levy, D. (Daniel); Rotter, J.I. (Jerome); Fox, E.R. (Ervin); Uitterlinden, A.G. (André); Psaty, B.M. (Bruce); Willerson, J.T. (James); Tikka-Kleemola, P. (Päivi); Boerwinkle, E. (Eric); Witteman, J.C.M. (Jacqueline); Vasan, R.S. (Ramachandran Srini); Smith, N.L. (Nicholas); O'Donnell, C.J. (Christopher)
    In:Circulation: Cardiovascular Genetics, 3(3), 248 - 255. ISSN 1942-325x.

    Samenvatting:

    Background-Prognosis and survival are significant concerns for individuals with heart failure (HF). To better understand the pathophysiology of HF prognosis, the association between 2 366 858 single-nucleotide polymorphisms (SNPs) and all-cause mortality was evaluated among individuals with incident

  • Lipoprotein-associated phospholipase A2 and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies (2010)

    Auteurs:Thompson, A. (Alexander); Gao, P. (Pei); Orfei, L. (Lia); Watson, S. (Sarah); Angelantonio, di E. (Emanuele); Kaptoge, S. (Stephen); Ballantyne, C. (Christie); Cannon, C.P.; Criqui, M. (Michael); Cushman, M. (Mary Ann); Hofman, A. (Albert); Packard, C. (Chris); Collins, R. (Rory); Danesh, J. (John)
    In:The Lancet, 375(9725), 1536 - 1544. ISSN 0140-6736.

    Samenvatting:

    Background: Lipoprotein-associated phospholipase A2(Lp-PLA2), an inflammatory enzyme expressed in atherosclerotic plaques, is a therapeutic target being assessed in trials of vascular disease prevention. We investigated associations of circulating Lp-PLA2mass and activity with risk of coronary heart

  • A Meta-analysis of four genome-wide association studies of survival to age 90 years or older: The cohorts for heart and aging research in genomic epidemiology consortium (2010)

    Auteurs:Newman, A.B. (Anne); Walter, S. (Stefan); Lunetta, K.L. (Kathryn); Garcia, M. (Melissa); Slagboom, P.E. (Eline); Christensen, K. (Kaare); Arnold, A.M. (Alice); Aspelund, T. (Thor); Aulchenko, Y.S. (Yurii); Benjamin, E.J. (Emelia); Christiansen, L. (Lene); D'Agostino, R.B. (Ralph); Fitzpatrick, A.L. (Annette); Franceschini, N. (Nora); Glazer, N.L. (Nicole); Gudnason, V. (Vilmundur); Hofman, A. (Albert); Kaplan, R.; Karasik, D. (David); Kelly-Hayes, M. (Margaret); Kiel, D.P. (Douglas); Launer, L.J. (Lenore); Marciante, K. (Kristin); Massaro, J. (Joseph); Miljkovic, I. (Iva); Nalls, M.A. (Michael); Hernandez, D.G. (Dena); Psaty, B.M. (Bruce); Rivadeneira Ramirez, F. (Fernando); Rotter, J.I. (Jerome); Seshadri, S. (Sudha); Smith, A.V. (Albert Vernon); Taylor, K.D. (Kent); Tiemeier, H. (Henning); Uh, H.W.; Uitterlinden, A.G. (André); Vaupel, J.W. (James); Walston, J. (Jeremy); Westendorp, R.G.J. (Rudi); Harris, T.B. (Tamara); Lumley, T. (Thomas); Tikka-Kleemola, P. (Päivi); Murabito, J. (Joanne)
    In:Journals of Gerontology. Series A: Biological Sciences & Medical Sciences, 65 A(5), 478 - 487. ISSN 1079-5006.

    Samenvatting:

    Background.Genome-wide association studies (GWAS) may yield insights into longevity.Methods.We performed a meta-analysis of GWAS in Caucasians from four prospective cohort studies: the Age, Gene/Environment Susceptibility-Reykjavik Study, the Cardiovascular Health Study, the Framingham Heart Study,

  • Interactions between dietary vitamin E intake and SIRT1 genetic variation influence body mass index (2010)

    Auteurs:Zillikens, M.C. (Carola); Meurs, van J.B.J. (Joyce); Rivadeneira Ramirez, F. (Fernando); Hofman, A. (Albert); Oostra, B.A. (Ben); Sijbrands, E.J.G. (Eric); Witteman, J.C.M. (Jacqueline); Pols, H.A.P. (Huibert); Tikka-Kleemola, P. (Päivi); Uitterlinden, A.G. (André)
    In:The American Journal of Clinical Nutrition, 91(5), 1387 - 1393. ISSN 0002-9165.

    Samenvatting:

    Background: Genetic variation in SIRT1 has been associated with body mass index (BMI) and risk of obesity. SIRT1 may be influenced by diet. Objective: We studied the gene-diet interaction on BMI at the SIRT1 locus. Design: In 4575 elderly men and women in the population-based Rotterdam Study, the ef

  • Intake of fish and marine n-3 fatty acids in relation to coronary calcification: The Rotterdam Study (2010)

    Auteurs:Heine-Bröring, R.C. (Renate); Brouwer, I.A. (Ingeborg); Proença, R.V.; Rooij, van F.J.A. (Frank); Hofman, A. (Albert); Oudkerk, M. (Matthijs); Witteman, J.C.M. (Jacqueline); Geleijnse, J.M. (Marianne)
    In:The American Journal of Clinical Nutrition, 91(5), 1317 - 1323. ISSN 0002-9165.

    Samenvatting:

    Background: Epidemiologic and experimental data suggest a cardioprotective effect of n23 (omega-3) fatty acids from fish [eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA)]. Objective: The objective was to examine the association of fish and EPA plus DHA intakes with coronary calcification

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