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Prof.dr. A. Hofman Person

Prof.dr. A. Hofman

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  • Renal function is related to severity of coronary artery calcification in elderly persons: The Rotterdam study (2011)

    Authors:El Barzouhi, A. (Abdelilah); Elias-Smale, S.E. (Suzette); Dehghan, A. (Abbas); Vliegenthart, R. (Rozemarijn); Oudkerk, M. (Matthijs); Hofman, A. (Albert); Witteman, J.C.M. (Jacqueline)
    In:PLoS ONE, 6(2). ISSN 1932-6203.

    Abstract:

    Background: Coronary artery calcification (CAC) has been proposed to be the underlying mechanism of the increased risk of coronary heart disease with reductions in glomerular filtration rate (GFR). Since renal function diminishes with aging we examined the association between GFR and CAC in the Rott

  • Individual accumulation of heterogeneous risks explains perinatal inequalities within deprived neighbourhoods (2011)

    Authors:Timmermans, S. (Sarah); Bonsel, G.J. (Gouke); Steegers-Theunissen, R.P.M. (Regine); Mackenbach, J.P. (Johan); Steyerberg, E.W. (Ewout); Raat, H. (Hein); Verbrugh, H.A. (Henri); Tiemeier, H. (Henning); Hofman, A. (Albert); Birnie, E. (Erwin); Looman, C.W.N. (Caspar); Jaddoe, V.W.V. (Vincent)
    In:European Journal of Epidemiology, 26(2), 165 - 180. ISSN 0393-2990.

    Abstract:

    Dutch' figures on perinatal mortality and morbidity are poor compared to EU-standards. Considerable within-country differences have been reported too, with decreased perinatal health in deprived urban areas. We investigated associations between perinatal risk factors and adverse perinatal outcomes i

  • OCT1 polymorphism is associated with response and survival time in anti-Parkinsonian drug users (2011)Open access

    Authors:Becker, M.L. (Matthijs); Visser, L.E. (Loes); Schaik, van R.H.N. (Ron); Hofman, A. (Albert); Uitterlinden, A.G. (André); Stricker, B.H.Ch. (Bruno)
    In:Neurogenetics, 12(1), 79 - 82. ISSN 1364-6745.

    Abstract:

    Substrates for the Organic Cation Transporter 1, encoded by the SLC22A1 gene, are metformin, amantadine, pramipexole, and, possibly, levodopa. Recently, we identified that the rs622342 A > C polymorphism is associated with the HbA1c lowering effect in metformin users. In the Rotterdam Study, we asso

  • Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease (2011)Open access

    Authors:Schunkert, H.; König, I.R.; Kathiresan, S.; Reilly, M.P.; Assimes, T.L.; Holm, H.; Preuss, M.; Stewart, A.F.R.; Barbalic, M.; Gieger, C.; Absher, D.; Aherrahrou, Z.; Allayee, H.; Altshuler, D.; Anand, S.S.; Andersen, K.; Anderson, J.L.; Ardissino, D.; Ball, S.G.; Balmforth, A.J.; Barnes, T.A.; Becker, D.M.; Berger, K.; Bis, J.C.; Boekholdt, S.M.; Boerwinkle, E.; Braund, P.S.; Brown, M.J.; Burnett, M.S.; Buysschaert, I.; Carlquist, J.F.; Chen, L.; Cichon, S.; Codd, V.; Davies, R.W.; Dedoussis, G.V.; Dehghan, A.; Demissie, S; Devaney, J.; Diemert, P.; Do, R.; Doering, A.; Eifert, S.; Mokhtari, N.E.E.; Ellis, S.G.; Elosua, R.; Engert, J.C.; Epstein, S.E.; Faire, U. de; Fischer, M.; Folsom, A.R.; Freyer, J.; Gigante, B.; Girelli, D.; Gretarsdottir, S.; Gudnason, V.; Gulcher, J.R.; Halperin, E.; Hammond, N.; Hazen, S.L.; Hofman, A.; Horne, B.D.; Illig, T.; Iribarren, C.; Jones, G.T.; Jukema, J.W.; Kaiser, M.A.; Kaplan, R.; Khaw, K-T.; Knowles, J.W.; Kolovou, G.; Kong, A.; Laaksonen, R.; Lambrechts, D.; Leander, K.; Lettre, G.; Li, X.; Lieb, W.; Loley, C.; Lotery, A.J.; Mannucci, P.M.; Maouche, S.; Martinelli, N.; McKeown, P.P.; Meisinger, C.; Meitinger, T.; Melander, O.; Merlini, P.A.; Mooser, V.; Morgan, T.; Mühleisen, T.W.; Muhlestein, J.B.; Münzel, T.; Musunuru, K.; Nahrstaedt, J.; Nelson, C.P.; Nöthen, M.M.; Olivieri, O.; Patel, R.S.; Patterson, C.C.; Peters, A.; Peyvandi, F.; Qu, L.; Quyyumi, A.A.; Rader, D.J.; Rallidis, L.S.; Rice, C.; Rosendaal, F.R.; Rubin, D.; Salomaa, V.; Sampietro, M.L.; Sandhu, M.S.; Schadt, E.E.; Scḧsignfer, A.; Schillert, A.; Schreiber, S.; Schrezenmeir, J.; Schwartz, S.M.; Siscovick, D.S.; Sivananthan, M.; Sivapalaratnam, S.; Smith, A.V.; Snoep, J.D.; Soranzo, N.; Spertus, J.A.; Stark, K.; Stirrups, K.; Stoll, M.; Tang, W.H.W.; Tennstedt, S.; Thorgeirsson, G.; Thorleifsson, G.; Tomaszewski, M.; Uitterlinden, A.G.; Rij, A.M. van; Voight, B.F.; Wareham, N.J.; Wells, G.; Wichmann, H.E.; Wild, P.S.; Willenborg, C.; Witteman, J.C.M.; Wright, B.J.; Ye, S.; Zeller, T.; Ziegler, A.; Cambien, F.; Goodall, A.H.; Cupples, L.A.; Quertermous, T.; Mäsignrz, W.; Hengstenberg, C.; Blankenberg, S.; Ouwehand, W.H.; Hall, A.S.; Kastelein, J.J.P.; Deloukas, P.; Thompson, J.R.; Stefansson, K.; Roberts, R.; Thorsteinsdottir, U.; O'Donnell, C.J.; McPherson, R.; Erdmann, J.; Samani, N.J.; Erasmus MC: University Medical Center Rotterdam
    In:Nature Genetics, 43(4), 333 - 340. ISSN 1061-4036.

    Abstract:

    We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 l

  • Risk factors for otitis media in children with special emphasis on the role of colonization with bacterial airway pathogens: The Generation R study (2011)Open access

    Authors:Labout, J.A.M.; Dujits, L.; Lebon, A.; Groot, R. de; Hofman, A.; Jaddoe, V.W.V.; Verbrugh, H.A.; Hermans, P.W.M.; Moll, H.A.
    In:European Journal of Epidemiology, 26(1), 61 - 66. ISSN 0393-2990.

    Abstract:

    Acute otitis media is the most frequent diagnosis in children visiting physicians' offices. Risk factors for otitis media have been widely studied. Yet, the correlation between bacterial carriage and the development of otitis media is not entirely clear. Our aim was to study in a population-based pr

  • Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors (2010)

    Authors:Yang, Q. (Qiong Fang); Köttgen, A. (Anna); Dehghan, A. (Abbas); Smith, A.V. (Albert Vernon); Glazer, N.L. (Nicole); Chen, M-H. (Ming-Huei); Chasman, D.I. (Daniel); Aspelund, T. (Thor); Eiriksdottir, G. (Gudny); Harris, T.B. (Tamara); Launer, L.J. (Lenore); Nalls, M.A. (Michael); Hernandez, D.G. (Dena); Arking, D.E. (Dan); Boerwinkle, E. (Eric); Grove, M.L. (Megan); Li, M. (Man); Linda Kao, W.H.; Chonchol, M. (Michel); Haritunians, T. (Talin); Lumley, T. (Thomas); Psaty, B.M. (Bruce); Shlipak, M.G. (Michael); Hwang, S.J.; Larson, M.G. (Martin); O'Donnell, C.J. (Christopher); Upadhyay, A. (Ashish); Tikka-Kleemola, P. (Päivi); Hofman, A. (Albert); Rivadeneira Ramirez, F. (Fernando); Stricker, B.H.Ch. (Bruno); Uitterlinden, A.G. (André); Paré, G. (Guillaume); Parker, A.N. (Alex); Ridker, P.M. (Paul); Siscovick, D.S. (David); Gudnason, V. (Vilmundur); Witteman, J.C.M. (Jacqueline); Fox, C.S. (Caroline); Coresh, J. (Josef)
    In:Circulation: Cardiovascular Genetics, 3(6), 523 - 530. ISSN 1942-325x.

    Abstract:

    Background - Elevated serum urate levels can lead to gout and are associated with cardiovascular risk factors. We performed a genome-wide association study to search for genetic susceptibility loci for serum urate and gout and investigated the causal nature of the associations of serum urate with go

  • Editorial: New studies, technology, and the progress of epidemiology (2010)Open access

    Author:Hofman, A. (Albert)
    In:European Journal of Epidemiology, 25(12), 851 - 854. ISSN 0393-2990.

  • Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies (2010)

    Authors:Elks, C.E. (Cathy); Perry, J.R.B. (John); Sulem, P. (Patrick); Chasman, D.I. (Daniel); Franceschini, N. (Nora); He, C. (Chunyan); Lunetta, K.L. (Kathryn); Visser, J.A. (Jenny); Byrne, E.M. (Enda); Cousminer, D.L. (Diana); Gudbjartsson, D.F. (Daniel); Esko, T. (Tõnu); Feenstra, B. (Bjarke); Hottenga, J.J.; Koller, D.L. (Daniel); Kutalik, Z. (Zoltán); Lin, P. (Peng); Mangino, M. (Massimo); Marongiu, M. (Mara); McArdle, P.F. (Patrick); Smith, A.V. (Albert Vernon); Stolk, L. (Lisette); Wingerden, van S. (Sophie); Zhao, J.H.; Albrecht, E. (Eva); Corre, T. (Tanguy); Ingelsson, E. (Erik); Hayward, C. (Caroline); Magnusson, P.K. (Patrik); Ulivi, S. (Shelia); Warrington, N.; Zgaga, L. (Lina); Alavere, H. (Helene); Amin, N. (Najaf); Aspelund, T. (Thor); Bandinelli, S. (Stefania); Barroso, I. (Inês); Berenson, G. (Gerald); Bergmann, S. (Sven); Blackburn, H. (Hannah); Boerwinkle, E. (Eric); Buring, J.E. (Julie); Busonero, F.; Campbell, H. (Harry); Chanock, S.J. (Stephen); Chen, W.; Cornelis, M. (Marilyn); Couper, D.J. (David); Coviello, A.D. (Andrea); D'Adamo, P. (Pio); Faire, de U. (Ulf); Geus, de E.J.C. (Eco); Deloukas, P. (Panagiotis); Döring, A. (Angela); Easton, D.F. (Douglas); Eiriksdottir, G. (Gudny); Emilsson, V. (Valur); Eriksson, J.G. (Johan); Ferrucci, L. (Luigi); Folsom, A.R. (Aaron); Foroud, T. (Tatiana); Garcia, M. (Melissa); Gasparini, P. (Paolo); Geller, F. (Frank); Gieger, C. (Christian); Gudnason, V. (Vilmundur); Hall, A.S. (Alistair); Hankinson, S.E. (Susan); Ferreli, L. (Liana); Heath, A.C. (Andrew); Hernandez, D.G. (Dena); Hofman, A. (Albert); Hu, F.B. (Frank); Illig, T. (Thomas); Järvelin, M.R.; Johnson, A.D. (Andrew); Karasik, D. (David); Khaw, K-T. (Kay-Tee); Kiel, D.P. (Douglas); Kilpelänen, T.O. (Tuomas); Kolcic, I. (Ivana); Kraft, P. (Peter); Launer, L.J. (Lenore); Laven, J.S.E. (Joop); Li, S. (Shengxu); Liu, J. (Jianjun); Levy, D. (Daniel); Martin, N.G. (Nicholas); Melbye, M. (Mads); Mooser, V. (Vincent); Murray, J.C. (Jeffrey); Nalls, M.A. (Michael); Navarro, P. (Pau); Nelis, M. (Mari); Ness, A.R. (Andrew); Northstone, K. (Kate); Oostra, B.A. (Ben); Peacock, M. (Munro); Palmer, C. (Cameron); Palotie, A. (Aarno); Paré, G. (Guillaume); Parker, A.N. (Alex); Pedersen, N.L. (Nancy); Peltonen, L. (Leena Johanna); Pennell, C.E. (Craig); Pharoah, P. (Paul); Polasek, O. (Ozren); Plump, A.S. (Andrew); Pouta, A. (Anneli); Porcu, E. (Eleonora); Rafnar, T. (Thorunn); Rice, J.P. (John); Ring, S.M. (Susan); Rivadeneira Ramirez, F. (Fernando); Rudan, I. (Igor); Sala, C. (Cinzia); Salomaa, V. (Veikko); Sanna, S.; Schlessinger, D.; Schork, N.J. (Nicholas); Scuteri, A. (Angelo); Segrè, A.V. (Ayellet); Shuldiner, A.R. (Alan); Soranzo, N. (Nicole); Sovio, U. (Ulla); Srinivasan, S.R. (Sathanur); Strachan, D.P. (David); Tammesoo, M.L.; Tikkanen, E. (Emmi); Toniolo, D. (Daniela); Tsui, K. (Kim); Tryggvadottir, L. (Laufey); Tyrer, J.P. (Jonathan); Uda, M.; Dam, van R.M. (Rob); Meurs, van J.B.J. (Joyce); Vollenweider, P. (Peter); Waeber, G. (Gérard); Wareham, N.J. (Nicholas); Waterworth, D. (Dawn); Weedon, M.N. (Michael); Wichmann, H.E. (Heinz Erich); Willemsen, G.A.H.M. (Gonneke); Wilson, J.F. (James); Wright, A.F. (Alan); Young, L. (Lauren); Zhai, G. (Guangju); Zhuang, W.V.; Bierut, L.J. (Laura); Boomsma, D.I. (Dorret); Boyd, H.A. (Heather); Crisponi, L. (Laura); Demerath, E.W. (Ellen); Tikka-Kleemola, P. (Päivi); Econs, M.J. (Michael); Harris, T.B. (Tamara); Hunter, D. (David); Loos, R.J.F. (Ruth); Metspalu, A. (Andres); Montgomery, G.W. (Grant); Ridker, P.M. (Paul); Spector, T.D. (Tim); Streeten, E.A. (Elizabeth); Stefansson, K. (Kari); Thorsteinsdottir, U. (Unnur); Uitterlinden, A.G. (André); Widen, E. (Elisabeth); Murabito, J. (Joanne); Ong, K. (Ken)
    In:Nature Genetics, 42(12), 1077 - 1085. ISSN 1061-4036.

    Abstract:

    To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 × 10 -60) and 9q31.2 (P = 2.2 × 10 -33), we identified 30 new menarch

  • The ERCC6 Gene and Age-Related Macular Degeneration (2010)Open access

    Authors:Baas, D.C. (Dominique); Despriet, D.D.G. (Dominique); Gorgels, T.G.M.F. (Theo); Bergeron-Sawitzke, J. (Julie); Uitterlinden, A.G. (André); Hofman, A. (Albert); Duijn, van C.M. (Cock); Merriam, J.E. (Joanna); Smith, R.T. (Theodore); Barile, G.R. (Gaetano); Brink, ten J.B. (Jacoline); Vingerling, J.R. (Hans); Klaver, C.C.W. (Caroline); Allikmets, R. (Rando); Dean, M. (Michael Emmans); Bergen, A.A.B. (Arthur)
    In:PLoS ONE, 5(11), 1 - 9. ISSN 1932-6203.

    Abstract:

    Background: Age-related macular degeneration (AMD) is the leading cause of irreversible visual loss in the developed countries and is caused by both environmental and genetic factors. A recent study (Tuo et al., PNAS) reported an association between AMD and a single nucleotide polymorphism (SNP) (rs

  • Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: Results of a meta-analysis (2010)Open access

    Authors:Kerkhof, H.J.M. (Hanneke); Meulenbelt, I. (Ingrid); Carr, A.M. (Andrew); Gonzalez, A. (Antonio); Hart, D.J. (Deborah); Hofman, A. (Albert); Kloppenburg, M. (Margreet); Lane, N.E.; Loughlin, J. (John); Nevitt, M.C. (Michael); Pols, H.A.P. (Huibert); Rivadeneira Ramirez, F. (Fernando); Slagboom, E. (Eline); Spector, T.D. (Tim); Stolk, L. (Lisette); Tsezou, A. (Aspasia); Uitterlinden, A.G. (André); Valdes, A.M. (Ana Maria); Meurs, van J.B.J. (Joyce)
    In:B M C Medical Genetics, 11(1). ISSN 1471-2350.

    Abstract:

    Background: The objective of this study was to examine the relationship between common genetic variation of the ESR2 gene and osteoarthritis.Methods: In the discovery study, the Rotterdam Study-I, 7 single nucleotide polymorphisms (SNPs) were genotyped and tested for association with hip (284 cases,

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