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Dr. J. van der Vlag Persoon

Dr. J. van der Vlag

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  • Apoptosis-induced acetylation of histones is pathogenic in systemic lupus erythematosus (2007)

    Auteurs:Dieker, J.W.C.; Fransen, J.H.; Bavel, C.C.A.W. van; Briand, J.P.; Jacobs, C.W.M.; Muller, S.; Berden, J.H.M.; Vlag, J. van der
    In:Arthritis and rheumatism, 56, 1921 - 1933. ISSN 0004-3591.

    Samenvatting:

    OBJECTIVE: In systemic lupus erythematosus (SLE), inadequate removal of apoptotic cells may lead to challenge of the immune system with immunogenic self antigens that have been modified during apoptosis. We undertook this study to evaluate whether apoptosis-induced histone modifications are targets

  • Removal of heparan sulfate from the glomerular basement membrane blocks protein passage. (2007)Open access

    Auteurs:Wijnhoven, T.J.M.; Lensen, J.F.M.; Wismans, P.G.P.; Lefeber, D.J.; Rops, A.L.; Vlag, J. van der; Berden, J.H.M.; Heuvel, L.P.W.J. van den; Kuppevelt, A.H.M.S.M. van
    In:Journal of the American Society of Nephrology, 18, 3119 - 3127. ISSN 1046-6673.

    Samenvatting:

    Heparan sulfate (HS) within the glomerular basement membrane (GBM) is thought to play a major role in the charge-selective properties of the glomerular capillary wall. Recent data, however, raise questions regarding the direct role of HS in glomerular filtration. For example, in situ studies suggest

  • Glomerular binding of anti-dsDNA autoantibodies: the dispute resolved? (2007)

    Auteurs:Bavel, C.C.A.W. van; Vlag, J. van der; Berden, J.H.M.
    In:Kidney International, 71, 600 - 601. ISSN 0085-2538.

    Samenvatting:

    The binding of anti-double-stranded DNA (anti-dsDNA) autoantibodies to the glomerular basement membrane (GBM) in lupus nephritis can be explained by two mechanisms: (1) direct crossreactive binding to intrinsic glomerular antigens; (2) nucleosome-mediated binding to heparan sulfate in the GBM. Kalaa

  • Adult and paediatric patients with minimal change nephrotic syndrome show no major alterations in glomerular expression of sulphated heparan sulphate domains. (2007)Open access

    Auteurs:Wijnhoven, T.J.M.; Geelen, J.M.; Bakker, M.; Lensen, J.F.M.; Rops, A.L.; Kramer, A.B.; Navis, G.J.; Hoven, M.J.W. van den; Vlag, J. van der; Berden, J.H.M.; Wetzels, J.F.M.; Heuvel, L.P.W.J. van den; Monnens, L.A.H.; Kuppevelt, A.H.M.S.M. van
    In:Nephrology Dialysis Transplantation, 22, 2886 - 2893. ISSN 0931-0509.

    Samenvatting:

    BACKGROUND: Minimal change nephrotic syndrome (MCNS) is the most frequent form of nephrotic syndrome in childhood. In the glomerular basement membrane (GBM) of adult patients with MCNS, a reduced expression of a specific heparan sulphate (HS) domain has been reported. In children with MCNS, urinary

  • Expression of glomerular heparan sulphate domains in murine and human lupus nephritis. (2007)Open access

    Auteurs:Rops, A.L.; Hoven, M.J.W. van den; Bakker, M.A.H.; Lensen, J.F.M.; Wijnhoven, T.J.M.; Heuvel, L.P.W.J. van den; Kuppevelt, A.H.M.S.M. van; Vlag, J. van der; Berden, J.H.M.
    In:Nephrology Dialysis Transplantation, 22, 1891 - 1902. ISSN 0931-0509.

    Samenvatting:

    BACKGROUND: Recently, we identified specific N- and 6-O-sulphated heparan sulphate (HS) domains on activated glomerular endothelial cells. In this study, we evaluated in lupus nephritis the expression of different HS domains on glomerular endothelium and in the glomerular basement membrane (GBM). ME

  • A prospective study of anti-chromatin and anti-C1q autoantibodies in patients with proliferative lupus nephritis treated with cyclophosphamide pulses or azathioprine/methylprednisolone. (2007)

    Auteurs:Grootscholten, C.; Dieker, J.W.C.; McGrath, F.D.; Roos, A.; Derksen, R.H.W.M.; Vlag, J. van der; Daha, M.R.; Berden, J.H.M.
    In:Annals of the Rheumatic Diseases, 66, 693 - 696. ISSN 0003-4967.

    Samenvatting:

    OBJECTIVE: To study the prevalence and course of anti-chromatin (anti-nucleosome, anti-double-stranded (ds) DNA and anti-histone) and anti-C1q autoantibodies in patients with proliferative lupus nephritis (LN), treated in a randomised controlled trial with either cyclophosphamide or azathioprine plu

  • Syndecan-1 deficiency aggravates anti-glomerular basement membrane nephritis. (2007)

    Auteurs:Rops, A.L.; Gotte, M.; Baselmans, M.H.; Hoven, M.J.W. van den; Steenbergen, E.; Lensen, J.F.M.; Wijnhoven, T.J.M.; Cevikbas, F.; Heuvel, L.P.W.J. van den; Kuppevelt, A.H.M.S.M. van; Berden, J.H.M.; Vlag, J. van der
    In:Kidney International, 72, 1204 - 1215. ISSN 0085-2538.

    Samenvatting:

    During the heterologous phase of experimental anti-glomerular basement membrane (anti-GBM) nephritis, leukocyte influx peaks within hours, whereas albuminuria occurs within 1 day. In the subsequent autologous phase, endogenous anti-GBM IgG develops and albuminuria persists. Heparan sulfate (HS) prot

  • Disruption of glomerular basement membrane charge through podocyte-specific mutation of agrin does not alter glomerular permselectivity. (2007)

    Auteurs:Harvey, S.J.; Jarad, G.; Cunningham, J.; Rops, A.L.; Vlag, J. van der; Berden, J.H.M.; Moeller, M.J.; Holzman, L.B.; Burgess, R.W.; Miner, J.H.
    In:American Journal of Pathology, 171, 139 - 152. ISSN 0002-9440.

    Samenvatting:

    Glomerular charge selectivity has been attributed to anionic heparan sulfate proteoglycans (HSPGs) in the glomerular basement membrane (GBM). Agrin is the predominant GBM-HSPG, but evidence that it contributes to the charge barrier is lacking, because newborn agrin-deficient mice die from neuromuscu

  • In vivo degradation of heparan sulfates in the glomerular basement membrane does not result in proteinuria. (2007)Open access

    Auteurs:Wijnhoven, T.J.M.; Lensen, J.F.M.; Wismans, P.G.P.; Lamrani, M.; Monnens, L.A.H.; Wevers, R.A.; Rops, A.L.; Vlag, J. van der; Berden, J.H.M.; Heuvel, L.P.W.J. van den; Kuppevelt, A.H.M.S.M. van
    In:Journal of the American Society of Nephrology, 18, 823 - 832. ISSN 1046-6673.

    Samenvatting:

    Heparan sulfates (HS) are long, unbranched, negatively charged polysaccharides that are bound to core proteins. HS in the glomerular basement membrane (GBM) is reported to be important for charge-selective permeability. Aberrant GBM HS expression has been observed in several glomerular diseases, suc

  • Anti-proteinuric effects of glycosaminoglycan-based drugs. (2007)

    Auteurs:Wijnhoven, T.J.M.; Lensen, J.F.M.; Rops, A.L.; McCarthy, K.J.; Vlag, J. van der; Berden, J.H.M.; Heuvel, L.P.W.J. van den; Kuppevelt, A.H.M.S.M. van
    In:Current Opinion in Molecular Therapeutics, 9, 364 - 377. ISSN 1464-8431.

    Samenvatting:

    Heparan sulfate (HS) is a member of the family of glycosaminoglycans (GAGs) that is generally bound to a core protein to form a proteoglycan (PG). HSPGs may be cell-membrane associated (glypicans and syndecans) or located within the extracellular matrix (agrin, perlecan and type XVIII collagen). The

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