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Prof.dr. A. Hofman Persoon

Prof.dr. A. Hofman

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  • Selecting subjects for ultrasonographic screening for aneurysms of the abdominal aorta: four different strategies (1999)Open access

    Auteurs:Pleumeekers, H.J.C.M. (Bèr); Hoes, A.W. (Arno); Urk, van H. (Hero); Does, van der E. (Emiel); Grobbee, D.E. (Diederick); Hofman, A. (Albert)
    In:International Journal of Epidemiology. ISSN 0300-5771.

    Samenvatting:

    BACKGROUND: We studied whether the effectiveness of ultrasound screening for abdominal aortic aneurysms could be increased by preselecting high-risk subjects, based on the presence of risk indicators for the disease. METHODS: In a population-based screening programme fo

  • Hormone replacement therapy and intima-media thickness of the common carotid artery: the Rotterdam study (1999)Open access

    Auteurs:Westendorp, I.C.D. (Iris); Veld, in 't B.A.; Bots, M.L. (Michiel); Akkerhuis, J.M.; Grobbee, D.E. (Diederick); Witteman, J.C.M. (Jacqueline); Hofman, A. (Albert)
    In:Stroke, 30(12), 2562 - 2567. ISSN 0039-2499.

    Samenvatting:

    BACKGROUND AND PURPOSE: Observational data suggest that hormone replacement therapy (HRT) reduces morbidity and mortality from cardiovascular disease in healthy postmenopausal women. The mechanisms underlying this protection are not entirely clear but may include

  • Heritabilities of radiologic OA in peripheral joins and of disc degeneration of the spine (1999)Open access

    Auteurs:Bijkerk, C. (Casper); Houwing-Duistermaat, J.J. (Jeanine); Valkenburg, H.A. (Hans); Meulenbelt, I. (Ingrid); Hofman, A. (Albert); Breedveld, F.C. (Ferdinand); Duijn, van C.M. (Cock); Slagboom, P.E. (Eline); Pols, H.A.P. (Huib)
    In:Arthritis Care and Research, 1729 - 1735. ISSN 0004-3591.

    Samenvatting:

    OBJECTIVE: To estimate the genetic influence on the occurrence of radiologic osteoarthritis (ROA) in the knees, hips, and hands and disc degeneration of the spine in the general population. METHODS: A random sample of 1,583 individuals was drawn to estimate the prevalence of ROA and disc degeneratio

  • Prevalence of heart failure and left ventricular dysfunction in the general population; The Rotterdam Study (1999)Open access

    Auteurs:Mosterd, A. (Arend); Hoes, A.W. (Arno); Bruyne, de M.C. (Martine); Linker, D.T.; Grobbee, D.E. (Diederick); Deckers, J.W. (Jaap); Hofman, A. (Albert)
    In:European Heart Journal. ISSN 0195-668x.

    Samenvatting:

    AIMS: To determine the prevalence of heart failure and symptomatic as well as asymptomatic left ventricular systolic dysfunction in the general population. METHODS AND RESULTS: In 5540 participants of the Rotterdam Study (age 68.9+/-8.7 years, 2251 men) aged 55-95 years

  • Presenile Alzheimer dementia characterized by amyloid angiopathy and large amyloid core type senile plaques in the APP 692 Ala => Gly mutation (1998)Open access

    Auteurs:Cras, P. (Patrick); Harskamp, van F. (Frans); Ceuterick, C.; Duijn, van C.M. (Cock); Stefanko, S.Z.; Hofman, A. (Albert); Kros, J.M. (Johan); Broeckhoven, van C. (Christine); Martin, J-J. (Jean-Jacques); Hendriks, L. (Lydia)
    In:Acta Neuropathologica, 96(3), 253 - 260. ISSN 0001-6322.

    Samenvatting:

    Mutations at codons 717 and 670/671 in the amyloid precursor protein (APP) are rare genetic causes of familial Alzheimer's disease (AD). A mutation at codon 693 of APP has also been described as the genetic defect in hereditary cerebral hemorrhage with amyloidosis of the Dutch type (HCHWA-D). We hav

  • Associations of radiological osteoarthritis of the hip and knee with locomotor disability in the Rotterdam Study (1998)Open access

    Auteurs:Odding, E. (Else); Valkenburg, H.A. (Hans); Algra, D.; Vandenouweland, F.A.; Grobbee, D.E. (Diederick); Hofman, A. (Albert)
    In:Annals of the Rheumatic Diseases: an international peer-reviewed journal for health professionals and researchers in the rheumatic diseases. ISSN 0003-4967.

    Samenvatting:

    OBJECTIVE: To assess the contribution of radiological osteoarthritis of the hips and knees to disabilities in the activities of daily living related to lower limb function. METHODS: During a home interview 1156 men and 1739 women, randomly chosen from the source populat

  • A genetic association study of the IGF-1 gene and radiological osteoarthritis in a population-based cohort study (the Rotterdam Study) (1998)Open access

    Auteurs:Meulenbelt, I. (Ingrid); Bijkerk, C. (Casper); Miedema, H.S. (Harald); Breedveld, F.C. (Ferdinand); Valkenburg, H.A. (Hans); Pols, H.A.P. (Huibert); Slagboom, P.E. (Eline); Duijn, van C.M. (Cock); Hofman, A. (Albert)
    In:Annals of the Rheumatic Diseases: an international peer-reviewed journal for health professionals and researchers in the rheumatic diseases, 57(6), 371 - 374. ISSN 0003-4967.

    Samenvatting:

    OBJECTIVE: A genetic association study was performed to investigate whether radiographical osteoarthritis (ROA) was associated with specific genotypes of the insulin-like growth factor I (IGF-1) gene. METHODS: Subjects aged 55-65 years were selected from a population-based study of which ROA at the

  • Relation of alleles of the collagen type Ialpha1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women (1998)Open access

    Auteurs:Uitterlinden, A.G. (André); Burger, H. (Huibert); Huang, Q. (Qiuju); Yue, F. (Fang); McGuigan, F.E.; Grant, S.F.; Pols, H.A.P. (Huibert); Ralston, S.H.; Leeuwen, van J.P.T.M. (Hans); Hofman, A. (Albert)
    In:New England Journal of Medicine. ISSN 0028-4793.

    Samenvatting:

    BACKGROUND: Osteoporosis is a common disorder with a strong genetic component. One way in which the genetic component could be expressed is through polymorphism of COLIA1, the gene for collagen type Ialpha1, a bone-matrix protein. METHODS: We determined the COLIA1 genot

  • A prospective study on cortisol, dehydroepiandrosterone sulfate, and cognitive function in the elderly (1998)Open access

    Auteurs:Kalmijn, S. (Sandra); Launer, L.J. (Lenore); Stolk, R.P. (Ronald); Jong, de F.H. (Frank); Pols, H.A.P. (Huibert); Breteler, M.M.B. (Monique); Lamberts, S.W.J. (Steven); Hofman, A. (Albert)
    In:Journal of Clinical Endocrinology and Metabolism. ISSN 0021-972x.

    Samenvatting:

    The objective of this study was to investigate the relation between the peripheral concentrations of the adrenal steroid hormones cortisol and dehydroepiandrosterone sulfate (DHEAS) and cognitive impairment and decline. A prospective study design was used. The setting w

  • Genetic Risk of age-related maculopathy (1998)

    Auteurs:Klaver, C.C.W. (Caroline); Wolfs, R.C.W. (Roger); Willemse-Assink, J.J.M. (Jacqueline); Duijn, van C.M. (Cock); Hofman, A. (Albert); Jong, de P.T.V.M. (Paulus)
    In:Archives of Ophthalmology, 1646 - 1651. ISSN 0003-9950.

    Samenvatting:

    OBJECTIVE: To investigate to what extent age-related maculopathy (ARM) is genetically determined. DESIGN AND SETTING: Familial aggregation study based on probands derived from the population-based Rotterdam Study. PARTICIPANTS: First-degree relatives of 87 patients with late ARM, i.e., atrophic or n

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