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Prof.dr. A. Hofman Person

Prof.dr. A. Hofman

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  • Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in european ancestry individuals (2011)Open access

    Authors:Arking, D.E. (Dan); Junttila, M.J. (Juhani); Goyette, P. (Philippe); Huertas-Vazquez, A. (Adriana); Eijgelsheim, M. (Mark); Blom, M.T. (Marieke); Newton-Cheh, C. (Christopher); Reinier, K. (Kyndaron); Teodorescu, C. (Carmen); Uy-Evanado, A. (Audrey); Carter-Monroe, N. (Naima); Kaikkonen, K.S. (Kari); Kortelainen, M.-L.; Boucher, G. (Gabrielle); Lagacé, C. (Caroline); Moes, A. (Anna); Zhao, X.; Kolodgie, F. (Frank); Rivadeneira Ramirez, F. (Fernando); Hofman, A. (Albert); Witteman, J.C.M. (Jacqueline); Uitterlinden, A.G. (André); Marsman, R.F. (Roos); Pazoki, R. (Raha); Bardai, A. (Abdennasser); Koster, R.W. (Rudolph); Dehghan, A. (Abbas); Hwang, S.J.; Bhatnagar, P. (Pallav); Post, W. (Wendy); Hilton, G. (Gina); Prineas, R.J. (Ronald); Li, M. (Man); Köttgen, A. (Anna); Ehret, G.B. (Georg); Boerwinkle, E. (Eric); Coresh, J. (Josef); Kao, W.H.L. (Wen); Psaty, B.M. (Bruce); Tomaselli, G.F. (Gordon); Sotoodehnia, N. (Nona); Siscovick, D.S. (David); Burke, G.L. (Greg); Marbán, E. (Eduardo); Spooner, P.M. (Peter); Cupples, L.A. (Adrienne); Jui, J. (Jonathan); Gunson, K. (Karen); Kesaniemi, Y.A. (Antero); Wilde, A.A.M. (Arthur); Tardif, J.C.; O'Donnell, C.J. (Christopher); Bezzina, C.R. (Connie); Virmani, R. (Renu); Stricker, B.H.Ch. (Bruno); Tan, H.L. (Hanno); Albert, C.M. (Christine); Chakravarti, A. (Aravinda); Rioux, J.D. (John); Huikuri, H.V. (Heikki); Chugh, S.S. (Sumeet)
    In:P L o S Genetics (Print), 7(6). ISSN 1553-7390.

    Abstract:

    Sudden cardiac death (SCD) continues to be one of the leading causes of mortality worldwide, with an annual incidence estimated at 250,000-300,000 in the United States and with the vast majority occurring in the setting of coronary disease. We performed a genome-wide association meta-analysis in 1,2

  • Multiple loci are associated with white blood cell phenotypes (2011)Open access

    Authors:Nalls, M.A. (Michael); Couper, D. (David); Tanaka, T. (Toshiko); Rooij, van F.J.A. (Frank); Chen, M-H. (Ming-Huei); Smith, A.V. (Albert Vernon); Toniolo, D. (Daniela); Zakai, N.A. (Neil); Yang, Q. (Qiong Fang); Greinacher, A. (Andreas); Wood, A.R. (Andrew); Garcia, M. (Melissa); Gasparini, P. (Paolo); Liu, Y. (Yongmei); Lumley, T. (Thomas); Folsom, A.R. (Aaron); Reiner, A.P. (Alex); Gieger, C. (Christian); Lagou, V. (Vasiliki); Felix, J.F. (Janine); Völzke, H. (Henry); Gouskova, N.A. (Natalia); Biffi, A. (Alessandro); Döring, A. (Angela); Völker, U. (Uwe); Chong, S. (Sean); Wiggins, K.L. (Kerri); Rendon, A. (Augusto); Dehghan, A. (Abbas); Moore, M. (Matt); Taylor, K.D. (Kent); Wilson, J.G. (James); Lettre, G. (Guillaume); Hofman, A. (Albert); Bis, J.C. (Joshua); Pirastu, N. (Nicola); Fox, C.S. (Caroline); Meisinger, C. (Christa); Sambrook, J.G. (Jennifer); Arepalli, S. (Sampath); Nauck, M. (Matthias); Prokisch, H. (Holger); Stephens, J. (Jonathan); Glazer, N.L. (Nicole); Cupples, L.A. (Adrienne); Okada, Y. (Yukinori); Takahashi, A. (Atsushi); Kamatani, Y. (Yoichiro); Matsuda, K. (Koichi); Tsunoda, T. (Tatsuhiko); Kubo, M. (Michiaki); Nakamura, Y. (Yusuke); Yamamoto, K. (Kazuhiko); Stumvoll, M. (Michael); Tönjes, A. (Anke); Prokopenko, I. (Inga); Illig, T. (Thomas); Patel, K.V. (Kushang); Garner, S.F. (Stephen); Kuhnel, B. (Brigitte); Mangino, M. (Massimo); Oostra, B.A. (Ben); Thein, S.L.; Coresh, J. (Josef); Wichmann, H.E. (Heinz Erich); Menzel, S. (Stephan); Lin, J.; Pistis, G. (Giorgio); Uitterlinden, A.G. (André); Spector, T.D. (Timothy); Teumer, A. (Alexander); Eiriksdottir, G. (Gudny); Gudnason, V. (Vilmundur); Bandinelli, S. (Stefania); Frayling, T.M. (Timothy); Chakravarti, A. (Aravinda); Tikka-Kleemola, P. (Päivi); Melzer, D. (David); Ouwehand, W.H. (Willem); Levy, D. (Daniel); Boerwinkle, E. (Eric); Singleton, A. (Andrew); Hernandez, D.G. (Dena); Longo, D.L. (Dan); Soranzo, N. (Nicole); Witteman, J.C.M. (Jacqueline); Psaty, B.M. (Bruce); Ferrucci, L. (Luigi); Harris, T.B. (Tamara); O'Donnell, C.J. (Christopher); Ganesh, S.K. (Santhi)
    In:P L o S Genetics (Print), 7(6). ISSN 1553-7390.

    Abstract:

    White blood cell (WBC) count is a common clinical measure from complete blood count assays, and it varies widely among healthy individuals. Total WBC count and its constituent subtypes have been shown to be moderately heritable, with the heritability estimates varying across cell types. We studied 1

  • Age, gender and disability predict future disability in older people: The Rotterdam Study (2011)

    Authors:Taş, U. (Ümit); Steyerberg, E.W. (Ewout); Bierma-Zeinstra, S.M. (Sita); Hofman, A. (Albert); Koes, B.W. (Bart); Verhagen, A.P. (Arianne)
    In:BMC Geriatrics, 11. ISSN 1471-2318.

    Abstract:

    Background: To develop a prediction model that predicts disability in community-dwelling older people. Insight in the predictors of disability is needed to target preventive strategies for people at increased risk. Methods. Data were obtained from the Rotterdam Study, including subjects of 55 years

  • De genetica van ondernemerschap (2011)Open access

    Authors:Loos, van der M.J.H.M. (Matthijs); Groenen, P.J.F. (Patrick); Hofman, A. (Albert); Koellinger, Ph.D. (Philipp); Rivadeneira Ramirez, F. (Fernando); Rooij, van F.J.A. (Frank); Thurik, A.R. (Roy); Uitterlinden, A.G. (André)
    In:Economisch-Statistische Berichten, 96(4609s), 30 - 36. ISSN 0013-0583.

    Abstract:

    genetiGenoombreed associatieonderzoek is een moderne onderzoeksmethode die het mogelijk maakt genen te vinden die geassocieerd zijn met allerlei ziekten en menselijke eigenschappen. Een samenwerkingsverband tussen de Erasmus School of Economics en het Erasmus Medisch Centrum probeert deze veelbelove

  • Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption (2011)

    Authors:Schumann, G. (Gunter); Coin, L. (Lachlan); Lourdusamy, A. (Anbarasu); Charoen, P. (Pimphen); Berger, K.H. (Karen); Stacey, D. (David); Desrivières, S. (Sylvane); Aliev, F.A. (Fazil); Khan, A.A. (Anokhi); Amin, N. (Najaf); Bakalkin, G. (Georgy); Balkau, B. (Beverley); Beulens, J.W.J. (Joline); Bilbao, A. (Ainhoa); Boer, de R.A.; Beury, D. (Delphine); Bots, M.L. (Michiel); Breetvelt, E.J. (Elemi); Cauchi, S. (Stephane); Cavalcanti-Proença, C. (Christine); Chambers, J.C. (John); Clarke, T.-K.; Dahmen, N. (N.); Geus, de E.J.C. (Eco); Dick, D. (Danielle); Ducci, F. (Francesca); Easton, A. (Alanna); Edenberg, H.J. (Howard); Esk, T. (Tõnu); Fernández-Medarde, A. (Alberto); Foroud, T. (Tatiana); Freimer, N.B. (Nelson); Girault, J.-A.; Grobbee, D.E. (Diederick); Guarrera, S. (Simonetta); Gudbjartsson, D.F. (Daniel); Hartikainen, A.L.; Heath, A.C. (Andrew); Hesselbrock, V. (Victor); Hofman, A. (Albert); Hottenga, J.J.; Isohanni, M.K. (Matti); Kaprio, J. (Jaakko); Khaw, K-T. (Kay-Tee); Kuehnel, B. (Brigitte); Laitinen, J. (Jaana); Lobbens, S. (Stéphane); Luan, J.; Mangino, M. (Massimo); Maroteaux, M. (Matthieu); Matullo, G. (Giuseppe); McCarthy, M.I. (Mark); Mueller, C. (Christian); Navis, G. (Gerjan); Numans, M.E. (Mattijs); Núñez, A. (Alejandro); Nyholt, D.R. (Dale); Onland-Moret, C.N. (Charlotte); Oostra, B.A. (Ben); O'Reilly, P.F. (Paul); Palkovits, M. (Miklos); Penninx, B.W.J.H. (Brenda); Polidoro, S. (Silvia); Pouta, A. (Anneli); Prokopenko, I. (Inga); Ricceri, F. (Fulvio); Santos, E. (Eugenio); Smit, J.H. (Johannes); Soranzo, N. (Nicole); Song, K. (Kijoung); Sovio, U. (Ulla); Stumvoll, M. (Michael); Surakk, I. (Ida); Thorgeirsson, T.E. (Thorgeir); Thorsteinsdottir, U. (Unnur); Troakes, C. (Claire); Tyrfingsson, T. (Thorarinn); Tönjes, A. (Anke); Uiterwaal, C.S.P.M. (Cuno); Uitterlinden, A.G. (André); Harst, van der P. (Pim); Schouw, van der Y.T. (Yvonne); Staehlin, O. (Oliver); Vogelzangs, N. (Nicole); Vollenweider, P. (Peter); Waeber, G. (Gérard); Wareham, N.J. (Nicholas); Waterworth, D. (Dawn); Whitfield, J.B. (John); Wichmann, E.H. (Erich); Willemsen, G.A.H.M. (Gonneke); Witteman, J.C.M. (Jacqueline); Yuan, X. (Xin); Zhai, G. (Guangju); Zhao, J.H. (Jing); Zhang, W. (Weihua); Martin, N.G. (Nicholas); Metspalu, A. (Andres); Doering, A. (Angela); Scott, J. (James); Spector, T.D. (Timothy); Loos, R.J.F. (Ruth); Boomsma, D.I. (Dorret); Mooser, V. (Vincent); Peltonen, L. (Leena Johanna); Stefansson, K. (Kari); Tikka-Kleemola, P. (Päivi); Vineis, P. (Paolo); Sommer, W.H. (Wolfgang); Kooner, J.S. (Jaspal); Spanagel, R. (Rainer); Heberlein, U.A. (Ulrike); Järvelin, M.R.; Elliott, P. (Paul); Aulchenko, Y.S. (Yurii); Bakker, S.J.L. (Stephan)
    In:Proceedings of the National Academy of Sciences of the United States of America, 108(17), 7119 - 7124. ISSN 0027-8424.

    Abstract:

    Alcohol consumption is a moderately heritable trait, but the genetic basis in humans is largely unknown, despite its clinical and societal importance. We report a genome-wide association study meta-analysis of ∼2.5 million directly genotyped or imputed SNPs with alcohol consumption (gram per day per

  • Genetic predictors of fibrin D-dimer levels in healthy adults (2011)

    Authors:Smith, N.L.; Huffman, J.E.; Strachan, D.P.; Huang, J.; Dehghan, A.; Trompet, S.; Lopez, L.M.; Shin, S.Y.; Baumert, J.; Vitart, V.; Bis, J.C.; Wild, S.H.; Rumley, A.; Yang, Q.; Uitterlinden, A.G.; Stott, D.J.; Davies, G.; Carter, A.M.; Thorand, B.; Polašek, O.; McKnight, B.; Campbell, H.; Rudnicka, A.R.; Chen, M.H.; Buckley, B.M.; Harris, S.E.; Peters, A.; Pulanic, D.; Lumley, T.; de Craen, A.J.M.; Liewald, D.C.; Gieger, C.; Ford, I.; Gow, A.J.; Luciano, M.; Porteous, D.J.; Guo, X.; Sattar, N.; Tenesa, A.; Cushman, M.; Slagboom, P.E.; Visscher, P.M.; Spector, T.D.; Illig, T.; Rudan, I.; Bovill, E.G.; Wright, A.F.; McArdle, W.L.; Tofler, G.H.; Hofman, A.; Westendorp, R.G.J.; Starr, J.M.; Grant, P.J.; Karakas, M.; Hastie, N.D.; Psaty, B.M.; Wilson, J.F.; Lowe, G.D.O.; O'Donnell, C.J.; Witteman, J.C.M.; Jukema, J.W.; Deary, I.J.; Soranzo, N.; Koenig, W.; Hayward, C.
    In:Circulation (Baltimore). ISSN 0009-7322.

    Abstract:

    BACKGROUND: Fibrin fragment D-dimer, one of several peptides produced when crosslinked fibrin is degraded by plasmin, is the most widely used clinical marker of activated blood coagulation. To identity genetic loci influencing D-dimer levels, we performed the first large-scale, genome-wide associati

  • Maternal smoking during pregnancy and subcutaneous fat mass in early childhood. The Generation R Study (2011)Open access

    Authors:Durmus, B.; Ay, L.; Hokken-Koelega, A.C.S. (Anita); Raat, H. (Hein); Hofman, A. (Albert); Steegers-Theunissen, R.P.M. (Regine); Jaddoe, V.W.V. (Vincent)
    In:European Journal of Epidemiology, 26(4), 295 - 304. ISSN 0393-2990.

    Abstract:

    Maternal smoking during pregnancy increases the risk of obesity in the offspring. Not much is known about the associations with other measures of body composition. We assessed the associations of maternal smoking during pregnancy with the development of subcutaneous fat mass measured as peripheral a

  • Eight common genetic variants associated with serum dheas levels suggest a key role in ageing mechanisms (2011)Open access

    Authors:Zhai, G. (Guangju); Teumer, A. (Alexander); Stolk, L. (Lisette); Perry, J.R.B. (John); Vandenput, L. (Liesbeth); Coviello, A.D. (Andrea); Koster, A. (Annemarie); Bell, J.T. (Jordana); Bhasin, S. (Shalender); Eriksson, J. (Joel); Ernst, F.D.J. (Florian); Ferrucci, L. (Luigi); Frayling, T.M. (Timothy); Glass, D. (Daniel); Grundberg, E. (Elin); Haring, R. (Robin); HedmanÅ, A.K.; Hofman, A. (Albert); Kiel, D.P. (Douglas); Kroemer, H.K. (Heyo); Liu, Y. (Yongmei); Lunetta, K.L. (Kathryn); Maggio, M. (Marcello); Lorentzon, M. (Mattias); Mangino, M. (Massimo); Melzer, D. (David); Miljkovic, I. (Iva); Nica, A. (Alexandra); Penninx, B.W.J.H. (Brenda); Vasan, R.S. (Ramachandran Srini); Rivadeneira Ramirez, F. (Fernando); Small, K.S. (Kerrin); Soranzo, N. (Nicole); Uitterlinden, A.G. (André); Völzke, H. (Henry); Wilson, S.G. (Scott); Xi, L. (Li); Zhuang, W.V.; Jong, de F.H. (Frank); Harris, T.B. (Tamara); Murabito, J. (Joanne); Ohlsson, C. (Claes); Murray, A. (Anna); Spector, T.D. (Timothy); Wallaschofski, H. (Henri)
    In:P L o S Genetics (Print), 7(4). ISSN 1553-7390.

    Abstract:

    Dehydroepiandrosterone sulphate (DHEAS) is the most abundant circulating steroid secreted by adrenal glands-yet its function is unknown. Its serum concentration declines significantly with increasing age, which has led to speculation that a relative DHEAS deficiency may contribute to the development

  • Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk (2011)Open access

    Authors:Duncan, E.L. (Emma); Danoy, P. (Patrick); Kemp, J.P. (John); Leo, P.J. (Paul); McCloskey, E. (Eugene); Nicholson, G.C. (Geoffrey); Eastell, R. (Richard); Prince, R.L. (Richard); Eisman, J.A. (John); Jones, G. (Graeme); Sambrook, P.N. (Philip); Reid, I.R. (Ian); Dennison, E.M. (Elaine); Wark, J. (John); Richards, J.B. (Brent); Uitterlinden, A.G. (André); Spector, T.D. (Timothy); Esapa, C. (Chris); Cox, R.D. (Roger); Brown, S.D.M. (Steve); Thakker, R.V. (Rajesh); Addison, K.A. (Kathryn); Bradbury, L.A. (Linda); Center, J.R. (Jacqueline); Cooper, C. (Cyrus); Cremin, C. (Catherine); Estrada Gil, K. (Karol); Felsenberg, D. (Dieter); Glüer, C.-C. (Claus-); Hadler, J. (Johanna); Henry, M.J. (Margaret); Hofman, A. (Albert); Kotowicz, M.A. (Mark); Makovey, J. (Joanna); Nguyen, S.C. (Sing); Pasco, J.A. (Julie); Pryce, K. (Karena); Rivadeneira Ramirez, F. (Fernando); Roux, C. (Christian); Stefansson, K. (Kari); Styrkarsdottir, U. (Unnur); Thorleifsson, G. (Gudmar); Tichawangana, R. (Rumbidzai); Evans, D.M. (David)
    In:P L o S Genetics (Print), 7(4). ISSN 1553-7390.

    Abstract:

    Osteoporotic fracture is a major cause of morbidity and mortality worldwide. Low bone mineral density (BMD) is a major predisposing factor to fracture and is known to be highly heritable. Site-, gender-, and age-specific genetic effects on BMD are thought to be significant, but have largely not been

  • Association of an APOC3 promoter variant with type 2 diabetes risk and need for insulin treatment in lean persons (2011)Open access

    Authors:Hoek, M. van; Herpt, T.W. van; Dehghan, A.; Hofman, A.; Lieverse, A.; Duijn, C.M. van; Witteman, J.C.M.; Sijbrands, E.J.G.
    In:Diabetologia: clinical and experimental diabetes and metabolism, 1 - 8. ISSN 0012-186x.

    Abstract:

    Aims/hypothesis: An APOC3 promoter haplotype has been previously associated with type 1 diabetes. In this population-based study, we investigated whether APOC3 polymorphisms increase type 2 diabetes risk and need for insulin treatment in lean participants. Methods: In the Rotterdam Study, a populati

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