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Prof.dr. A. Hofman Persoon

Prof.dr. A. Hofman

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  • The Generation R Study: Design and cohort update 2010 (2010)Open access

    Auteurs:Jaddoe, V.W.V. (Vincent); Duijn, van C.M. (Cock); Heijden, van der A.J. (Bert); Mackenbach, J.P. (Johan); Moll, H.A. (Henriëtte); Steegers-Theunissen, R.P.M. (Regine); Tiemeier, H. (Henning); Uitterlinden, A.G. (André); Verhulst, F.C. (Frank); Hofman, A. (Albert)
    In:European Journal of Epidemiology, 25(11), 823 - 841. ISSN 0393-2990.

    Samenvatting:

    The Generation R Study is a population-based prospective cohort study from fetal life until young adulthood. The study is designed to identify early environmental and genetic causes of normal and abnormal growth, development and health during fetal life, childhood and adulthood. The study focuses on

  • Heart failure and the risk of stroke: the Rotterdam Study (2010)Open access

    Auteurs:Alberts, V.P.; Bos, M.J. (Michiel); Koudstaal, P.J. (Peter); Hofman, A. (Albert); Witteman, J.C.M. (Jacqueline); Stricker, B.H.Ch. (Bruno); Breteler, M.M.B. (Monique)
    In:European Journal of Epidemiology, 25(11), 807 - 812. ISSN 0393-2990.

    Samenvatting:

    Patients with heart failure used to have an increased risk of stroke, but this may have changed with current treatment regimens. We assessed the association between heart failure and the risk of stroke in a population-based cohort that was followed since 1990. The study uses the cohort of the Rotter

  • National origin and behavioural problems of toddlers: The role of family risk factors and maternal immigration characteristics (2010)Open access

    Auteurs:Jansen, P.W. (Pauline); Raat, H. (Hein); Mackenbach, J.P. (Johan); Jaddoe, V.W.V. (Vincent); Hofman, A. (Albert); Oort, van F.V.A. (Floortje); Verhulst, F.C. (Frank); Tiemeier, H. (Henning)
    In:Journal of Abnormal Child Psychology, 38(8), 1151 - 1164. ISSN 0091-0627.

    Samenvatting:

    In many societies the prevalence of behavioural problems in school-aged children varies by national origin. We examined the association between national origin and behavioural problems in 11/2-year-old children. Data on maternal national origin and the Child Behavior Checklist for toddlers (n = 4943

  • Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index (2010)

    Auteurs:Speliotes, E.K. (Elizabeth); Willer, C.J. (Cristen); Berndt, S.I. (Sonja); Monda, K.L. (Keri); Thorleifsson, G. (Gudmar); Jackson, A.U. (Anne); Allen, H.L.; Lindgren, C.M. (Cecilia); Luan, J.; Mägi, R. (Reedik); Randall, J.C. (Joshua); Vedantam, S. (Sailaja); Winkler, T. (Thomas); Qi, L. (Lu); Workalemahu, T. (Tsegaselassie); Heid, I.M. (Iris); Steinthorsdottir, V. (Valgerdur); Stringham, H.M. (Heather); Weedon, M.N. (Michael); Wheeler, E. (Eleanor); Wood, A.R. (Andrew); Ferreira, T. (Teresa); Weyant, R.J. (Robert); Segrè, A.V. (Ayellet); Eestrada, K. (Karol); Liang, L. (Liming); Nemesh, J. (James); Park, J.H.; Gustafsson, S. (Stefan); Kilpeläinen, T.O. (Tuomas); Yang, J. (Joanna); Bouatia-Naji, N. (Nabila); Eesko, T. (Tõnu); Feitosa, M.F. (Mary Furlan); Kutalik, Z. (Zoltán); Mangino, M. (Massimo); Raychaudhuri, S. (Soumya); Scherag, A. (Andre); Smith, A.V. (Albert Vernon); Welch, R.P. (Ryan); Zhao, J.H.; Aben, K.K.H. (Katja); Absher, D. (Devin); Amin, N. (Najaf); Dixon, A.L. (Anna); Fisher, E. (Eeva); Glazer, N.L. (Nicole); Goddard, M.E. (Michael); Heard-Costa, N.L. (Nancy); Hoesel, V. (Volker); Hottenga, J.J.; Johansson, A. (Åsa); Johnson, T. (Toby); Ketkar, S. (Shamika); Lamina, C. (Claudia); Li, S. (Shengxu); Moffatt, M.F. (Miriam); Myers, R.H. (Richard); Narisu, N. (Narisu); Perry, J.R.B. (John); Peters, M.J. (Marjolein); Preuss, M. (Michael); Ripatti, S. (Samuli); Rivadeneira Ramirez, F. (Fernando); Sandholt, C. (Camilla); Scott, L.J. (Laura); Timpson, N. (Nicholas); Tyrer, J.P. (Jonathan); Wingerden, van S. (Sophie); Watanabe, R.M. (Richard); White, C.C. (Charles); Wiklund, F. (Fredrik); Barlassina, C. (Christina); Chasman, D.I. (Daniel); Cooper, M.N. (Matthew); Jansson, J.O.; Lawrence, R.W. (Robert); Pellikka, N. (Niina); Prokopenko, I. (Inga); Shi, J. (Jianxin); Thiering, E. (Eelisabeth); Alavere, H. (Helene); Alibrandi, M.T.S. (Maria); Almgren, P. (Peter); Arnold, A.M. (Alice); Aspelund, T. (Thor); Atwood, L.D. (Larry); Balkau, B. (Beverley); Balmforth, A.J. (Anthony); Bennett, A.J. (Amanda); Ben-Shlomo, Y.; Bergman, R.N. (Richard); Bergmann, S. (Sven); Biebermann, H. (Heike); Blakemore, A.I.F. (Alexandra); Boes, T. (Tanja); Bonnycastle, L.L. (Lori); Bornstein, S.R. (Stefan); Brown, M.J. (Morris); Buchanan, T.A. (Thomas); Busonero, F.; Campbell, H. (Harry); Cappuccio, F.P. (Francesco); Cavalcanti-Proença, C. (Christine); Ida Chen, Y.D.; Chen, C.; Chines, P.S. (Peter); Clarke, R.; Coin, L. (Lachlan); Connell, J. (John); Day, I.N.M. (Ian); Heijer, den M. (Martin); Duan, J. (Jubao); Eebrahim, S. (Shah); Eelliott, P. (Paul); Eelosua, R. (Roberto); Eeiriksdottir, G. (Gudny); Eerdos, M.R. (Micheal); Eeriksson, J.G. (Johan); Facheris, M.F. (Maurizio); Felix, S.B. (Stephan); Fischer-Posovszky, P. (Pamela); Folsom, A.R. (Aaron); Friedrich, N. (Nele); Freimer, N.B. (Nelson); Fu, M. (Mao); Gaget, S. (Stefan); Gejman, P.V. (Pablo); Geus, E.J. (Eeco); Gieger, C. (Christian); Gjesing, A.P. (Anette); Goel, A. (Anuj); Goyette, P. (Philippe); Grallert, H. (Harald); Gräßler, J. (Jürgen); Greenawalt, D. (Danielle); Groves, C.J. (Christopher); Gudnason, V. (Vilmundur); Guiducci, C. (Candace); Hartikainen, A.L.; Hassanali, N. (Neelam); Hall, A.S. (Alistair); Havulinna, A.S. (Aki); Hayward, C. (Caroline); Heath, A.C. (Andrew); Hengstenberg, C. (Christian); Hicks, A.A. (Andrew); Hinney, A. (Anke); Hofman, A. (Albert); Homuth, G. (Georg); Hui, J. (Jennie); Igl, W. (Wilmar); Iribarren, C. (Carlos); Isomaa, B. (Bo); Jacobs, K.B. (Kevin); Jarick, I. (Ivonne); Jewell, E. (Eelizabeth); John, U. (Ulrich); Jørgensen, T. (Torben); Jousilahti, P. (Pekka); Jula, A. (Antti); Kaakinen, M. (Marika); Kajantie, E. (Eero); Kaplan, R.; Kathiresan, S. (Sekar); Kettunen, J. (Johannes); Kinnunen, L. (Leena); Knowles, J.W. (Joshua); Kolcic, I. (Ivana); König, I.R. (Inke); Koskinen, S. (Seppo); Kovacs, P. (Peter); Kusisto, J. (Johanna); Kraft, P. (Peter); Kvaløy, K. (Kirsti); Laitinen, J. (Jaana); Lantieri, O. (Olivier); Lanzani, C. (Chiara); Launer, L.J. (Lenore); Lecoeur, C. (Cécile); Lehtimäki, T. (Terho); Lettre, G. (Guillaume); Liu, J. (Jianjun); Lokki, M.L.; Lorentzon, M. (Mattias); Luben, R.N. (Robert); Ludwig, B. (Barbara); Magic, ; Manunta, P. (Paolo); Marek, D. (Diana); Marre, M. (Michel); Martin, N.G. (Nicholas); McArdle, W.L. (Wendy); McCarthy, M.I. (Mark); McKnight, B. (Barbara); Meitinger, T. (Thomas); Melander, O. (Olle); Meyre, D. (David); Midthjell, K. (Kristian); Montgomery, G.W. (Grant); Morken, M.A. (Mario); Morris, A.D. (Andrew); Mulic, R. (Rosanda); Ngwa, J.S.; Nelis, M. (Mari); Neville, M.J. (Matthew); Nyholt, D.R. (Dale); O'Ddonnell, C.J. (Christopher); O'Rahilly, S. (Stephen); Ong, K. (Ken); Ostra, B. (Ben); Paré, G. (Guillaume); Parker, A.N. (Alex); Perola, M. (Markus); Pichler, I. (Irene); Pietilainen, K.H. (Kirsi Hannele); Platou, C.P. (Carl); Polasek, O. (Ozren); Pouta, A. (Anneli); Rafelt, S. (Suzanne); Raitakari, O. (Olli); Rayner, N.W. (N William); Ridderstråle, M. (Martin); Rief, W. (Winfried); Ruokonen, A. (Aimo); Robertson, N.R. (Neil); Rzehak, P. (Peter); Salomaa, V. (Veikko); Sanders, A.R. (Alan); Sandhu, M.S. (Manjinder); Sanna, S.; Saramies, J. (Jouko); Savolainen, M.J. (Markku); Schipf, S. (Sabine); Schreiber, S. (Stefan); Schunkert, H. (Heribert); Silander, K. (Kaisa); Sinisalo, J. (Juha); Siscovick, D.S. (David); Smit, J.H. (Jan); Soranzo, N. (Nicole); Sovio, U. (Ulla); Stephens, J. (Jonathan); Surakka, I. (Ida); Swift, A.J. (Amy); Tammesoo, M.L.; Tardif, J.C.; Teder-Laving, M. (Maris); Teslovich, T.M. (Tanya); Thompson, J.R. (John); Thomson, B. (Brian); Tönjes, A. (Anke); Tuomi, T. (Tiinamaija); Meurs, van J.B.J. (Joyce); OMen, van G.J.; Vatin, V. (Vincent); Viikari, J. (Jorma); Visvikis-Siest, S. (Sophie); Vitart, V. (Veronique); Vogel, C.I. (Carla); Voight, B.F. (Benjamin); Waite, L. (Lindsay); Wallaschofski, H. (Henri); Walters, G.B. (Bragi); Widen, E. (Elisabeth); Wiegand, S. (Susanna); Wild, S.H. (Sarah); Willemsen, G.A.H.M. (Gonneke); Witte, D.R. (Deniel); Witteman, J.C.M. (Jacqueline); Xu, J. (Jianfeng); Zhang, Q. (Qunyuan); Zgaga, L. (Lina); Ziegler, A.; Zitting, P. (Paavo); Beilby, J.P. (John); FarOqi, I.S. (Ssadaf); Hebebrand, J. (Johannes); Huikuri, H.V. (Heikki); James, A. (Alan); Kähönen, M. (Mika); Levinson, D.F. (Douglas); MacCiardi, F. (Fabio); Nieminen, M.S. (Markku); Ohlsson, C. (Claes); Palmer, C. (Cameron); Ridker, P.M. (Paul); Stumvoll, M. (Michael); Beckmann, J.S. (Jacques); Boeing, H.; Boerwinkle, E. (Eric); BOmsma, D.I. (Dorret); Caulfield, M. (Mark); Chanock, S.J. (Stephen); Collins, F.S. (Francis); Cupples, L.A. (Adrienne); Eerdmann, J. (Jeanette); Frogue, P. (Philippe); Grönberg, H. (Henrik); Gyllensten, U. (Ulf); Hansen, T. (Torben); Harris, T.B. (Tamara); Hattersley, A.T. (Andrew); Hayes, R.B. (Richard); Heinrich, J. (Joachim); Hu, F.B. (Frank); Hveem, K. (Kristian); Illig, T. (Thomas); Järvelin, M.R.; Kaprio, J. (Jaakko); Karpe, F. (Fredrik); Khaw, K-T. (Kay-Tee); Kiemeney, L.A.L.M. (Bart); Krude, H.; Laakso, M. (Markku); Lawlor, D.A. (Debbie); Metspalu, A. (Andres); Munroe, P. (Patricia); Ouwehand, W.H. (Willem); Pedersen, O. (Oluf); Penninx, B.W.J.H. (Brenda); Pramstaller, P.P. (Peter Paul); Quertermous, T. (Thomas); Reinehr, T. (Thomas); Rissanen, A. (Aila); Rudan, I. (Igor); Samani, N.J. (Nilesh); Schwarz, P.E.H. (Peter); Shuldiner, A.R. (Alan); Spector, T.D. (Timothy); Tuomilehto, J. (Jaakko); Uda, M.; Uitterlinden, A.G. (André); Valle, T.T. (Timo); Wabitsch, M. (Martin); Waeber, G. (Gérard); Wareham, N.J. (Nicholas); Watkins, H. (Hugh); Wilson, J.F. (James); Wright, A.F. (Alan); Zillikens, M.C. (Carola); ChatterjE, N. (Nilanjan); McCarroll, S.A. (Steve); Purcell, S. (Shaun); Schadt, E.E. (Eric); Visscher, P.M. (Peter); Assimes, T.L. (Themistocles); Borecki, I.B. (Ingrid); Deloukas, P. (Panagiotis); Fox, C.S. (Caroline); Groop, L. (Leif); Haritunians, T. (Talin); Hunter, D.J. (David); Mohlke, K.L. (Karen); O'ConneL, J.R. (Jeffrey); Peltonen, L. (Leena Johanna); SchleSinger, D. (David); Strachan, D.P. (David); Duijn, van C.M. (Cock); Wichmann, H.E. (Heinz Erich); Frayling, T.M. (Timothy); Thorsteinsdottir, U. (Unnur); Abecasis, G.R. (Gonçalo); Boehnke, M. (Michael); StefanSon, K. (Kari); North, K.E. (Kari); McArthy, M.I. (Mark); Hirschhorn, J.N. (Joel); IngelSon, E. (Erik); Loos, R.J.F. (Ruth)
    In:Nature Genetics, 42(11), 937 - 948. ISSN 1061-4036.

    Samenvatting:

    Obesity is globaLy prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined aSociations betwEn body maS index and ĝ̂1/42.8 miLion SNPs in up to 123,865 individuals with targeted foLow up of 42 SNPs in

  • Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution (2010)

    Auteurs:Heid, I.M. (Iris); Jackson, A.U. (Anne); Randall, J.C. (Joshua); Winkler, T. (Thomas); Qi, L. (Lu); Ssteinthorsdottir, V. (Valgerdur); Tthorleifsson, G. (Ggudmar); Zillikens, M.C. (Carola); Sspeliotes, E.K. (Eelizabeth); Mägi, R. (Reedik); Workalemahu, T. (Tsegaselassie); White, C.C. (Charles); Bouatia-Naji, N. (Nabila); Harris, T.B. (Tamara); Berndt, S.I. (Sonja); Ingelsson, E. (Erik); Willer, C.J. (Cristen); Weedon, M.N. (Michael); Luan, J.; Vedantam, S. (Sailaja); Eesko, T. (Tõnu); Kilpeläinen, T.O. (Tuomas); Kutalik, Z. (Zoltán); Li, S. (Shengxu); Monda, K.L. (Keri); Dixon, A.L. (Anna); Holmes, C. (Christopher); Kaplan, R.; Liang, L. (Liming); Min, J. (Josine); Moffatt, M.F. (Miriam); Molony, C. (Cliona); Nicholson, G. (Ggeorge); Sschadt, E.E. (Eeric); Zondervan, K.T. (Krina); Feitosa, M.F. (Mary Furlan); Ferreira, T. (Teresa); Allen, H.L.; Weyant, R.J. (Robert); Wheeler, E. (Eleanor); Wood, A.R. (Andrew); Magic, ; Eestrada, K. (Karol); Goddard, M.E. (Michael); Lettre, G. (Guillaume); Mangino, M. (Massimo); Nyholt, D.R. (Dale); Purcell, S. (Shaun); Ssmith, A.V.; Visscher, P.M. (Peter); Yang, J. (Joanna); McCcarroll, S.A. (Ssteven); Nemesh, J. (James); Voight, B.F. (Benjamin); Absher, D. (Devin); Amin, N. (Najaf); Aspelund, T. (Thor); Coin, L. (Lachlan); Glazer, N.L. (Nicole); Hayward, C. (Caroline); Heard-Ccosta, N. (Nancy); Hottenga, J.J.; Johansson, A. (Åsa); Johnson, T. (Toby); Kaakinen, M. (Marika); Kapur, K. (Karen); Ketkar, S. (Shamika); Knowles, J.W. (Joshua); Kraft, P. (Peter); Kraja, A. (Aldi); Lamina, C. (Claudia); Leitzmann, M.F. (Michael); McKknight, B. (Barbara); Morris, A.D. (Andrew); Oong, K. (Ken); Perry, J.R.B. (John); Peters, M.J. (Marjolein); Polasek, O. (Ozren); Prokopenko, I. (Inga); Rayner, N.W. (N William); Ripatti, S. (Samuli); Rivadeneira Ramirez, F. (Fernando); Robertson, N.R. (Neil); Sanna, S.; Sovio, U. (Ulla); Surakka, I. (Ida); Teumer, A. (Alexander); Wingerden, van S. (Sophie); Vitart, V. (Veronique); Zhao, J.H.; Cavalcanti-Proença, C. (Christine); Chines, P.S. (Peter); Fisher, E. (Eeva); Kulzer, J.R. (Jennifer); Lecoeur, C. (Cécile); Narisu, N. (Narisu); Sandholt, C. (Camilla); Scott, L.J. (Laura); Silander, K. (Kaisa); Stark, K. (Klaus); Tammesoo, M.L.; Teslovich, T.M. (Tanya); Timpson, N. (Nicholas); Watanabe, R.M. (Richard); Welch, R.P. (Ryan); Chasman, D.I. (Daniel); Cooper, M.N. (Matthew); Jansson, J.O.; Kettunen, J. (Johannes); Wlawrence, R. (Robert); Pellikka, N. (Niina); Perola, M. (Markus); Vandenput, L. (Liesbeth); Alavere, H. (Helene); Almgren, P. (Peter); Atwood, L.D. (Larry); Bennett, A.J. (Amanda); Biffar, R. (Reiner); Bonnycastle, L.L. (Lori); Bornstein, S.R. (Stefan); Buchanan, T.A. (Thomas); Campbell, H. (Harry); Day, I.N.M. (Ian); Dei, M. (Mariano); Dörr, M. (Marcus); Eelliott, P. (Paul); Eerdos, M.R. (Micheal); Eeriksson, J.G. (Johan); Freimer, N.B. (Nelson); Fu, M. (Mao); Gaget, S. (Stefan); Geus, E.J.C. (Eco); Gjesing, A.P. (Anette); Grallert, H. (Harald); Gräßler, J. (Jürgen); Groves, C.J. (Christopher); Guiducci, C. (Candace); Hartikainen, A.L.; Hassanali, N. (Neelam); Havulinna, A.S. (Aki); Herzig, K.H.; Hicks, A.A. (Andrew); Hui, J. (Jennie); Igl, W. (Wilmar); Jousilahti, P. (Pekka); Jula, A. (Antti); Kajantie, E. (Eero); Kinnunen, L. (Leena); Kolcic, I. (Ivana); Koskinen, S. (Seppo); Kovacs, P. (Peter); Kroemer, H.K. (Heyo); Krzelj, V. (Vjekoslav); Kuusisto, J. (Johanna); Kvaløy, K. (Kirsti); Laitinen, J. (Jaana); Lantieri, O. (Olivier); Lathrop, G.M. (Mark); Lokki, M.L.; Luben, R.N. (Robert); Ludwig, B. (Barbara); McArdle, W.L. (Wendy); McCcarthy, A. (Anne); Morken, M.A. (Mario); Nelis, M. (Mari); Neville, M.J. (Matthew); Paré, G. (Guillaume); Parker, A.N. (Alex); Peden, J. (John); Pichler, I. (Irene); Pietilainen, K.H. (Kirsi Hannele); Platou, C.P. (Carl); Pouta, A. (Anneli); Ridderstråle, M. (Martin); Samani, N.J. (Nilesh); Saramies, J. (Jouko); Sinisalo, J. (Juha); Smit, J.H. (Jan); Strawbridge, R.J. (Rona); Stringham, H.M. (Heather); Swift, A.J. (Amy); Teder-Llaving, M. (Maris); Thomson, B. (Brian); Usala, G.; Mmeurs, van J.B.J. (Joyce); Ommen, van G.J. (Gert); Vatin, V. (Vincent); Volpato, C.B.; Wallaschofski, H. (Henri); Walters, G.B. (Bragi); Widen, E. (Elisabeth); Wild, S.H. (Sarah); Willemsen, G.A.H.M. (Gonneke); Witte, D.R. (Deniel); Zgaga, L. (Lina); Zitting, P. (Paavo); Beilby, J.P. (John); James, A. (Alan); Kähönen, M. (Mika); Lehtimäki, T. (Terho); Nieminen, M.S. (Markku); Ohlsson, C. (Claes); Palmer, C. (Cameron); Raitakari, O. (Olli); Ridker, P.M. (Paul); Stumvoll, M. (Michael); Tönjes, A. (Anke); Viikari, J. (Jorma); Balkau, B. (Beverley); Ben-Shlomo, Y.; Bergman, R.N. (Richard); Boeing, H.; Smith, A.V. (Albert Vernon); Eebrahim, S. (Shah); Froguel, P. (Philippe); Hansen, T. (Torben); Hengstenberg, C. (Christian); Hveem, K. (Kristian); Isomaa, B. (Bo); Jørgensen, T. (Torben); Karpe, F. (Fredrik); Khaw, K-T. (Kay-Tee); Laakso, M. (Markku); Lawlor, D.A. (Debbie); Marre, M. (Michel); Meitinger, T. (Thomas); Metspalu, A. (Andres); Midthjell, K. (Kristian); Pedersen, O. (Oluf); Salomaa, V. (Veikko); Schwarz, P.E.H. (Peter); Tuomi, T. (Tiinamaija); Tuomilehto, J. (Jaakko); Valle, T.T. (Timo); Wareham, N.J. (Nicholas); Arnold, A.M. (Alice); Beckmann, J.S. (Jacques); Bergmann, S. (Sven); Boerwinkle, E. (Eric); Boomsma, D.I. (Dorret); Caulfield, M. (Mark); Collins, F.S. (Francis); Eeiriksdottir, G. (Gudny); Gudnason, V. (Vilmundur); Gyllensten, U. (Ulf); Hamsten, A. (Anders); Hattersley, A.T. (Andrew); Hofman, A. (Albert); Hu, F.B. (Frank); Illig, T. (Thomas); Iribarren, C. (Carlos); Järvelin, M.R.; Kao, W.H.L. (Wen); Kaprio, J. (Jaakko); Launer, L.J. (Lenore); Munroe, P. (Patricia); Oostra, B.A. (Ben); Penninx, B.W.J.H. (Brenda); Pramstaller, P.P. (Peter Paul); Psaty, B.M. (Bruce); Quertermous, T. (Thomas); Rissanen, A. (Aila); Rudan, I. (Igor); Shuldiner, A.R. (Alan); Soranzo, N. (Nicole); Spector, T.D. (Timothy); Syvanen, A.C.; Uda, M.; Uitterlinden, A.G. (André); Völzke, H. (Henry); Vollenweider, P. (Peter); Wilson, J.F. (James); Witteman, J.C.M. (Jacqueline); Wright, A.F. (Alan); Abecasis, G.R. (Gonçalo); Boehnke, M. (Michael); Borecki, I.B. (Ingrid); Deloukas, P. (Panagiotis); Frayling, T.M. (Timothy); Groop, L. (Leif); Haritunians, T. (Talin); Hunter, D.J. (David); North, K.E. (Kari); O'Cconnell, J.R. (Jeffrey); Peltonen, L. (Leena Johanna); Schlessinger, D.; Strachan, D.P. (David); Hirschhorn, J.N. (Joel); Assimes, T.L. (Themistocles); Wichmann, H.E. (Heinz Erich); Thorsteinsdottir, U. (Unnur); Dduijn, van C. (Cornelia); Stefansson, K. (Kari); Cupples, L.A. (Adrienne); Loos, R.J.F. (Ruth); Barroso, I. (Inês); Fox, C.S. (Caroline); Mohlke, K.L. (Karen); Lindgren, C.M. (Cecilia)
    In:Nature Genetics, 42(11), 949 - 960. ISSN 1061-4036.

    Samenvatting:

    Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR a

  • Hundreds of variants clustered in genomic loci and biological pathways affect human height (2010)

    Auteurs:Allen, H.L.; Estrada Gil, K. (Karol); Lettre, G. (Guillaume); Berndt, S.I. (Sonja); Weedon, M.N. (Michael); Rivadeneira Ramirez, F. (Fernando); Willer, C.J. (Cristen); Jackson, A.U. (Anne); Vedantam, S. (Sailaja); Raychaudhuri, S. (Soumya); Ferreira, T. (Teresa); Wood, A.R. (Andrew); Weyant, R.J. (Robert); Segrè, A.V. (Ayellet); Speliotes, E.K. (Elizabeth); Wheeler, E. (Eleanor); Soranzo, N. (Nicole); Park, J.H.; Yang, J. (Joanna); Gudbjartsson, D.F. (Daniel); Heard-Costa, N.L. (Nancy); Randall, J.C. (Joshua); Qi, L. (Lu); Smith, A.V. (Albert Vernon); Mägi, R. (Reedik); Pastinen, T. (Tomi); Liang, L. (Liming); Heid, I.M. (Iris); Luan, J.; Thorleifsson, G. (Gudmar); Winkler, T. (Thomas); Goddard, M.E. (Michael); Lo, K.S.; Palmer, C. (Cameron); Workalemahu, T. (Tsegaselassie); Aulchenko, Y.S. (Yurii); Johansson, A. (Åsa); Zillikens, M.C. (Carola); Feitosa, M.F. (Mary Furlan); Esko, T. (Tõnu); Johnson, T. (Toby); Ketkar, S. (Shamika); Kraft, P. (Peter); Mangino, M. (Massimo); Prokopenko, I. (Inga); Absher, D. (Devin); Albrecht, E. (Eva); Ernst, F.D.J. (Florian); Glazer, N.L. (Nicole); Hayward, C. (Caroline); Hottenga, J.J.; Jacobs, K.B. (Kevin); Knowles, J.W. (Joshua); Kutalik, Z. (Zoltán); Monda, K.L. (Keri); Polasek, O. (Ozren); Preuss, M. (Michael); Rayner, N.W. (N William); Robertson, N.R. (Neil); Steinthorsdottir, V. (Valgerdur); Tyrer, J.P. (Jonathan); Voight, B.F. (Benjamin); Wiklund, F. (Fredrik); Xu, J. (Jianfeng); Zhao, J.H.; Nyholt, D.R. (Dale); Pellikka, N. (Niina); Perola, M. (Markus); Perry, J.R.B. (John); Surakka, I. (Ida); Tammesoo, M.L.; Altmaier, E.L. (Elizabeth); Amin, N. (Najaf); Aspelund, T. (Thor); Bhangale, T. (Tushar); Boucher, G. (Gabrielle); Chasman, D.I. (Daniel); Chen, C.; Coin, L. (Lachlan); Cooper, M.N. (Matthew); Dixon, A.L. (Anna); Gibson, Q. (Quince); Grundberg, E. (Elin); Hao, K. (Ke); Junttila, M.J. (Juhani); Kaplan, R.; Kettunen, J. (Johannes); König, I.R. (Inke); Kwan, T. (Tony); Lawrence, R.W. (Robert); Levinson, D.F. (Douglas); Lorentzon, M. (Mattias); McKnight, B. (Barbara); Morris, A.D. (Andrew); Müller, M. (Martina); Ngwa, J.S.; Purcell, S. (Shaun); Rafelt, S. (Suzanne); Salem, R.M. (Rany); Salvi, E. (Erika); Sanna, S.; Shi, J. (Jianxin); Sovio, U. (Ulla); Thompson, J.R. (John); Turchin, M.C. (Michael); Vandenput, L. (Liesbeth); Verlaan, D.J. (Dominique); Vitart, V. (Veronique); White, C.C. (Charles); Ziegler, A.; Almgren, P. (Peter); Balmforth, A.J. (Anthony); Campbell, H. (Harry); Citterio, L. (Lorena); Grandi, de A. (Alessandro); Dominiczak, A. (Anna); Duan, J. (Jubao); Elliott, P. (Paul); Elosua, R. (Roberto); Eriksson, J.G. (Johan); Freimer, N.B. (Nelson); Geus, E.J.C. (Eco); Glorioso, N. (Nicola); Haiqing, S. (Shen); Hartikainen, A.L.; Havulinna, A.S. (Aki); Hicks, A.A. (Andrew); Hui, J. (Jennie); Igl, W. (Wilmar); Illig, T. (Thomas); Jula, A. (Antti); Kajantie, E. (Eero); Kilpeläinen, T.O. (Tuomas); Koiranen, M. (Markku); Kolcic, I. (Ivana); Koskinen, S. (Seppo); Kovacs, P. (Peter); Laitinen, J. (Jaana); Liu, J. (Jianjun); Lokki, M.L.; Marusic, A. (Ana); Maschio, A.; Meitinger, T. (Thomas); Mulas, A. (Antonella); Paré, G. (Guillaume); Parker, A.N. (Alex); Peden, J. (John); Petersmann, A. (Astrid); Pichler, I. (Irene); Pietilainen, K.H. (Kirsi Hannele); Pouta, A. (Anneli); Ridderstråle, M. (Martin); Rotter, J.I. (Jerome); Sambrook, J.G. (Jennifer); Sanders, A.R. (Alan); Schmidt, C.O. (Carsten Oliver); Sinisalo, J. (Juha); Smit, J.H. (Jan); Stringham, H.M. (Heather); Walters, G.B. (Bragi); Widen, E. (Elisabeth); Wild, S.H. (Sarah); Willemsen, G.A.H.M. (Gonneke); Zagato, L. (Laura); Zgaga, L. (Lina); Zitting, P. (Paavo); Alavere, H. (Helene); Farrall, M. (Martin); McArdle, W.L. (Wendy); Nelis, M. (Mari); Peters, M.J. (Marjolein); Ripatti, S. (Samuli); Meurs, van J.B.J. (Joyce); Aben, K.K.H. (Katja); Beckmann, J.S. (Jacques); Beilby, J.P. (John); Bergman, R.N. (Richard); Bergmann, S. (Sven); Collins, F.S. (Francis); Cusi, D. (Daniele); Heijer, den M. (Martin); Eiriksdottir, G. (Gudny); Gejman, P.V. (Pablo); Hall, A.S. (Alistair); Hamsten, A. (Anders); Huikuri, H.V. (Heikki); Iribarren, C. (Carlos); Kähönen, M. (Mika); Kaprio, J. (Jaakko); Kathiresan, S. (Sekar); Kiemeney, L.A.L.M. (Bart); Kocher, T. (Thomas); Launer, L.J. (Lenore); Lehtimäki, T. (Terho); Melander, O. (Olle); Mosley, T.H. (Thomas); Musk, A.W. (Arthur); Nieminen, M.S. (Markku); O'Donnell, C.J. (Christopher); Ohlsson, C. (Claes); Oostra, B.A. (Ben); Raitakari, O. (Olli); Ridker, P.M. (Paul); Rioux, J.D. (John); Rissanen, A. (Aila); Rivolta, C. (Carlo); Schunkert, H. (Heribert); Shuldiner, A.R. (Alan); Siscovick, D.S. (David); Stumvoll, M. (Michael); Tönjes, A. (Anke); Tuomilehto, J. (Jaakko); Ommen, van G.J. (Gert); Viikari, J. (Jorma); Heath, A.C. (Andrew); Martin, N.G. (Nicholas); Montgomery, G.W. (Grant); Province, M.A. (Mike); Kayser, M. (Manfred); Arnold, A.M. (Alice); Atwood, L.D. (Larry); Boerwinkle, E. (Eric); Chanock, S.J. (Stephen); Deloukas, P. (Panagiotis); Gieger, C. (Christian); Grönberg, H. (Henrik); Hattersley, A.T. (Andrew); Hengstenberg, C. (Christian); Hoffman, W. (Wolfgang); Lathrop, G.M. (Mark); Salomaa, V. (Veikko); Schreiber, S. (Stefan); Uda, M.; Waterworth, D. (Dawn); Wright, A.F. (Alan); Assimes, T.L. (Themistocles); Barroso, I. (Inês); Hofman, A. (Albert); Mohlke, K.L. (Karen); Boomsma, D.I. (Dorret); Caulfield, M. (Mark); Cupples, L.A. (Adrienne); Erdmann, J. (Jeanette); Fox, C.S. (Caroline); Gudnason, V. (Vilmundur); Gyllensten, U. (Ulf); Harris, T.B. (Tamara); Hayes, R.B. (Richard); Järvelin, M.R.; Mooser, V. (Vincent); Munroe, P. (Patricia); Ouwehand, W.H. (Willem); Penninx, B.W.J.H. (Brenda); Pramstaller, P.P. (Peter Paul); Quertermous, T. (Thomas); Rudan, I. (Igor); Samani, N.J. (Nilesh); Spector, T.D. (Timothy); Völzke, H. (Henry); Watkins, H. (Hugh); Wilson, J.F. (James); Groop, L. (Leif); Haritunians, T. (Talin); Hu, F.B. (Frank); Metspalu, A. (Andres); North, K.E. (Kari); Schlessinger, D.; Wareham, N.J. (Nicholas); Hunter, D.J. (David); O´Connell, J.R.; Strachan, D.P. (David); Wichmann, H.E. (Heinz Erich); Borecki, I.B. (Ingrid); Duijn, van C.M. (Cock); Schadt, E.E. (Eric); Thorsteinsdottir, U. (Unnur); Peltonen, L. (Leena Johanna); Uitterlinden, A.G. (André); Visscher, P.M. (Peter); Chatterjee, N. (Nilanjan); Loos, R.J.F. (Ruth); Boehnke, M. (Michael); McCarthy, M.I. (Mark); Ingelsson, E. (Erik); Lindgren, C.M. (Cecilia); Abecasis, G.R. (Gonçalo); Stefansson, K. (Kari); Frayling, T.M. (Timothy); Hirschhorn, J.N. (Joel); Ardlie, K. (Kristin)
    In:Nature: international weekly journal of science, 467(7317), 832 - 838. ISSN 0028-0836.

    Samenvatting:

    Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits1, but these typically explain small fractions o

  • Mother's educational level and fetal growth: The genesis of health inequalities (2010)

    Auteurs:Silva, L.M. (Lindsay); Jansen, P.W. (Pauline); Steegers-Theunissen, R.P.M. (Regine); Jaddoe, V.W.V. (Vincent); Arends, L.R. (Lidia); Tiemeier, H. (Henning); Verhulst, F.C. (Frank); Moll, H.A. (Henriëtte); Hofman, A. (Albert); Mackenbach, J.P. (Johan); Raat, H. (Hein)
    In:International Journal of Epidemiology, 39(5), 1250 - 1261. ISSN 0300-5771.

    Samenvatting:

    Background: Women of low socio-economic status (SES) give birth to lighter babies. It is unknown from which moment during pregnancy socio-economic differences in fetal weight can be observed, whether low SES equally affects different fetal-growth components, or what the effect of low SES is after ta

  • An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility loci for osteoporosis-related traits (2010)Open access

    Auteurs:Hsu, C.Y. (Chao); Zillikens, M.C. (Carola); Wilson, S.G. (Scott); Farber, C.R. (Charles); Demissie, S. (Serkalem); Soranzo, N. (Nicole); Bianchi, E.N. (Estelle); Grundberg, E. (Elin); Liang, L. (Liming); Richards, J.B. (Brent); Estrada, K. (Karol); Zhou, Y. (Yanhua); Nas, van A. (Atila); Moffatt, M.F. (Miriam); Zhai, G. (Guangju); Hofman, A. (Albert); Meurs, van J.B.J. (Joyce); Pols, H.A.P. (Huibert); Price, R.I. (Roger Ian); Nilsson, O. (Ola); Pastinen, T. (Tomi); Cupples, L.A. (Adrienne); Lusis, A.J. (Aldons Jake); Schadt, E.E. (Eric); Ferrari, S. (Serge); Uitterlinden, A.G. (André); Rivadeneira Ramirez, F. (Fernando); Spector, T.D. (Timothy); Karasik, D. (David); Kiel, D.P. (Douglas)
    In:P L o S Genetics (Print), 6(6), 1 - 16. ISSN 1553-7390.

    Samenvatting:

    Osteoporosis is a complex disorder and commonly leads to fractures in elderly persons. Genome-wide association studies (GWAS) have become an unbiased approach to identify variations in the genome that potentially affect health. However, the genetic variants identified so far only explain a small pro

  • Early detection and counselling intervention of asthma symptoms in preschool children: Study design of a cluster randomised controlled trial (2010)Open access

    Auteurs:Hafkamp-De Groen, E.H.D. (Esther); Mohangoo, A.D. (Ashna); Jongste, de J.C. (Johan); Wouden, van der J.C. (Hans); Moll, H.A. (Henriëtte); Jaddoe, V.W.V. (Vincent); Hofman, A. (Albert); Koning, de H.J. (Harry); Raat, H. (Hein)
    In:BMC Public Health, 10. ISSN 1471-2458.

    Samenvatting:

    Background. Prevention of childhood asthma is an important public health objective. This study evaluates the effectiveness of early detection of preschool children with asthma symptoms, followed by a counselling intervention at preventive child health centres. Early detection and counselling is expe

  • Digital quantification of human eye color highlights genetic association of three new loci. (2010)Open access

    Auteurs:Liu, F. (Fan); Wollstein, A. (Andreas); Hysi, P.G. (Pirro); Ankra-Badu, G.A. (Georgina); Spector, T.D. (Timothy); Park, D. (Daniel); Zhu, G.; Larsson, M. (Mats); Duffy, D.L. (David); Montgomery, G.W. (Grant); Mackey, D.A. (David); Walsh, S. (Susan); Lao, O. (Oscar); Hofman, A. (Albert); Rivadeneira Ramirez, F. (Fernando); Vingerling, J.R. (Hans); Uitterlinden, A.G. (André); Martin, N.G. (Nicholas); Hammond, C.J. (Christopher); Kayser, M. (Manfred)
    In:PL o S Genetics (Online), 6. ISSN 1553-7404.

    Samenvatting:

    Previous studies have successfully identified genetic variants in several genes associated with human iris (eye) color; however, they all used simplified categorical trait information. Here, we quantified continuous eye color variation into hue and saturation values using high-resolution digital ful

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