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Prof.dr. A. Hofman Persoon

Prof.dr. A. Hofman

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  • Cataract surgery and the risk of aging macula disorder: The Rotterdam study (2008)

    Auteurs:Ho, L. (Lintje); Boekhoorn, S. (Sharmila); Liana, ; Tikka-Kleemola, P. (Päivi); Uitterlinden, A.G. (André); Hofman, A. (Albert); Jong, de P.T.V.M. (Paulus); Stijnen, Th. (Theo); Vingerling, J.R. (Hans)
    In:Investigative Ophthalmology & Visual Science, 49(11), 4795 - 4800. ISSN 0146-0404.

    Samenvatting:

    PURPOSE. To investigate still-controversial associations between prior cataract surgery and aging macula disorder (AMD) in a general population. METHODS. Baseline lens status and risk of incident AMD (iAMD) were examined in participants of the prospective population-based Rotterdam Study at risk for

  • What is spared by fetal brain-sparing? Fetal circulatory redistribution and behavioral problems in the general population (2008)Open access

    Auteurs:Roza, S.J. (Sabine); Steegers, E.A.P. (Eric); Verburg, B.O. (Bero Olof); Jaddoe, V.W.V. (Vincent); Moll, H.A. (Henriëtte); Hofman, A. (Albert); Verhulst, F.C. (Frank); Tiemeier, H. (Henning)
    In:American Journal of Epidemiology, 168(10), 1145 - 1152. ISSN 0002-9262.

    Samenvatting:

    Intrauterine growth restriction has been linked to infant behavioral problems. While typically only birth weight is examined, here the authors assessed fetal circulatory redistribution, also called the "brain-sparing effect," which is a fetal adaptive reaction to placental insufficiency. They aimed

  • Lack of association of two common polymorphisms on 9p21 with risk of coronary heart disease and myocardial infarction; results from a prospective cohort study (2008)Open access

    Auteurs:Dehghan, A. (Abbas); Hoek, van M. (Mandy); Sijbrands, E.J.G. (Eric); Oostra, B.A. (Ben); Hofman, A. (Albert); Tikka-Kleemola, P. (Päivi); Witteman, J.C.M. (Jacqueline)
    In:BMC Medicine, 6. ISSN 1741-7015.

    Samenvatting:

    Background: Recent genome wide association (GWA) studies identified two Single Nucleotide Polymorphisms (SNP) (rs10757278 and rs10757274) in the region of the CDK2NA and CDK2NB genes to be consistently associated with the risks of coronary heart disease (CHD) and myocardial infarction (MI). We exami

  • Orthostatic hypotension and risk of cardiovascular disease in elderly people: The Rotterdam study (2008)Open access

    Auteurs:Verwoert, G.C. (Germaine); Mattace Raso, F.U.S. (Francesco); Heeringa, J. (Jan); Stricker, B.H.Ch. (Bruno); Breteler, M.M.B. (Monique); Witteman, J.C.M. (Jacqueline); Hofman, A. (Albert)
    In:American Geriatrics Society. Journal, 56(10), 1816 - 1820. ISSN 0002-8614.

    Samenvatting:

    OBJECTIVES: To determine the prognostic role of orthostatic hypotension for cardiovascular disease (CVD) and all-cause mortality in elderly people. DESIGN: Prospective study. SETTING: Community based. PARTICIPANTS: Five thousand sixty-four subjects from the Rotterdam study aged 55 and older. MEASURE

  • Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study (2008)

    Auteurs:Dehghan, A. (Abbas); Köttgen, A. (Anna); Yang, Q. (Qiong Fang); Hwang, S.J.; Kao, W.H.L. (Wen); Rivadeneira Ramirez, F. (Fernando); Boerwinkle, E. (Eric); Levy, D. (Daniel); Hofman, A. (Albert); Astor, B.C. (Brad); Benjamin, E.J. (Emelia); Tikka-Kleemola, P. (Päivi); Witteman, J.C.M. (Jacqueline); Coresh, J. (Josef); Fox, C.S. (Caroline)
    In:The Lancet, 372(9654), 1953 - 1961. ISSN 0140-6736.

    Samenvatting:

    Background: Hyperuricaemia, a highly heritable trait, is a key risk factor for gout. We aimed to identify novel genes associated with serum uric acid concentration and gout. Methods: Genome-wide association studies were done for serum uric acid in 7699 participants in the Framingham cohort and in 41

  • Salivary cortisol is related to atherosclerosis of carotid arteries (2008)

    Auteurs:Dekker, M.J.H.J. (Marieke); Koper, J.W. (Jan); Aken, van M.O. (Maarten); Pols, H.A.P. (Huib); Hofman, A. (Albert); Jong, de F.H. (Frank); Kirschbaum, C. (Clemens); Witteman, J.C.M. (Jacqueline); Lamberts, S.W.J. (Steven); Tiemeier, H. (Henning)
    In:Journal of Clinical Endocrinology and Metabolism, 93(10), 3741 - 3747. ISSN 0021-972x.

    Samenvatting:

    Background: Dysregulation of the hypothalamic-pituitary-adrenal axis has been suggested as an independent risk factor for ischemic heart disease. The aim of our study was to evaluate whether two markers of the hypothalamic-pituitary- adrenal axis activity, the level of salivary cortisol and the diur

  • Disagreement between subjective and actigraphic measures of sleep duration in a population-based study of elderly persons (2008)

    Auteurs:Berg, van den J.F. (Julia); Rooij, van F.J.A. (Frank); Vos, H.; Tulen, J.H.M. (Joke); Hofman, A. (Albert); Miedema, H.M. (Henk); Neven, A.K.; Tiemeier, H. (Henning)
    In:Journal of Sleep Research (Print), 17(3), 295 - 302. ISSN 0962-1105.

    Samenvatting:

    Sleep duration is an important concept in epidemiological studies. It characterizes a night's sleep or a person's sleep pattern, and is associated with numerous health outcomes. In most large studies, sleep duration is assessed with questionnaires or sleep diaries. As an alternative, actigraphy may

  • A variant of the IGF-I gene is associated with blood pressure but not with left heart dimensions at the age of 2 years: The Generation R Study (2008)

    Auteurs:Houten, van V.A.A. (Vera); Mook-Kanamori, D.O. (Dennis); Osch-Gevers, van L. (Lennie); Steegers-Theunissen, R.P.M. (Regine); Hofman, A. (Albert); Moll, H.A. (Henriëtte); Tikka-Kleemola, P. (Päivi); Helbing, W.A. (Willem); Hokken-Koelega, A.C.S. (Anita); Jaddoe, V.W.V. (Vincent)
    In:European Journal of Endocrinology, 159(3), 209 - 216. ISSN 0804-4643.

    Samenvatting:

    Background and objective: A common variant of the IGF-I gene has been shown to be associated with cardiovascular disease in adulthood. The objective of this study was to examine whether this variant of the IGF-I gene is associated with blood pressure and left heart dimensions in early childhood. Res

  • Smoke exposure, airway symptoms and exhaled nitric oxide in infants: The Generation R study (2008)

    Auteurs:Gabriele, C. (Carmelo); Asgarali, R.; Jaddoe, V.W.V. (Vincent); Hofman, A. (Albert); Moll, H.A. (Henriëtte); Jongste, de J.C. (Johan)
    In:The European Respiratory Journal, 32(2), 307 - 313. ISSN 0903-1936.

    Samenvatting:

    The effect of pre- and post-natal smoke exposure on exhaled nitric oxide fraction (FeNO) in infants was evaluated and the association between respiratory symptoms and FeNO in the first 2 months of life was investigated. The Generation R study is a population-based, prenatally recruited birth cohort.

  • An RBP4 promoter polymorphism increases risk of type 2 diabetes (2008)Open access

    Auteurs:Hoek, van M. (Mandy); Dehghan, A. (Abbas); Zillikens, M.C. (Carola); Hofman, A. (Albert); Witteman, J.C.M. (Jacqueline); Sijbrands, E.J.G. (Eric)
    In:Diabetologia: clinical and experimental diabetes and metabolism, 51(8), 1423 - 1428. ISSN 0012-186x.

    Samenvatting:

    Aims/hypothesis: Retinol-binding protein 4 (RBP4), originally known for retinol transport, was recently identified as an adipokine affecting insulin resistance. The RBP4 -803GA promoter polymorphism influences binding of hepatic nuclear factor 1α and is associated with type 2 diabetes in case-contro

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