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Prof.dr. A. Hofman Persoon

Prof.dr. A. Hofman

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  • Serum cholesterol levels and the risk of Parkinson's disease (2006)Open access

    Auteurs:Lau, de L.M.L. (Lonneke); Koudstaal, P.J. (Peter); Hofman, A. (Albert); Breteler, M.M.B. (Monique)
    In:American Journal of Epidemiology, 164(10), 998 - 1002. ISSN 0002-9262.

    Samenvatting:

    Several recent findings suggest a role of lipid and cholesterol metabolism in the pathogenesis of Parkinson's disease. Therefore, the authors examined the association between serum levels of cholesterol and the risk of Parkinson's disease in the prospective, population-based Rotterdam Study among 6,

  • Insulin-like growth factor I promoter polymorphism, risk of stroke, and survival after stroke: the Rotterdam study (2006)Open access

    Auteurs:Rijn, van M.J.E. (Marie Josee); Slooter, A.J.C. (Arjen); Bos, M.J. (Michiel); Catarino, C.F.B.S.; Koudstaal, P.J. (Peter); Hofman, A. (Albert); Breteler, M.M.B. (Monique); Duijn, van C.M. (Cock)
    In:Journal of Neurology, Neurosurgery and Psychiatry: an international peer-reviewed journal for health professionals and researchers in all areas of neurology and neurosurgery, 77(1), 24 - 27. ISSN 0022-3050.

    Samenvatting:

    BACKGROUND AND PURPOSE: Low levels of insulin-like growth factor I (IGF-I) predispose to atherosclerosis and may therefore increase the risk of stroke. Low levels have also been found to influence the outcome of cardiovascular and cerebrovascular disease. A polymorphism in the promoter region of the

  • Retinal vessel diameters and risk of impaired fasting glucose or diabetes: the Rotterdam study (2006)Open access

    Auteurs:Ikram, M.K. (Kamran); Roos, A.M.; Rietveld, I. (Ingrid); Witteman, J.C.M. (Jacqueline); Breteler, M.M.B. (Monique); Duijn, van C.M. (Cock); Jong, de P.T.V.M. (Paulus); Janssen, J.A.M.J.L. (Joop); Hofman, A. (Albert)
    In:Diabetes, 506 - 510. ISSN 0012-1797.

    Samenvatting:

    The association between a smaller retinal arteriolar-to-venular ratio (AVR) and incident diabetes may be due to arteriolar narrowing, venular dilatation, or both. We investigated associations between baseline vessel diameters and incident impaired fasting glucose or diabetes in a population-based co

  • Cerebral small-vessel disease and decline in information processing speed, executive function and memory (2005)Open access

    Auteurs:Prins, N.D. (Niels); Dijk, van E.J. (Ewoud); Heijer, den T. (Tom); Vermeer, S.E. (Sarah); Jolles, J. (Jellemer); Koudstaal, P.J. (Peter); Hofman, A. (Albert); Breteler, M.M.B. (Monique)
    In:Brain: a journal of neurology, 128(9), 2034 - 2041. ISSN 0006-8950.

    Samenvatting:

    Cerebral small-vessel disease is common in older people and may contribute to the development of dementia. The objective of the present study was to evaluate the relationship between measures of cerebral small-vessel disease on MRI and the rate of decline in specific cognitive domains in participant

  • Promoter and 3'-untranslated-region haplotypes in the vitamin d receptor gene predispose to osteoporotic fracture: the rotterdam study (2005)Open access

    Auteurs:Fang, Y. (Yue); Uitterlinden, A.G. (André); Meurs, van J.B.J. (Joyce); Alesio, d' A.; Jhamai, M. (Mila); Zhao, H.; Rivadeneira Ramirez, F. (Fernando); Jehan, F.; Pols, H.A.P. (Huibert); Leeuwen, van J.P.T.M. (Hans); Hofman, A. (Albert)
    In:American Journal of Human Genetics. ISSN 0002-9297.

    Samenvatting:

    Polymorphisms of the vitamin D receptor gene (VDR) have been shown to be associated with several complex diseases, including osteoporosis, but the mechanisms are unknown and study results have been inconsistent. We therefore determined sequence variation across the major relevant p

  • A promoter polymorphism of the insulin-like growth factor-I gene is associated with left ventricular hypertrophy (2005)Open access

    Auteurs:Bleumink, G.S. (Gysèle); Schut, A.F.C. (Anna); Sturkenboom, M.C.J.M. (Miriam); Janssen, J.A.M.J.L. (Joop); Witteman, J.C.M. (Jacqueline); Duijn, van C.M. (Cock); Stricker, B.H.Ch. (Bruno); Hofman, A. (Albert)
    In:Heart, 91(2), 239 - 240. ISSN 1355-6037.

  • Variations in estrogen receptor ? gene and risk of dementia, and brain volumes on MRI. (2004)Open access

    Auteurs:Schuit, S.C.E. (Stephanie); Hofman, A. (Albert); Koudstaal, P.J. (Peter); Duijn, van C.M. (Cock); Uitterlinden, A.G. (André); Pols, H.A.P. (Huibert); Breteler, M.M.B. (Monique); Meurs, van J.B.J. (Joyce); Heijer, den T. (Tom)
    In:Molecular Psychiatry, 9(12), 1129 - 1135. ISSN 1359-4184.

    Samenvatting:

    The role of estrogens in Alzheimer's disease (AD) is controversial. We investigated the association between well-recognized, and potentially functional, polymorphisms in the estrogen receptor (ER) gene and the risk of AD in a prospective study of 6056 Caucasian older men and women aged 55 years and

  • Arterial oxygen saturation, COPD, and cerebral small vessel disease (2004)Open access

    Auteurs:Dijk, van E.J. (Ewoud); Vermeer, S.E. (Sarah); Groot, de J.C. (Jan Cees); Minkelis, van de J.; Prins, N.D. (Niels); Oudkerk, M. (Matthijs); Hofman, A. (Albert); Koudstaal, P.J. (Peter); Breteler, M.M.B. (Monique)
    In:Journal of Neurology, Neurosurgery and Psychiatry: an international peer-reviewed journal for health professionals and researchers in all areas of neurology and neurosurgery, 75(5), 733 - 736. ISSN 0022-3050.

    Samenvatting:

    OBJECTIVE: To study whether lower arterial oxygen saturation (SaO(2)) and chronic obstructive pulmonary disease (COPD) are associated with cerebral white matter lesions and lacunar infarcts. METHODS: We measured SaO(2) twice with a pulse oximeter, assessed the presence of COPD, and performed MRI in

  • Interaction between hypertension, apoE, and cerebral white matter lesions. (2004)Open access

    Auteurs:Leeuw, de H.F. (Frank); Richard, F. (Florence); Groot, de J.C. (Jan Cees); Duijn, van C.M. (Cock); Hofman, A. (Albert); Gijn, van J. (Jan); Breteler, M.M.B. (Monique)
    In:Stroke, 35(5), 1057 - 1060. ISSN 0039-2499.

    Samenvatting:

    BACKGROUND AND PURPOSE: Cerebral white matter lesions (WMLs) are frequently found on magnetic resonance imaging scans in both cognitively intact and demented elderly persons. Vascular risk factors, especially hypertension, are related to their presence. However, not every person with vascular risk f

  • Polymorphisms in the prion protein gene and in the doppel gene increase susceptibility for Creutzfeldt-Jakob disease (2004)Open access

    Auteurs:Croes, E.A. (Esther); Alizadeh, B.Z. (Behrooz); Bertoli Avella, A.M. (Aida); Rademaker, T.A.M. (Tessa); Vergeer-Drop, J. (Jeannette); Dermaut, B. (Bart); Houwing-Duistermaat, J.J. (Jeanine); Wientjens, D.P.W.M. (Dorothee); Hofman, A. (Albert); Broeckhoven, van C. (Christine); Duijn, van C.M. (Cock)
    In:European Journal of Human Genetics, 12(5), 389 - 394. ISSN 1018-4813.

    Samenvatting:

    The prion protein gene (PRNP) plays a central role in the origin of Creutzfeldt-Jakob disease (CJD), but there is growing interest in other polymorphisms that may be involved in CJD. Polymorphisms upstream of PRNP that may modulate the prion protein production as well as polymorphisms in the prion-l

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