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Prof.dr. A. Hofman Persoon

Prof.dr. A. Hofman

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  • Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight (2010)

    Auteurs:Freathy, R.M. (Rachel); Mook-Kanamori, D.O. (Dennis); Sovio, U. (Ulla); Prokopenko, I. (Inga); Timpson, N. (Nicholas); Berry, D. (Diane); Warrington, N.; Widen, E. (Elisabeth); Hottenga, J.J.; Kaakinen, M. (Marika); Lange, L.A. (Leslie); Bradfield, J.P. (Jonathan); Kerkhof, M. (Marjan); Marsh, J.A. (Julie); Mägi, R. (Reedik); Chen, C.; Lyon, H.N. (Helen); Kirin, M. (Mirna); Adair, L.S. (Linda); Aulchenko, Y.S. (Yurii); Bennett, A.J. (Amanda); Borja, J.B. (Judith); Bouatia-Naji, N. (Nabila); Charoen, P. (Pimphen); Coin, L. (Lachlan); Cousminer, D.L. (Diana); Geus, de E.J.C. (Eco); Deloukas, P. (Panagiotis); Elliott, P. (Paul); Evans, D.M. (David); Froguel, P. (Philippe); Glaser, B. (Beate); Groves, C.J. (Christopher); Hartikainen, A.L.; Hassanali, N. (Neelam); Hirschhorn, J.N. (Joel); Hofman, A. (Albert); Holly, J.M.P. (Jeff); Hyppönen, E. (Elina); Kanoni, S. (Stavroula); Knight, B.A. (Bridget); Laitinen, J. (Jaana); Lindgren, C.M. (Cecilia); McArdle, W.L. (Wendy); O'Reilly, P.F. (Paul); Pennell, C.E. (Craig); Postma, D.S. (Dirkje); Pouta, A. (Anneli); Ramasamy, A. (Adaikalavan); Rayner, N.W. (N William); Ring, S.M. (Susan); Rivadeneira Ramirez, F. (Fernando); Shields, B.M. (Beverley); Strachan, D.P. (David); Surakka, I. (Ida); Taanila, A. (Anja); Tiesler, C. (Carla); Uitterlinden, A.G. (André); Tikka-Kleemola, P. (Päivi); Wijga, A. (Alet); Willemsen, G.A.H.M. (Gonneke); Zhang, H. (Haitao); Zhao, J.H.; Wilson, J.F. (James); Steegers-Theunissen, R.P.M. (Regine); Hattersley, A.T. (Andrew); Hagen, K. (Knut); Peltonen, L. (Leena Johanna); Mohlke, K.L. (Karen); Grant, S.F.; Hakonarson, H. (Hakon); Koppelman, G.H. (Gerard); Dedoussis, G.V. (George); Heinrich, J. (Joachim); Gillman, M.W. (Matthew W.); Palmer, C. (Cameron); Frayling, T.M. (Timothy); Boomsma, D.I. (Dorret); Smith, G.D.; Power, C. (Christopher); Jaddoe, V.W.V. (Vincent); Jarvelin, M.R.; McCarthy, M.I. (Mark)
    In:Nature Genetics, 42(5), 430 - 435. ISSN 1061-4036.

    Samenvatting:

    To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591). rs900400 near LEKR1 and CCNL1 (P = 2 × 10 35) and rs98832

  • Genome-wide meta-analyses identify multiple loci associated with smoking behavior (2010)

    Auteurs:Furberg, H. (Helena); Kim, Y. (Yunjung); Dackor, J. (Jennifer); Boerwinkle, E. (Eric); Franceschini, N. (Nora); Ardissino, D. (Diego); Bernardinelli, L. (Luisa); Mannucci, P.M. (Pier); Mauri, F. (Francesco); Merlini, P.A. (Piera); Absher, D. (Devin); Assimes, T.L. (Themistocles); Fortmann, S.P. (Stephen); Iribarren, C. (Carlos); Knowles, J.W. (Joshua); Quertermous, T. (Thomas); Ferrucci, L. (Luigi); Tanaka, T. (Toshiko); Bis, J.C. (Joshua); Haritunians, T. (Talin); McKnight, B. (Barbara); Psaty, B.M. (Bruce); Taylor, K.D. (Kent); Thacker, E.L. (Evan); Almgren, P. (Peter); Groop, L. (Leif); Ladenvall, C. (Claes); Boehnke, M. (Michael); Jackson, A.U. (Anne); Mohlke, K.L. (Karen); Stringham, H.M. (Heather); Tuomilehto, J. (Jaakko); Benjamin, E.J. (Emelia); Hwang, S.J.; Levy, D. (Daniel); Preis, S.R.; Vasan, R.S. (Ramachandran Srini); Duan, J. (Jubao); Gejman, P.V. (Pablo); Levinson, D.F. (Douglas); Sanders, A.R. (Alan); Shi, J. (Jianxin); Lips, E.H. (Esther); McKay, J.D. (James); Agudo, A. (Antonio); Barzan, L. (Luigi); Bencko, V. (Vladimir); Benhamou, S. (Simone); Castellsagué, X. (Xavier); Canova, C. (Cristina); Conway, D.I. (David); Fabianova, E. (Eleonora); Foretova, L. (Lenka); Janout, V. (Vladimir); Healy, C.M. (Claire); Holcátová, I. (Ivana); Kjaerheim, K. (Kristina); Lagiou, P.; Lissowska, J. (Jolanta); Lowry, R. (Ray); MacFarlane, T.V. (Tatiana); Mates, D. (Dana); Richiardi, L. (Lorenzo); Rudnai, P. (Peter); Szeszenia-Dabrowska, N. (Neonilia); Zaridze, D.; Znaor, A. (Ariana); Lathrop, M. (Mark); Brennan, P. (Paul); Bandinelli, S. (Stefania); Frayling, T.M. (Timothy); Guralnik, J.M. (Jack); Milaneschi, Y. (Yuri); Perry, J.R.B. (John); Altshuler, D. (David); Elosua, R. (Roberto); Kathiresan, S. (Sekar); Lucas, G. (Gavin); Melander, O. (Olle); Salomaa, V. (Veikko); Schwartz, S.M. (Stephen); Voight, B.F. (Benjamin); Penninx, B.W.J.H. (Brenda); Smit, J.H. (Johannes); Vogelzangs, N. (Nicole); Boomsma, D.I. (Dorret); Geus, de E.J.C. (Eco); Vink, J.M. (Jacqueline); Willemsen, G.A.H.M. (Gonneke); Chanock, S.J. (Stephen); Gu, F. (Fangyi); Hankinson, S.E. (Susan); Hunter, D. (David); Hofman, A. (Albert); Tiemeier, H. (Henning); Uitterlinden, A.G. (André); Tikka-Kleemola, P. (Päivi); Walter, S. (Stefan); Chasman, D.I. (Daniel); Everett, B.M. (Brendan); Pare, G. (Guillaume); Ridker, P.M. (Paul); Li, M.D. (Ming); Maes, H.H. (Hermine); Audrain-Mcgovern, J. (Janet); Posthuma, D. (Danielle); Thornton, L.M. (Laura); Lerman, C. (Caryn); Kaprio, J. (Jaakko); Rose, J.E. (Jed); Ioannidis, J.P.A. (John); Kraft, P. (Peter); Lin, D.Y. (Dan); Sullivan, P.F. (Patrick); O'Donnell, C.J. (Christopher)
    In:Nature Genetics, 42(5), 441 - 447. ISSN 1061-4036.

    Samenvatting:

    Consistent but indirect evidence has implicated genetic factors in smoking behavior. We report meta-analyses of several smoking phenotypes within cohorts of the Tobacco and Genetics Consortium (n = 74,053). We also partnered with the European Network of Genetic and Genomic Epidemiology (ENGAGE) and

  • A 10-year follow-up of hippocampal volume on magnetic resonance imaging in early dementia and cognitive decline (2010)

    Auteurs:Heijer, den T. (Tom); Lijn, van der F. (Fedde); Koudstaal, P.J. (Peter); Hofman, A. (Albert); Lugt, van der A. (Aad); Krestin, G.P. (Gabriel); Niessen, W.J. (Wiro); Breteler, M.M.B. (Monique)
    In:Brain: a journal of neurology, 133(4), 1163 - 1172. ISSN 0006-8950.

    Samenvatting:

    Hippocampal atrophy is frequently observed on magnetic resonance images from patients with Alzheimer's disease and persons with mild cognitive impairment. Even in asymptomatic elderly, a small hippocampal volume on magnetic resonance imaging is a risk factor for developing Alzheimer's disease. Howev

  • Maternal psychological distress and fetal growth trajectories: the Generation R Study (2010)Open access

    Auteurs:Henrichs, J. (Jens); Schenk, J.J. (Jacqueline); Roza, S.J. (Sabine); Lambregtse-van den Berg, M.P. (Mijke); Schmidt, H.G. (Henk); Steegers, E.A.P. (Eric); Hofman, A. (Albert); Jaddoe, V.W.V. (Vincent); Verhulst, F.C. (Frank); Tiemeier, H. (Henning)
    In:Psychological Medicine, 40(4), 633 - 643. ISSN 0033-2917.

    Samenvatting:

    Abstract BACKGROUND: Previous research suggests, though not consistently, that maternal psychological distress during pregnancy leads to adverse birth outcomes. We investigated whether maternal psychological distress affects fetal growth during the period of mid-pregnancy until birth. METHOD: Preg

  • Glucocorticoid receptor gene polymorphisms do not affect growth in fetal and early postnatal life. The Generation R Study (2010)Open access

    Auteurs:Geelhoed, M.J.J. (Miranda); Steegers-Theunissen, R.P.M. (Regine); Koper, J.W. (Jan); Rossum, van E.F.C. (Liesbeth); Moll, H.A. (Henriëtte); Raat, H. (Hein); Tiemeier, H. (Henning); Hofman, A. (Albert); Jaddoe, V.W.V. (Vincent)
    In:B M C Medical Genetics, 11(1). ISSN 1471-2350.

    Samenvatting:

    Background: Glucocorticoids have an important role in early growth and development. Glucocorticoid receptor gene polymorphisms have been identified that contribute to the variability in glucocorticoid sensitivity. We examined whether these glucocorticoid receptor gene polymorphisms are associated wi

  • Correlation of bacterial colonization status between mother and child: The generation R study (2010)

    Auteurs:Lebon, A. (Ankie); Moll, H.A. (Henriëtte); Tavakol, M. (Mehri); Wamel, van W.J.B. (Willem); Jaddoe, V.W.V. (Vincent); Hofman, A. (Albert); Verbrugh, H.A. (Henri); Belkum, van A.F. (Alex)
    In:Journal of Clinical Microbiology, 48(3), 960 - 962. ISSN 0095-1137.

    Samenvatting:

    Determinants of bacterial colonization in children have been described. In the Generation R Study, a population-based cohort study, we determined whether the colonization statuses of mothers and children are correlated. Such a correlation was observed for Staphylococcus aureus and Haemophilus influe

  • Common variants in KCNN3 are associated with lone atrial fibrillation (2010)

    Auteurs:Ellinor, P.T. (Patrick); Lunetta, K.L. (Kathryn); Glazer, N.L. (Nicole); Pfeufer, A. (Arne); Alonso, A. (Alvaro); Chung, M.K. (Mina); Sinner, M.F. (Moritz); Bakker, de P.I.W. (Paul); Mueller, M. (Martina); Lubitz, S.A. (Steven); Fox, E.R. (Ervin); Darbar, D. (Dawood); Smith, N.L. (Nicholas); Schnabel, R. (Renate); Soliman, E.Z. (Elsayed); Rice, K. (Kenneth); Wagoner, van D.R. (David); Beckmann, B.M. (Britt); Noord, van C. (Charlotte); Wang, T.J. (Thomas); Ehret, G.B. (Georg); Rotter, J.I. (Jerome); Hazen, S.L. (Stanley); Steinbeck, G. (Gerhard); Launer, L.J. (Lenore); Harris, T.B. (Tamara); Makino, S. (Seiko); Nelis, M. (Mari); Milan, D.J. (David); Perz, S. (Siegfried); Esko, T. (Tõnu); Köttgen, A. (Anna); Moebus, S. (Susanne); Newton-Cheh, C. (Christopher); Li, M. (Man); Möhlenkamp, S. (Stefan); Linda Kao, W.H.; Vasan, R.S. (Ramachandran Srini); Nöthen, M.M. (Markus); MacRae, C.A. (Calum); Stricker, B.H.Ch. (Bruno); Hofman, A. (Albert); Uitterlinden, A.G. (André); Levy, D. (Daniel); Boerwinkle, E. (Eric); Metspalu, A. (Andres); Topol, E.J. (Eric); Chakravarti, A. (Aravinda); Gudnason, V. (Vilmundur); Psaty, B.M. (Bruce); Roden, D.M. (Dan); Meitinger, T. (Thomas); Wichmann, H.E. (Erich); Witteman, J.C.M. (Jacqueline); Barnard, J. (John); Arking, D.E. (Dan); Benjamin, E.J. (Emelia); Heckbert, S.R. (Susan); Kääb, S. (Stefan)
    In:Nature Genetics, 42(3), 240 - 244. ISSN 1061-4036.

    Samenvatting:

    Atrial fibrillation (AF) is the most common sustained arrhythmia. Previous studies have identified several genetic loci associated with typical AF. We sought to identify common genetic variants underlying lone AF. This condition affects a subset of individuals without overt heart disease and with an

  • Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels (2010)

    Auteurs:Barbalic, M. (maja); Dupuis, J. (Josée); Dehghan, A. (Abbas); Bis, J.C. (Joshua); Hoogeveen, R.C. (Ron); Schnabel, R. (Renate); Nambi, V. (Vijay); Bretler, M. (Monique); Smith, N.L. (Nicholas); Peters, A. (Annette); Lu, C. (Chao); Tracy, R.P. (Russell); Aleksic, N. (Nena); Heeriga, J. (Jan); Keaney, J.F. (John); Rice, K. (Kenneth); Lip, G.Y. (Gregory); Vasan, R.S. (Ramachandran Srini); Glazer, N.L. (Nicole); Larson, M.G. (Martin); Uitterlinden, A.G. (André); Yamamoto, J.F. (Jennifer); Durda, P. (Peter); Haritunians, T. (Talin); Psaty, B.M. (Bruce); Boerwinkle, E. (Eric); Hofman, A. (Albert); Koenig, W. (Wolfgang); Jenny, N.S. (Nancy); Witteman, J.C.M. (Jacqueline); Ballantyne, C. (Christie); Benjamin, E.J. (Emelia)
    In:Human Molecular Genetics, 19(9), 1863 - 1872. ISSN 0964-6906.

    Samenvatting:

    P-selectin and intercellular adhesion molecule-1 (ICAM-1) participate in inflammatory processes by promoting adhesion of leukocytes to vascular wall endothelium. Their soluble levels have been associated with adverse cardiovascular events. To identify loci affecting soluble levels of P-selectin (sP-

  • Risk factors and outcomes associated with first-trimester fetal growth restriction (2010)Open access

    Auteurs:Mook-Kanamori, D.O. (Dennis); Steegers, E.A.P. (Eric); Eilers, P.H. (Paul); Raat, H. (Hein); Hofman, A. (Albert); Jaddoe, V.W.V. (Vincent)
    In:J A M A: The Journal of the American Medical Association, 303(6), 527 - 534. ISSN 0098-7484.

    Samenvatting:

    Context: Adverse environmental exposures lead to developmental adaptations in fetal life. The influences of maternal physical characteristics and lifestyle habits on first-trimester fetal adaptations and the postnatal consequences are not known. Objective: To determine the risk factors and outcomes

  • Genome-wide association studies of mri-defined brain infarcts: Meta-analysis from the charge consortium (2010)Open access

    Auteurs:Debette, S. (Stéphanie); Bis, J.C. (Joshua); Fornage, M. (Myriam); Schmid, H.A. (Herbert); Ikram, M.A. (Mohammed Arfan); Sigurdsson, S. (Stefan); Heiss, G. (Gerardo); Struchalin, M.V. (Maksim); Smith, A.V. (Albert Vernon); Lugt, van der A. (Aad); DeCarli, C. (Charles); Lumley, T. (Thomas); Knopman, D.S. (David); Enzinger, C. (Christian); Eiriksdottir, G. (Gudny); Koudstaal, P.J. (Peter); DeStefano, A.L. (Anita); Psaty, B.M. (Bruce); Dufouil, C. (Carole); Catellier, D.J. (Diane); Fazekas, F. (Franz); Aspelund, T. (Thor); Aulchenko, Y.S. (Yurii); Beiser, A. (Alexa); Rotter, J.I. (Jerome); Tzourio, C. (Christophe); Shibata, D.K. (Dean); Tscherner, M. (Maria); Harris, T.B. (Tamara); Rivadeneira Ramirez, F. (Fernando); Atwood, L.D. (Larry); Rice, K. (Kenneth); Gottesman, R.F. (Rebecca); Buchem, van M.A. (Mark); Uitterlinden, A.G. (André); Kelly-Hayes, M. (Margaret); Cushman, M. (Mary Ann); Zhu, Y. (Yicheng); Boerwinkle, E. (Eric); Gudnason, V. (Vilmundur); Hofman, A. (Albert); Romero, J.R. (Jose Rafael); Breteler, M.M.B. (Monique); Schmidt, R. (Reinhold); Launer, L.J. (Lenore); Longstreth, W.T.
    In:Stroke, 41(2), 210 - 217. ISSN 0039-2499.

    Samenvatting:

    Background and Purpose-Previous studies examining genetic associations with MRI-defined brain infarct have yielded inconsistent findings. We investigated genetic variation underlying covert MRI infarct in persons without histories of transient ischemic attack or stroke. We performed meta-analysis of

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