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Prof.dr. A. Hofman Persoon

Prof.dr. A. Hofman

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  • HFE gene mutations increase the risk of coronary heart disease in women (2010)Open access

    Auteurs:Pardo Silva, M.C.; Njajou, O.T. (Omer); Alizadeh, B.Z. (Behrooz); Hofman, A. (Albert); Witteman, J.C.M. (Jacqueline); Duijn, van C.M. (Cock); Janssens, A.C.J.W. (Cécile)
    In:European Journal of Epidemiology, 25(9), 643 - 649. ISSN 0393-2990.

    Samenvatting:

    he purpose of the present study is to examine HFE gene mutations in relation to newly diagnosed (incident) coronary heart disease (CHD). In a population-based follow-up study of 7,983 individuals aged 55 years and older, we compared the risk of incident CHD between HFE carriers and non-carriers, ove

  • A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14 (2010)Open access

    Auteurs:Solouki, A.M. (Abbas); Verhoeven, V.J.M. (Virginie); Duijn, van C.M. (Cock); Verkerk, J.H.M. (Annemieke); Ikram, M.K. (Kamran); Hysi, P.G. (Pirro); Despriet, D.D.G. (Dominique); Koolwijk, van L.M.E. (Leonieke); Ho, L. (Lintje); Ramdas, W.D. (Wishal); Czudowska, M.A. (Monika); Kuijpers, R.W.A.M. (Robert); Amin, N. (Najaf); Struchalin, M.V. (Maksim); Aulchenko, Y.S. (Yurii); Rij, van G. (Gabriel); Riemslag, F.C.C. (Frans); Young, T.L. (Terry); Mackey, D.A. (David); Spector, T.D. (Timothy); Gorgels, T.G.M.F. (Theo); Willemse-Assink, J.J.M. (Jacqueline); Isaacs, A.J. (Aaron); Kramer, R. (Rogier); Swagemakers, S.M.A. (Sigrid); Bergen, A.A.B. (Arthur); Oosterhout, van A.A.L.J. (Andrew); Oostra, B.A. (Ben); Rivadeneira Ramirez, F. (Fernando); Uitterlinden, A.G. (André); Hofman, A. (Albert); Jong, de P.T.V.M. (Paulus); Hammond, C.J. (Christopher); Vingerling, J.R. (Hans); Klaver, C.C.W. (Caroline)
    In:Nature Genetics, 1 - 20. ISSN 1061-4036.

    Samenvatting:

    Refractive errors are the most common ocular disorders worldwide and may lead to blindness. Although this trait is highly heritable, identification of susceptibility genes has been challenging. We conducted a genome-wide association study for refractive error in 5,328 individuals from a Dutch popula

  • Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels (2010)

    Auteurs:O'Seaghdha, C.M. (Conall); Yang, Q. (Qiong Fang); Glazer, N.L. (Nicole); Leak, T.S. (Tennille); Dehghan, A. (Abbas); Smith, A.V. (Albert Vernon); Kao, W.H.L. (Wen); Lohman, K. (Kurt); Hwang, S.J.; Johnson, A.D. (Andrew); Hofman, A. (Albert); Uitterlinden, A.G. (André); Chen, C.; Brown, E.M. (Edward); Siscovick, D.S. (David); Harris, T.B. (Tamara); Psaty, B.M. (Bruce); Coresh, J. (Josef); Gudnason, V. (Vilmundur); Witteman, J.C.M. (Jacqueline); Liu, Y. (Yongmei); Kestenbaum, B. (Bryan); Fox, C.S. (Caroline); K̈ttgen, A. (Anna)
    In:Human Molecular Genetics, 19(21), 4296 - 4303. ISSN 0964-6906.

    Samenvatting:

    Serum calcium levels are tightly regulated. We performed genome-wide association studies (GWAS) in population-based studies participating in the CHARGE Consortium to uncover common genetic variations associated with total serum calcium levels. GWAS of serum calcium concentrations was performed in 20

  • Biological, clinical and population relevance of 95 loci for blood lipids (2010)

    Auteurs:Teslovich, T.M. (Tanya); Musunuru, K. (Kiran); Smith, A.V. (Albert Vernon); Edmondson, A.C. (Andrew); Stylianou, I.M. (Ioannis); Koseki, M. (Masahiro); Pirruccello, J.P. (James); Ripatti, S. (Samuli); Chasman, D.I. (Daniel); Willer, C.J. (Cristen); Johansen, C.T. (Christopher); Fouchier, S.W. (Sigrid); Isaacs, A. (Aaron); Peloso, G.M. (Gina); Barbalic, M. (maja); Ricketts, S.L. (Sally); Bis, J.C. (Joshua); Aulchenko, Y.S. (Yurii); Thorleifsson, G. (Gudmar); Feitosa, M.F. (Mary Furlan); Chambers, J. (John); Orho-Melander, M. (Marju); Melander, O. (Olle); Johnson, T. (Toby); Li, X. (Xiaohui); Guo, X. (Xiuqing); Shin Cho, Y. (Yoon); Jin Go, M. (Min); Jin Kim, Y. (Young); Lee, J.Y. (Jong Young); Park, T. (Taesung); Kim, K. (Kyunga); Sim, X. (Xueling); Twee-Hee Ong, R. (Rick); Croteau-Chonka, D.C. (Damien); Lange, L.A. (Leslie); Song, K. (Kijoung); Hua Zhao, J. (Jing); Yuan, X. (Xin); Luan, J.; Lamina, C. (Claudia); Ziegler, A.; Zhang, W. (Weibo); Zee, R.Y.L. (Robert); Wright, A.F. (Alan); Witteman, J.C.M. (Jacqueline); Wilson, J.F. (James); Willemsen, G.A.H.M. (Gonneke); Wichmann, H.E. (Heinz Erich); Whitfield, J. (John); Waterworth, D. (Dawn); Wareham, N.J. (Nicholas); Waeber, G. (Gérard); Vollenweider, P. (Peter); Voight, B.F. (Benjamin); Vitart, V. (Veronique); Uitterlinden, A.G. (André); Uda, M.; Tuomilehto, J. (Jaakko); Thompson, J.R. (John); Tanaka, T. (Toshiko); Surakka, I. (Ida); Stringham, H.M. (Heather); Spector, T.D. (Timothy); Soranzo, N. (Nicole); Smit, J.H. (Johannes); Sinisalo, J. (Juha); Silander, K. (Kaisa); Sijbrands, E.J.G. (Eric); Scuteri, A. (Angelo); Scott, J. (James); Schlessinger, D. (David); Sanna, S.; Salomaa, V. (Veikko); Saharinen, J. (Juha); Sabatti, C. (Chiara); Ruokonen, A. (Aimo); Rudan, I. (Igor); Rose, L.M. (Lynda); Roberts, R. (Robert); Rieder, M. (Mark); Psaty, B.M. (Bruce); Pramstaller, P.P. (Peter Paul); Pichler, I. (Irene); Perola, M. (Markus); Penninx, B.W.J.H. (Brenda); Pedersen, N.L. (Nancy); Pattaro, C. (Cristian); Parker, A.N. (Alex); Pare, G. (Guillaume); Oostra, B.A. (Ben); Nieminen, M.S. (Markku); Nickerson, D.A. (Deborah); Montgomery, G.W. (Grant); Meitinger, T. (Thomas); McPherson, R. (Ruth); McCarthy, M.I. (Mark); McArdle, W.L. (Wendy); Masson, D. (David); Martin, N.G. (Nicholas); Marroni, F. (Fabio); Mangino, M. (Massimo); Magnusson, P.K. (Patrik); Lucas, G. (Gavin); Luben, R.N. (Robert); Loos, R.J.F. (Ruth); Lokki, M.L.; Lettre, G. (Guillaume); Langenberg, C. (Claudia); Launer, L.J. (Lenore); Lakatta, E. (Edward); Laaksonen, R. (Reijo); Kyvik, K.O. (Kirsten Ohm); Kronenberg, F. (Florian); König, I.R. (Inke); Khaw, K-T. (Kay-Tee); Kaprio, J. (Jaakko); Kaplan, R.; Johansson, A. (Åsa); Jarvelin, M.R.; Cecile, A. (A.); Ingelsson, E. (Erik); Igl, W. (Wilmar); Kees Hovingh, G.; Hottenga, J.J.; Hofman, A. (Albert); Hicks, A.A. (Andrew); Hengstenberg, C. (Christian); Heid, I.M. (Iris); Hayward, C. (Caroline); Havulinna, A.S. (Aki); Hastie, N. (Nick); Harris, T.B. (Tamara); Haritunians, T. (Talin); Hall, A.S. (Alistair); Gyllensten, U. (Ulf); Guiducci, C. (Candace); Groop, L. (Leif); Gonzalez, E. (Elena); Gieger, C. (Christian); Freimer, N.B. (Nelson); Ferrucci, L. (Luigi); Erdmann, J. (Jeanette); Elliott, P. (Paul); Ejebe, K.G. (Kenechi); Döring, A. (Angela); Dominiczak, A. (Anna); Demissie, S. (Serkalem); Deloukas, P. (Panagiotis); Geus, de E.J.C. (Eco); Faire, de U. (Ulf); Crawford, G. (Gabe); Collins, F.S. (Francis); Chen, C.; Caulfield, M. (Mark); Campbell, H. (Harry); Burtt, N.P. (Noël); Bonnycastle, L.L. (Lori); Boomsma, D.I. (Dorret); Boekholdt, S.M. (Matthijs); Bergman, R.N. (Richard); Barroso, I. (Inês); Bandinelli, S. (Stefania); Ballantyne, C. (Christie); Assimes, T.L. (Themistocles); Quertermous, T. (Thomas); Altshuler, D. (David); Seielstad, M. (Mark); Wong, T.Y. (Tien); Tai, E.S. (Shyong); Feranil, A.B. (Alan); Kuzawa, C.W. (Christopher); Adair, L.S. (Linda); Taylor, H.A. (Herman); Borecki, I.B. (Ingrid); Gabriel, S.B. (Stacey); Holm, H. (Hilma); Thorsteinsdottir, U. (Unnur); Gudnason, V. (Vilmundur); Krauss, R.M. (Ronald); Mohlke, K.L. (Karen); Ordovas, J.M. (Jose); Munroe, P. (Patricia); Kooner, J.S. (Jaspal); Tall, A.R. (Alan); Hegele, R.A. (Robert); Kastelein, J.J. (John); Schadt, E.E. (Eric); Rotter, J.I. (Jerome); Boerwinkle, E. (Eric); Strachan, D.P. (David); Mooser, V. (Vincent); Zwart, J-A. (John-Anker); Reilly, M.P. (Muredach); Samani, N.J. (Nilesh); Schunkert, H. (Heribert); Cupples, L.A. (Adrienne); Sandhu, M.S. (Manjinder); Ridker, P.M. (Paul); Rader, D.J. (Daniel); Tikka-Kleemola, P. (Päivi); Peltonen, L. (Leena Johanna); Abecasis, G.R. (Gonçalo); Boehnke, M. (Michael); Kathiresan, S. (Sekar); O'Donnell, C.J. (Christopher)
    In:Nature: international weekly journal of science, 466(7307), 707 - 713. ISSN 0028-0836.

    Samenvatting:

    Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic intervention. We screened the genome for common variants

  • Improvement of risk prediction by genomic profiling: Reclassification measures versus the area under the receiver operating characteristic curve (2010)

    Auteurs:Mihaescu, R. (Raluca); Zitteren, van M. (Moniek); Hoek, van M. (Mandy); Sijbrands, E.J.G. (Eric); Uitterlinden, A.G. (André); Witteman, J.C.M. (Jacqueline); Hofman, A. (Albert); Hunink, M.G.M. (Myriam); Tikka-Kleemola, P. (Päivi); Janssens, A.C.J.W. (Cécile)
    In:American Journal of Epidemiology, 172(3), 353 - 361. ISSN 0002-9262.

    Samenvatting:

    Reclassification is observed even when there is no or minimal improvement in the area under the receiver operating characteristic curve (AUC), and it is unclear whether it indicates improved clinical utility. The authors investigated total reclassification, net reclassification improvement, and inte

  • Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six loci influencing serum magnesium levels (2010)Open access

    Auteurs:Meyer, T.E. (Tamra); Verwoert, G.C. (Germaine); Hwang, S.J.; Glazer, N.L. (Nicole); Smith, A.V. (Albert Vernon); Rooij, van F.J.A. (Frank); Ehret, G.B. (Georg); Boerwinkle, E. (Eric); Felix, J.F. (Janine); Leak, T.S. (Tennille); Harris, T.B. (Tamara); Yang, Q. (Qiong Fang); Dehghan, A. (Abbas); Aspelund, T. (Thor); Katz, R. (Ronit); Homuth, G. (Georg); Kocher, T. (Thomas); Rettig, R. (Rainer); Ried, J.S. (Janina); Gieger, C. (Christian); Prucha, H. (Hanna); Pfeufer, A. (Arne); Meitinger, T. (Thomas); Coresh, J. (Josef); Hofman, A. (Albert); Sarnak, M. (Mark); Chen, C.; Uitterlinden, A.G. (André); Chakravarti, A. (Aravinda); Psaty, B.M. (Bruce); Tikka-Kleemola, P. (Päivi); Linda Kao, W.H.; Witteman, J.C.M. (Jacqueline); Gudnason, V. (Vilmundur); Siscovick, D.S. (David); Fox, C.S. (Caroline); Köttgen, A. (Anna)
    In:P L o S Genetics (Print), 6(8). ISSN 1553-7390.

    Samenvatting:

    Magnesium, potassium, and sodium, cations commonly measured in serum, are involved in many physiological processes including energy metabolism, nerve and muscle function, signal transduction, and fluid and blood pressure regulation. To evaluate the contribution of common genetic variation to normal

  • Genome-wide association analysis identifies multiple loci related to resting heart rate (2010)

    Auteurs:Eijgelsheim, M. (Mark); Newton-Cheh, C. (Christopher); Sotoodehnia, N. (Nona); Bakker, de P.I.W. (Paul); Müller, M. (Martina); Morrison, A.C. (Alanna); Smith, A.V. (Albert Vernon); Isaacs, A. (Aaron); Sanna, S.; Dörr, M. (Marcus); Navarro, P. (Pau); Fuchsberger, C. (Christian); Nolte, I.M. (Ilja); Geus, de E.J.C. (Eco); Estrada, K. (Karol); Hwang, S.J.; Bis, J.C. (Joshua); Rückert, I.M.; Alonso, A. (Alvaro); Launer, L.J. (Lenore); Hottenga, J.J.; Rivadeneira Ramirez, F. (Fernando); Noseworthy, P.A. (Peter); Rice, K. (Kenneth); Perz, S. (Siegfried); Arking, D.E. (Dan); Spector, T.D. (Tim); Kors, J.A. (Jan); Aulchenko, Y.S. (Yurii); Tarasov, K.V. (Kirill); Homuth, G. (Georg); Wild, S.H. (Sarah); Marroni, F. (Fabio); Gieger, C. (Christian); Licht, C.M. (Carmilla); Prineas, R.J. (Ronald); Hofman, A. (Albert); Rotter, J.I. (Jerome); Hicks, A.A. (Andrew); Ernst, F.D.J. (Florian); Najjar, S.S. (Samer); Wright, A.F. (Alan); Peters, A. (Annette); Fox, E.R. (Ervin); Oostra, B.A. (Ben); Kroemer, H.K. (Heyo); Couper, D.J. (David); Völzke, H. (Henry); Campbell, H. (Harry); Meitinger, T. (Thomas); Uda, M.; Witteman, J.C.M. (Jacqueline); Psaty, B.M. (Bruce); Wichmann, H.E. (Heinz Erich); Harris, T.B. (Tamara); Kääb, S. (Stefan); Siscovick, D.S. (David); Jamshidi, Y. (Yalda); Uitterlinden, A.G. (André); Folsom, A.R. (Aaron); Larson, M.G. (Martin); Wilson, J.F. (James); Penninx, B.W.J.H. (Brenda); Snieder, H. (Harold); Pramstaller, P.P. (Peter Paul); Tikka-Kleemola, P. (Päivi); Lakatta, E. (Edward); Felix, S.B. (Stephan); Gudnason, V. (Vilmundur); Pfeufer, A. (Arne); Heckbert, S.R. (Susan); Stricker, B.H.Ch. (Bruno); Boerwinkle, E. (Eric); O'Donnell, C.J. (Christopher)
    In:Human Molecular Genetics, 19(19), 3885 - 3894. ISSN 0964-6906.

    Samenvatting:

    Higher resting heart rate is associated with increased cardiovascular disease and mortality risk. Though heritable factors play a substantial role in population variation, little is known about specific genetic determinants. This knowledge can impact clinical care by identifying novel factors that i

  • Distribution of echocardiographic parameters and their associations with cardiovascular risk factors in the Rotterdam Study (2010)Open access

    Auteurs:Kardys, I. (Isabella); Deckers, J.W. (Jaap); Stricker, B.H.Ch. (Bruno); Vletter, W.B. (Wim); Hofman, A. (Albert); Witteman, J.C.M. (Jacqueline)
    In:European Journal of Epidemiology, 25(7), 481 - 490. ISSN 0393-2990.

    Samenvatting:

    Insight into echocardiographic parameters in the general population may facilitate early recognition of ventricular dysfunction, reducing the population morbidity and mortality of heart failure. We examined the distribution of structural, systolic and diastolic echocardiographic parameters and their

  • A prospective analysis of elevated fasting glucose levels and cognitive function in older people: Results from PROSPER and the Rotterdam Study (2010)

    Auteurs:Euser, S.M. (Sjoerd); Sattar, N. (Naveed); Witteman, J.C.M. (Jacqueline); Bollen, E.L.E.M. (Eduard); Sijbrands, E.J.G. (Eric); Hofman, A. (Albert); Perry, I.J. (Ivan); Breteler, M.M.B. (Monique); Westendorp, R.G.J. (Rudi)
    In:Diabetes, 59(7), 1601 - 1607. ISSN 0012-1797.

    Samenvatting:

    OBJECTIVE - To investigate the relationship between fasting glucose levels, insulin resistance, and cognitive impairment in old age. Diabetes is associated with cognitive impairment in older people. However, the link between elevated fasting glucose levels and insulin resistance in nondiabetic indiv

  • Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis (2010)

    Auteurs:Voight, B.F. (Benjamin); Scott, L.J. (Laura); Steinthorsdottir, V. (Valgerdur); Morris, A.D. (Andrew); Dina, C. (Christian); Welch, R.P. (Ryan); Zeggini, E. (Eleftheria); Huth, C. (Cornelia); Aulchenko, Y.S. (Yurii); Thorleifsson, G. (Gudmar); McCulloch, L.J. (Laura); Ferreira, T. (Teresa); Grallert, H. (Harald); Amin, N. (Najaf); Wu, G. (Guanming); Willer, C.J. (Cristen); Raychaudhuri, S. (Soumya); McCarroll, S.A. (Steven); Langenberg, C. (Claudia); Hofmann, O.M. (Oliver); Dupuis, J. (Josée); Qi, L. (Lu); Segrè, A.V. (Ayellet); Hoek, van M. (Mandy); Navarro, P. (Pau); Ardlie, K.G. (Kristin); Balkau, B. (Beverley); Benediktsson, R. (Rafn); Bennett, A.J. (Amanda); Blagieva, R. (Roza); Boerwinkle, E. (Eric); Bonnycastle, L.L. (Lori); Boström, K.B. (Kristina Bengtsson); Bravenboer, B. (Bert); Bumpstead, S. (Suzannah); Burtt, N.P. (Noël); Charpentier, G. (Guillaume); Chines, P.S. (Peter); Cornelis, M. (Marilyn); Couper, D.J. (David); Crawford, G. (Gabe); Doney, A.S.F. (Alex); Elliott, K.S. (Katherine); Erdos, M.R. (Michael); Fox, C.S. (Caroline); Franklin, C.S. (Christopher); Ganser, M. (Martha); Gieger, C. (Christian); Grarup, N. (Niels); Green, T. (Todd); Griffin, S. (Simon); Groves, C.J. (Christopher); Guiducci, C. (Candace); Hadjadj, S. (Samy); Hassanali, N. (Neelam); Herder, C. (Christian); Isomaa, B. (Bo); Jackson, A.U. (Anne); Johnson, P.R.V. (Paul); Jørgensen, T. (Torben); Kao, W.H.L. (Wen); Klopp, N. (Norman); Kong, A. (Augustine); Kraft, P. (Peter); Kuusisto, J. (Johanna); Lauritzen, T. (Torsten); Li, M. (Man); Lieverse, A. (Aloysius); Lindgren, C.M. (Cecilia); Lyssenko, V. (Valeriya); Marre, M. (Michel); Meitinger, T. (Thomas); Midthjell, K. (Kristian); Morken, M.A. (Mario); Narisu, N. (Narisu); Nilsson, P. (Peter); Owen, K.R. (Katharine); Payne, F. (Felicity); Perry, J.R.B. (John); Petersen, A.K.; Platou, C. (Carl); Proença, C. (Christine); Prokopenko, I. (Inga); Rathmann, W. (Wolfgang); Rayner, N.W. (N William); Robertson, N.R. (Neil); Rocheleau, G. (Ghislain); Roden, M. (Michael); Sampson, M.J. (Michael); Saxena, R. (Richa); Shields, B.M. (Beverley); Shrader, P. (Peter); Sigurdsson, G. (Gunnar); Sparsø, T. (Thomas); Strassburger, K. (Klaus); Stringham, H.M. (Heather); Sun, Q. (Qi); Swift, A.J. (Amy); Thorand, B. (Barbara); Tichet, J. (Jean); Tuomi, T. (Tiinamaija); Dam, van R.M. (Rob); Haeften, van T.W. (Timon); Herpt, van T.W. (Thijs); Vliet-Ostaptchouk, van J.V. (Jana); Walters, G.B. (Bragi); Weedon, M.N. (Michael); Wijmenga, C. (Cisca); Witteman, J.C.M. (Jacqueline); Bergman, R.N. (Richard); Cauchi, S. (Stephane); Collins, F.S. (Francis); Gloyn, A.L. (Anna); Gyllensten, U. (Ulf); Hansen, T. (Torben); Hide, W.A. (Winston); Hitman, G.A. (Graham); Hofman, A. (Albert); Hunter, D. (David); Hveem, K. (Kristian); Laakso, M. (Markku); Mohlke, K.L. (Karen); Palmer, C.N.A. (Colin); Pramstaller, P.P. (Peter Paul); Rudan, I. (Igor); Sijbrands, E.J.G. (Eric); Stein, L.D. (Lincoln); Tuomilehto, J. (Jaakko); Uitterlinden, A.G. (André); Walker, M. (Mark); Wareham, N.J. (Nicholas); Watanabe, R.M. (Richard); Abecasis, G.R. (Gonçalo); Boehm, B.O. (Bernhard); Campbell, H. (Harry); Daly, M. (Mark); Hattersley, A.T. (Andrew); Hu, F.B. (Frank); Meigs, J.B. (James); Pankow, J.S. (James); Pedersen, O. (Oluf); Wichmann, H.E. (Erich); Barroso, I. (Inês); Florez, J.C. (Jose); Frayling, T.M. (Timothy); Groop, L. (Leif); Sladek, R. (Rob); Thorsteinsdottir, U. (Unnur); Wilson, J.F. (James); Illig, T. (Thomas); Froguel, P. (Philippe); Tikka-Kleemola, P. (Päivi); Zwart, J-A. (John-Anker); Altshuler, D. (David); Boehnke, M. (Michael); McCarthy, M.I. (Mark)
    In:Nature Genetics, 42(7), 579 - 589. ISSN 1061-4036.

    Samenvatting:

    By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined

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