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Prof.dr. A. Hofman Persoon

Prof.dr. A. Hofman

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  • A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22 (2010)

    Auteurs:Kerkhof, H.J.M. (Hanneke); Lories, R.J. (Rik); Meulenbelt, I. (Ingrid); Jonsdottir, I. (Ingileif); Valdes, A.M. (Ana Maria); Arp, P.P. (Pascal); Ingvarsson, T. (Torvaldur); Jhamai, M. (Mila); Jonsson, H. (Helgi); Stolk, L. (Lisette); Thorleifsson, G. (Gudmar); Zhai, G. (Guangju); Zhang, F. (Feng); Zhu, Y. (Yicheng); Breggen, van der R. (Ruud); Carr, A.M. (Andrew); Doherty, M. (Michael); Felson, D.; Gonzalez, A. (Antonio); Halldorsson, B.V. (Bjarni); Hart, D.J. (Deborah); Hauksson, V.B. (Valdimar); Hofman, A. (Albert); Ioannidis, J.P.A. (John); Kloppenburg, M. (Margreet); Lane, N.E. (Nancy); Loughlin, J. (John); Luyten, F.P. (Frank); Nevitt, M.C. (Michael); Parimi, N. (Neeta); Pols, H.A.P. (Huib); Rivadeneira Ramirez, F. (Fernando); Slagboom, E. (Eline); Styrkarsdottir, U. (Unnur); Tsezou, A. (Aspasia); Putte, van de T. (Tom); Zmuda, J. (Joseph); Spector, T.D. (Timothy); Zwart, J-A. (John-Anker); Uitterlinden, A.G. (André); Meurs, van J.B.J. (Joyce)
    In:Arthritis Care and Research, 62(2), 499 - 510. ISSN 0004-3591.

    Samenvatting:

    Objective. To identify novel genes involved in osteoarthritis (OA), by means of a genome-wide association study. Methods. We tested 500,510 single-nucleotide polymorphisms (SNPs) in 1,341 Dutch Caucasian OA cases and 3,496 Dutch Caucasian controls. SNPs associated with at least 2 OA phenotypes were

  • Genome-wide association study of PR interval (2010)

    Auteurs:Pfeufer, A. (Arne); Noord, van C. (Charlotte); Marciante, K. (Kristin); Arking, D.E. (Dan); Larson, M.G. (Martin); Smith, A.V. (Albert Vernon); Tarasov, K.V. (Kirill); Müller, M. (Martina); Sotoodehnia, N. (Nona); Sinner, M.F. (Moritz); Verwoert, G.C. (Germaine); Li, M. (Man); Kao, W.H.L. (Wen); Köttgen, A. (Anna); Coresh, J. (Josef); Bis, J.C. (Joshua); Psaty, B.M. (Bruce); Rice, K. (Kenneth); Rotter, J.I. (Jerome); Rivadeneira Ramirez, F. (Fernando); Hofman, A. (Albert); Kors, J.A. (Jan); Stricker, B.H.Ch. (Bruno); Uitterlinden, A.G. (André); Tikka-Kleemola, P. (Päivi); Beckmann, B.M. (Britt); Sauter, W. (Wiebke); Gieger, C. (Christian); Lubitz, S.A. (Steven); Newton-Cheh, C. (Christopher); Wang, T.J. (Thomas); Magnani, J.W. (Jared); Schnabel, R. (Renate); Chung, M.K. (Mina); Barnard, J. (John); Wagoner, van D.R. (David); Vasan, R.S. (Ramachandran Srini); Aspelund, T. (Thor); Eiriksdottir, G. (Gudny); Harris, T.B. (Tamara); Launer, L.J. (Lenore); Najjar, S.S. (Samer); Lakatta, E. (Edward); Schlessinger, D. (David); Uda, M.; Abecasis, G.R. (Gonçalo); Artto, V. (Ville); Ehret, G.B. (Georg); Boerwinkle, E. (Eric); Chakravarti, A. (Aravinda); Soliman, E.Z. (Elsayed); Lunetta, K.L. (Kathryn); Perz, S. (Siegfried); Wichmann, H.E. (Erich); Meitinger, T. (Thomas); Levy, D. (Daniel); Gudnason, V. (Vilmundur); Ellinor, P.T. (Patrick); Sanna, S.; Kääb, S. (Stefan); Witteman, J.C.M. (Jacqueline); Alonso, A. (Alvaro); Benjamin, E.J. (Emelia); Heckbert, S.R. (Susan)
    In:Nature Genetics, 42(2), 153 - 159. ISSN 1061-4036.

    Samenvatting:

    The electrocardiographic PR interval (or PQ interval) reflects atrial and atrioventricular nodal conduction, disturbances of which increase risk of atrial fibrillation. We report a meta-analysis of genome-wide association studies for PR interval from seven population-based European studies in the CH

  • Insulin VNTR and IGF-1 promoter region polymorphisms are not associated with body composition in early childhood: The generation R study (2010)Open access

    Auteurs:Maas, J.A.J.B.M. (Janneke); Mook-Kanamori, D.O. (Dennis); Ay, L. (Lamise); Steegers-Theunissen, R.P.M. (Regine); Tikka-Kleemola, P. (Päivi); Hofman, A. (Albert); Hokken-Koelega, A.C.S. (Anita); Jaddoe, V.W.V. (Vincent)
    In:Hormone Research in Paediatrics, 73(2), 120 - 127. ISSN 1663-2818.

    Samenvatting:

    Objective: The objective of this study was to examine the associations between insulin gene variable number of tandem repeats (INS VNTR) and insulin-like growth factor 1 (IGF1) gene promoter region polymorphisms with body composition in early childhood. Methods: This study was embedded in an ongoing

  • New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (2010)

    Auteurs:Dupuis, J. (Josée); Langenberg, C. (Claudia); Prokopenko, I. (Inga); Saxena, R. (Richa); Soranzo, N. (Nicole); Jackson, A.U. (Anne); Wheeler, E. (Eleanor); Glazer, N.L. (Nicole); Bouatia-Naji, N. (Nabila); Gloyn, A.L. (Anna); Lindgren, C.M. (Cecilia); Mägi, R. (Reedik); Morris, A.P. (Andrew); Randall, J.C. (Joshua); Johnson, T. (Toby); Elliott, P. (Paul); Rybin, D. (Denis); Thorleifsson, G. (Gudmar); Steinthorsdottir, V. (Valgerdur); Henneman, P. (Peter); Grallert, H. (Harald); Dehghan, A. (Abbas); JanHottenga, J. (Jouke); Franklin, C.S. (Christopher); Navarro, P. (Pau); Song, K. (Kijoung); Goel, A. (Anuj); Perry, J.R.B. (John); Egan, J.M. (Josephine); Lajunen, T. (Taina); Grarup, N. (Niels); Sparsø, T. (Thomas); Doney, A.S.F. (Alex); Voight, B.F. (Benjamin); Stringham, H.M. (Heather); Li, M. (Man); Kanoni, S. (Stavroula); Shrader, P. (Peter); Cavalcanti-Proença, C. (Christine); Kumari, M. (Meena); Qi, L. (Lu); Timpson, N. (Nicholas); Gieger, C. (Christian); Zabena, C. (Carina); Rocheleau, G. (Ghislain); Ingelsson, E. (Erik); An, P. (Ping); O´Connell, J.R.; Luan, J.; McCarroll, S.A. (Steven); Payne, F. (Felicity); Roccasecca, R.M.; Pattou, F. (François); Sethupathy, P. (Praveen); Ardlie, K.G. (Kristin); Ariyurek, Y. (Yavuz); Balkau, B. (Beverley); Barter, P. (Phil); Beilby, J.P. (John); Ben-Shlomo, Y.; Benediktsson, R. (Rafn); Bennett, A.J. (Amanda); Bergmann, S. (Sven); Bochud, M. (Murielle); Boerwinkle, E. (Eric); Bonnefond, A. (Amélie); Bonnycastle, L.L. (Lori); Borch-Johnsen, K.; Böttcher, Y. (Yvonne); Brunner, E. (Eric); Bumpstead, S. (Suzannah); Charpentier, G. (Guillaume); IdaChen, der Y. (Yii); Chines, P.S. (Peter); Clarke, R.; McOin, L.J. (Lachlan); Cooper, M.N. (Matthew); Cornelis, M. (Marilyn); Crawford, G. (Gabe); Crisponi, L. (Laura); Day, I.N.M. (Ian); Geus, de E.J.C. (Eco); Delplanque, J. (Jerome); Dina, C. (Christian); Erdos, M.R. (Michael); Fedson, A.C. (Annette); Fischer-Rosinsky, A. (Antje); Forouhi, N.G. (Nita); Fox, C.S. (Caroline); Frants, R.R. (Rune); GraziaFranzosi, M. (Maria); Galan, P. (Pilar); Goodarzi, M. (Mark); Graessler, J. (Jürgen); Groves, C.J. (Christopher); Grundy, S.M. (Scott); Gwilliam, R. (Rhian); Gyllensten, U. (Ulf); Hadjadj, S. (Samy); Hallmans, G. (Göran); Hammond, N. (Naomi); Han, X. (Xijing); -LiisaHartikainen, A. (Anna); Hassanali, N. (Neelam); Hayward, C. (Caroline); Heath, S.C. (Simon); Hercberg, S. (Serge); Herder, C. (Christian); Hicks, A.A. (Andrew); Hillman, D.R. (David); Hingorani, A. (Aroon); Hofman, A. (Albert); Hui, J. (Jennie); Hung, J.; Isomaa, B. (Bo); Jørgensen, T. (Torben); Jula, A. (Antti); Kaakinen, M. (Marika); Kaprio, J. (Jaakko); AnteroKesaniemi, Y.; Kivimaki, M. (Mika); Knight, B. (Beatrice); Koskinen, S. (Seppo); Kovacs, P. (Peter); Kyvik, K.O. (Kirsten Ohm); Lathrop, G.M. (Mark); Lawlor, D.A. (Debbie); Bacquer, O.L. (Olivier); Lecoeur, C. (Cécile); Lyssenko, V. (Valeriya); Mahley, R. (Robert); Mangino, M. (Massimo); Manning, A.K. (Alisa); TeresaMartínez-Larrad, M. (María); McAteer, J.B. (Jarred); McCulloch, L.J. (Laura); McPherson, R. (Ruth); Meisinger, C. (Christa); Melzer, D. (David); Meyre, D. (David); Mitchell, B.D. (Braxton); Morken, M.A. (Mario); Mukherjee, S. (Sutapa); Naitza, S. (Silvia); Narisu, N. (Narisu); Neville, M.J. (Matthew); Oostra, B.A. (Ben); Orrù, M. (Marco); Pakyz, R. (Ruth); APalmer, C.N. (Colin); Paolisso, G. (Giuseppe); Pattaro, C. (Cristian); Pearson, D. (Daniel); Peden, J. (John); Pedersen, N.L. (Nancy); Perola, M. (Markus); Pfeiffer, A.F.H. (Andreas); Pichler, I. (Irene); Polasek, O. (Ozren); Posthuma, D. (Danielle); Potter, S.C. (Simon); Pouta, A. (Anneli); Province, M.A. (Mike); Psaty, B.M. (Bruce); Rathmann, W. (Wolfgang); Rayner, N.W. (N William); Rice, K. (Kenneth); Ripatti, S. (Samuli); Rivadeneira Ramirez, F. (Fernando); Roden, M. (Michael); Rolandsson, O. (Olov); Sandbaek, A. (Annelli); Sandhu, M.S. (Manjinder); Sanna, S.; Sayer, A.A.; Scheet, P. (Paul); Scott, L.J. (Laura); Seedorf, U. (Udo); Sharp, S.J. (Stephen); Shields, B.M. (Beverley); Sigursson, G. (Gunnar); Sijbrands, E.J.G. (Eric); Silveira, A. (Angela); Simpson, L. (Laila); Singleton, A. (Andrew); Smith, N.L. (Nicholas); Sovio, U. (Ulla); Swift, A.J. (Amy); Syddall, H. (Holly); -ChristineSyvänen, A. (Ann); Tanaka, T. (Toshiko); Thorand, B. (Barbara); Tichet, J. (Jean); Tönjes, A. (Anke); Tuomi, T. (Tiinamaija); Uitterlinden, A.G. (André); Dijk, van K.W.; Hoek, M.V.; Varma, D. (Dhiraj); Visvikis-Siest, S. (Sophie); Vitart, V. (Veronique); Vogelzangs, N. (Nicole); Waeber, G. (Gérard); Wagner, P.J. (Peter); Walley, A. (Andrew); BragiWalters, G.; Ward, K.L. (Kim); Watkins, H. (Hugh); Weedon, M.N. (Michael); Wild, S.H. (Sarah); Willemsen, G.A.H.M. (Gonneke); MWitteman, J.C. (Jaqueline); GYarnell, J.W. (John); Zeggini, E. (Eleftheria); Zelenika, D. (Diana); Zethelius, B. (Björn); Zhai, G. (Guangju); Zhao, J.H.; Zillikens, M.C. (Carola); Borecki, I.B. (Ingrid); Loos, R.J.F. (Ruth); Meneton, P. (Pierre); Magnusson, P.K. (Patrik); Nathan, D.M. (David); Williams, G.H. (Gordon); Hattersley, A.T. (Andrew); Silander, K. (Kaisa); Salomaa, V. (Veikko); Bornstein, S.R. (Stefan); Schwarz, P. (Peter); Spranger, J. (Jürgen); Karpe, F. (Fredrik); Shuldiner, A.R. (Alan); Dedoussis, G.V. (George); Serrano-Ríos, M. (Manuel); Lind, L. (Lars); Palmer, C. (Cameron); Hu, F.B. (Frank); Franks, P.W. (Paul); Ebrahim, S. (Shah); Marmot, M. (Michael); Linda Kao, W.H.; Pankow, J.S. (James); Sampson, M.J. (Michael); Kuusisto, J. (Johanna); Laakso, M. (Markku); Hansen, T. (Torben); Pramstaller, P.P. (Peter Paul); Wichmann, H.E. (Erich); Illig, T. (Thomas); Rudan, I. (Igor); Wright, A.F. (Alan); Stumvoll, M. (Michael); Campbell, H. (Harry); Wilson, J.F. (James); Bergman, R.N. (Richard); Buchanan, T.A. (Thomas); Collins, F.S. (Francis); Mohlke, K.L. (Karen); Tuomilehto, J. (Jaakko); Valle, T.T. (Timo); Altshuler, D. (David); Rotter, J.I. (Jerome); Siscovick, D.S. (David); Penninx, B.W.J.H. (Brenda); Boomsma, D.I. (Dorret); Deloukas, P. (Panagiotis); Spector, T.D. (Timothy); Frayling, T.M. (Timothy); Ferrucci, L. (Luigi); Kong, A. (Augustine); Thorsteinsdottir, U. (Unnur); Zwart, J-A. (John-Anker); Tikka-Kleemola, P. (Päivi); Aulchenko, Y.S. (Yurii); Cao, A. (Antonio); Scuteri, A. (Angelo); Schlessinger, D. (David); Uda, M.; Ruokonen, A. (Aimo); -RiittaJarvelin, M. (Marjo); Waterworth, D. (Dawn); Vollenweider, P. (Peter); Peltonen, L. (Leena Johanna); Mooser, V. (Vincent); Abecasis, G.R. (Gonçalo); Wareham, N.J. (Nicholas); Sladek, R. (Rob); Froguel, P. (Philippe); Watanabe, R.M. (Richard); Meigs, J.B. (James); Groop, L. (Leif); Boehnke, M. (Michael); McCarthy, M.I. (Mark); Florez, J.C. (Jose); Barroso, I. (Inês)
    In:Nature Genetics, 42(2), 105 - 116. ISSN 1061-4036.

    Samenvatting:

    Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up t

  • Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function (2010)

    Auteurs:Hancock, D.B. (Dana); Eijgelsheim, M. (Mark); Wilk, J.B. (Jemma); Gharib, S.A. (Sina); Loehr, L.R. (Laura); Marciante, K. (Kristin); Franceschini, N. (Nora); Durme, van Y.M.T.A.; Chen, T.H.; Barr, R.G. (Graham); Schabath, M.B. (Matthew); Couper, D.J. (David); Brusselle, G.G. (Guy); Psaty, B.M. (Bruce); Tikka-Kleemola, P. (Päivi); Rotter, J.I. (Jerome); Uitterlinden, A.G. (André); Hofman, A. (Albert); Punjabi, N.M. (Naresh); Rivadeneira Ramirez, F. (Fernando); Morrison, A.C. (Alanna); Enright, P.L. (Paul); North, K.E. (Kari); Heckbert, S.R. (Susan); Lumley, T. (Thomas); Stricker, B.H.Ch. (Bruno); O'Connor, G.T. (George); London, S.J. (Stephanie)
    In:Nature Genetics, 42(1), 45 - 52. ISSN 1061-4036.

    Samenvatting:

    Spirometric measures of lung function are heritable traits that reflect respiratory health and predict morbidity and mortality. We meta-analyzed genome-wide association studies for two clinically important lung-function measures: forced expiratory volume in the first second (FEV1) and its ratio to f

  • The association of serum testosterone levels and ventricular repolarization (2010)Open access

    Auteurs:Noord, van C. (Charlotte); Dörr, M. (Marcus); Sturkenboom, M.C.J.M. (Miriam); Straus, S.M. (Sabine); Reffelmann, T. (Thorsten); Felix, S.B. (Stephan); Hofman, A. (Albert); Kors, J.A. (Jan); Haring, R. (Robin); Jong, de F.H. (Frank); Nauck, M. (Matthias); Uitterlinden, A.G. (André); Wallaschofski, H. (Henri); Witteman, J.C.M. (Jacqueline); Völzke, H. (Henry); Stricker, B.H.Ch. (Bruno)
    In:European Journal of Epidemiology, 25(1), 21 - 28. ISSN 0393-2990.

    Samenvatting:

    It is assumed that testosterone is an important regulator of gender-related differences in ventricular repolarization. Therefore, our aim was to study whether serum levels of testosterone are associated with QTc, QT and RR interval variation. Setting: two independent population-based cohort studies.

  • Recent trends in cardiovascular epidemiology (2009)Open access

    Auteur:Hofman, A. (Albert)
    In:European Journal of Epidemiology, 24(12), 721 - 723. ISSN 0393-2990.

  • Residential traffic exposure and pregnancy-related outcomes: A prospective birth cohort study (2009)Open access

    Auteurs:Hooven, van den E.H. (Edith); Jaddoe, V.W.V. (Vincent); Kluizenaar, de Y. (Yvonne); Hofman, A. (Albert); Mackenbach, J.P. (Johan); Steegers-Theunissen, R.P.M. (Regine); Miedema, H.M. (Henk); Pierik, F.H. (Frank)
    In:Environmental Health: A Global Access Science Source, 8(1). ISSN 1476-069x.

    Samenvatting:

    Background. The effects of ambient air pollution on pregnancy outcomes are under debate. Previous studies have used different air pollution exposure assessment methods. The considerable traffic-related intra-urban spatial variation needs to be considered in exposure assessment. Residential proximity

  • Veertig jaar epidemiologie aan de Erasmus Universiteit 1969-2009 (2009)Open access

    Auteurs:Hofman, A. (Albert); Keijer, M.; Paak, J.

    Samenvatting:

    Waarschijnlijk telt geen land ter wereld per hoofd van de bevolking zoveel epidemiologen als Nederland. De Nederlandse Vereniging van Epidemiologen is een van de grootste in Europa. Elke maand verschijnen in de beste internationale wetenschappelijke tijdschriften resultaten van Nederlands epidemiolo

  • Type 2 diabetes gene TCF7L2 polymorphism is not associated with fetal and postnatal growth in two birth cohort studies (2009)Open access

    Auteurs:Mook-Kanamori, D.O. (Dennis); Kort, de S.W.K. (Sandra); Tikka-Kleemola, P. (Päivi); Uitterlinden, A.G. (André); Hofman, A. (Albert); Moll, H.A. (Henriëtte); Steegers-Theunissen, R.P.M. (Regine); Hokken-Koelega, A.C.S. (Anita); Jaddoe, V.W.V. (Vincent)
    In:B M C Medical Genetics, 10. ISSN 1471-2350.

    Samenvatting:

    Background: An inverse association between birth weight and the risk of developing type 2 diabetes (T2D) in adulthood has been reported. This association may be explained by common genetic variants related to insulin secretion and resistance, since insulin is the most important growth factor in feta

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