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Prof.dr. A. Hofman Person

Prof.dr. A. Hofman

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  • Association of eGFR-related loci identified by GWAS with incident CKD and ESRD (2011)Open access

    Authors:Böger, C.A. (Carsten); Gorski, M. (Mathias); Li, M. (Man); Hoffmann, M.M. (Michael); Huang, C. (Chunmei); Yang, Q. (Qiong Fang); Teumer, A. (Alexander); Krane, V. (Vera); O'Seaghdha, C.M. (Conall); Kutalik, Z. (Zoltán); Wichmann, H.E. (Heinz Erich); Haak, T. (Thomas); Boes, E. (Eva); Coassin, S. (Stefan); Coresh, J. (Josef); Kollerits, B. (Barbara); Haun, M. (Margot); Paulweber, B. (Bernhard); Köttgen, A. (Anna); Shlipak, M.G. (Michael); Powe, N. (Neil); Hwang, S.J.; Dehghan, A. (Abbas); Rivadeneira Ramirez, F. (Fernando); Uitterlinden, A.G. (André); Hofman, A. (Albert); Beckmann, J.S. (Jacques); Krämer, B.K. (Bernhard); Witteman, J.C.M. (Jacqueline); Bochud, M. (Murielle); Siscovick, D.S. (David); Rettig, R. (Rainer); Kronenberg, F. (Florian); Wanner, C. (Christoph); Thadhani, R.I. (Ravi); Heid, I.M. (Iris); Fox, C.S. (Caroline); Kao, W.H.L. (Wen)
    In:P L o S Genetics (Print), 7(9). ISSN 1553-7390.

    Abstract:

    Family studies suggest a genetic component to the etiology of chronic kidney disease (CKD) and end stage renal disease (ESRD). Previously, we identified 16 loci for eGFR in genome-wide association studies, but the associations of these single nucleotide polymorphisms (SNPs) for incident CKD or ESRD

  • The Rotterdam Study: 2012 objectives and design update (2011)Open access

    Authors:Hofman, A. (Albert); Duijn, van C.M. (Cock); Franco, O.H. (Oscar); Ikram, M.A. (Mohammed Arfan); Janssen, H.L.A. (Harry); Klaver, C.C.W. (Caroline); Kuipers, E.J. (Ernst); Nijsten, T.E.C. (Tamar); Stricker, B.H.Ch. (Bruno); Tiemeier, H. (Henning); Uitterlinden, A.G. (André); Vernooij, M.W. (Meike); Witteman, J.C.M. (Jacqueline)
    In:European Journal of Epidemiology, 2011, 1 - 30. ISSN 0393-2990.

    Abstract:

    Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, oncological, and respiratory diseases. As of 2008, 14,926 subjects a

  • Meta-analysis of genome-wide association for migraine in six population-based European cohorts (2011)

    Authors:Ligthart, L. (Lannie); Vries, de B. (Boukje); Smith, A.V. (Albert Vernon); Ikram, M.A. (Mohammed Arfan); Amin, N. (Najaf); Hottenga, J.J.; Koelewijn, S.C. (Stephany C.); Kattenberg, V.M. (Mathijs); Moor, de M.H.M.; Janssens, A.C.J.W. (Cécile); Aulchenko, Y.S. (Yurii); Oostra, B.A. (Ben); Geus, de E.J.C. (Eco); Smit, J.H. (Johannes); Zitman, F.G. (Frans); Uitterlinden, A.G. (André); Hofman, A. (Albert); Willemsen, G.A.H.M. (Gonneke); Nyholt, D.R. (Dale); Montgomery, G.W. (Grant); Terwindt, G.M. (Gisela); Gudnason, V. (Vilmundur); Penninx, B.W.J.H. (Brenda); Breteler, L.M.T. (Leonie); Ferrari, M.D. (Michel); Launer, L.J. (Lenore); Tikka-Kleemola, P. (Päivi); Maagdenberg, van den A.M.J.M. (Arn); Boomsma, D.I. (Dorret)
    In:European Journal of Human Genetics, 19(8), 901 - 907. ISSN 1018-4813.

    Abstract:

    Migraine is a common neurological disorder with a genetically complex background. This paper describes a meta-analysis of genome-wide association (GWA) studies on migraine, performed by the Dutch-Icelandic migraine genetics (DICE) consortium, which brings together six population-based European migra

  • Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile (2011)

    Authors:Kilpeläinen, T.O. (Tuomas); Zillikens, M.C. (Carola); Stancáková, A. (Alena); Finucane, F.M. (Francis); Ried, J.S. (Janina); Langenberg, C. (Claudia); Zhang, W. (Weihua); Beckmann, J.S. (Jacques); Luan, J.; Vandenput, L. (Liesbeth); Styrkarsdottir, U. (Unnur); Zhou, Y. (Yanhua); Smith, A.V. (Albert Vernon); Zhao, J.H. (Jing); Amin, N. (Najaf); Vedantam, S. (Sailaja); Shin, S.-Y.; Haritunians, T. (Talin); Fu, M. (Mao); Feitosa, M.F. (Mary Furlan); Kumari, M. (Meena); Halldorsson, B.V. (Bjarni); Tikkanen, E. (Emmi); Mangino, M. (Massimo); Hayward, C. (Caroline); Song, C. (Ci); Arnold, A.M. (Alice); Oostra, B.A. (Ben); Campbell, H. (Harry); Cupples, L.A. (Adrienne); Davis, K.E. (Kathryn); Döring, A. (Angela); Eiriksdottir, G. (Gudny); Estrada Gil, K. (Karol); Fernández-Real, J.M.; Garcia, M. (Melissa); Gieger, C. (Christian); Glazer, N.L. (Nicole); Guiducci, C. (Candace); Hofman, A. (Albert); Humphries, S.E. (Steve); Isomaa, B. (Bo); Jacobs, L.C. (Leonie); Jula, A. (Antti); Karasik, D. (David); Karlsson, M.K. (Magnus); Khaw, K-T. (Kay-Tee); Kim, L.J. (Lauren); Kivimaki, M. (Mika); Klopp, N. (Norman); Kuhnel, B. (Brigitte); Kuusisto, J. (Johanna); Liu, Y. (Yongmei); Ljunggren, Ö.; Lorentzon, M. (Mattias); Luben, R.N. (Robert); McKnight, B. (Barbara); Mellström, D. (Dan); Mitchell, B.D. (Braxton); Mooser, V. (Vincent); Moreno, J.M.; Männistö, S. (Satu); O'Connell, J.R. (Jeffery); Pascoe, L. (Laura); Peltonen, L. (Leena Johanna); Peral, B. (Belén); Perola, M. (Markus); Psaty, B.M. (Bruce); Salomaa, V. (Veikko); Savage, D.B. (David); Semple, R.K. (Robert); Skaric-Juric, T. (Tatjana); Sigurdsson, G. (Gunnar); Spector, T.D. (Timothy); Syvänen, A.-C.; Talmud, P.J. (Philippa); Thorleifsson, G. (Gudmar); Thorsteinsdottir, U. (Unnur); Uitterlinden, A.G. (André); Tikka-Kleemola, P. (Päivi); Vidal-Puig, A. (Antonio); Wild, S.H. (Sarah); Wright, A.F. (Alan); Clegg, D.J. (Deborah); Schadt, E.E. (Eric); Wilson, J.F. (James); Rudan, I. (Igor); Ripatti, S. (Samuli); Borecki, I.B. (Ingrid); Shuldiner, A.R. (Alan); Ingelsson, E. (Erik); Jansson, J.O.; Kaplan, R.; Gudnason, V. (Vilmundur); Harris, T.B. (Tamara); Groop, L. (Leif); Kiel, D.P. (Douglas); Rivadeneira Ramirez, F. (Fernando); Walker, M. (Mark); Barroso, I. (Inês); Vollenweider, P. (Peter); Waeber, G. (Gérard); Chambers, J.C. (John); Kooner, J.S. (Jaspal); Soranzo, N. (Nicole); Hirschhorn, J.N. (Joel); Stefansson, K. (Kari); Wichmann, H.E. (Heinz Erich); Ohlsson, C. (Claes); O'Rahilly, S. (Stephen); Wareham, N.J. (Nicholas); Speliotes, E.K. (Elizabeth); Fox, C.S. (Caroline); Laakso, M. (Markku); Loos, R.J.F. (Ruth); Aulchenko, Y.S. (Yurii)
    In:Nature Genetics, 43(8), 753 - 760. ISSN 1061-4036.

    Abstract:

    Genome-wide association studies have identified 32 loci influencing body mass index, but this measure does not distinguish lean from fat mass. To identify adiposity loci, we meta-analyzed associations between ∼2.5 million SNPs and body fat percentage from 36,626 individuals and followed up the 14 mo

  • Maternal smoking during pregnancy and kidney volume in the offspring: the Generation R Study (2011)Open access

    Authors:Steegers, E.A.P.; Heijden, A.J. van der; Lequin, M.H.; Hofman, A.; Geelhoed, J.J.M.; Moll, H.A.; Taal, H.R.; Jaddoe, V.W.V.
    In:Pediatric Nephrology, 26(8), 1275 - 1283. ISSN 0931-041x.

    Abstract:

    An adverse fetal environment leads to smaller kidneys, with fewer nephrons, which might predispose an individual to the development of kidney disease and hypertension in adult life. In a prospective cohort study among 1,072 children followed from early fetal life onward, we examined whether maternal

  • Runs of homozygosity do not influence survival to old age (2011)Open access

    Authors:Kuningas, M. (Maris); McQuillan, R. (Ruth); Wilson, J.F. (James); Hofman, A. (Albert); Tikka-Kleemola, P. (Päivi); Uitterlinden, A.G. (André); Tiemeier, H. (Henning)
    In:PLoS ONE, 6(7). ISSN 1932-6203.

    Abstract:

    Runs of homozygosity (ROH) are extended tracts of adjacent homozygous single nucleotide polymorphisms (SNPs) that are more common in unrelated individuals than previously thought. It has been proposed that estimating ROH on a genome-wide level, by making use of the genome-wide single nucleotide poly

  • Genetic architecture of circulating lipid levels (2011)

    Authors:Demirkan, A. (Aye); Amin, N. (Najaf); Isaacs, A. (Aaron); Järvelin, M.R.; Whitfield, J.B. (John); Wichmann, H.E. (Heinz Erich); Kyvik, K.O. (Kirsten Ohm); Rudan, I. (Igor); Gieger, C. (Christian); Hicks, A.A. (Andrew); Johansson, A. (Åsa); Hottenga, J.J.; Smith, J.J. (Johannes); Wild, S.H. (Sarah); Pedersen, N.L. (Nancy); Willemsen, G.A.H.M. (Gonneke); Mangino, M. (Massimo); Hayward, C. (Caroline); Uitterlinden, A.G. (André); Hofman, A. (Albert); Witteman, J.C.M. (Jacqueline); Montgomery, G.W. (Grant); Pietilainen, K.H. (Kirsi Hannele); Rantanen, T. (Taina); Kaprio, J. (Jaakko); Döring, A. (Angela); Pramstaller, P.P. (Peter Paul); Gyllensten, U. (Ulf); Geus, de E.J.C. (Eco); Penninx, B.W.J.H. (Brenda); Wilson, J.F. (James); Rivadeneria, F. (Fernando); Magnusson, P.K. (Patrik); Boomsma, D.I. (Dorret); Spector, T.D. (Timothy); Campbell, H. (Harry); Hoehne, B. (Birgit); Martin, N.G. (Nicholas); Oostra, B.A. (Ben); McCarthy, M.I. (Mark); Peltonen-Palotie, L. (Leena); Aulchenko, Y.S. (Yurii); Visscher, P.M. (Peter); Ripatti, S. (Samuli); Janssens, A.C.J.W. (Cécile); Tikka-Kleemola, P. (Päivi)
    In:European Journal of Human Genetics, 19(7), 813 - 819. ISSN 1018-4813.

    Abstract:

    Serum concentrations of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TGs) and total cholesterol (TC) are important heritable risk factors for cardiovascular disease. Although genome-wide association studies (GWASs) of circulating lipid lev

  • Genome-wide association studies of cerebral white matter lesion burden (2011)

    Authors:Fornage, M. (Myriam); Debette, S. (Stéphanie); Bis, J.C. (Joshua); Schmidt, R. (Reinhold); Ikram, M.A. (Mohammed Arfan); Dufouil, C. (Carole); Sigurdsson, S. (Stefan); Lumley, T. (Thomas); DeStefano, A.L. (Anita); Fazekas, F. (Franz); Vrooman, H.A. (Henri); Shibata, D.K. (Dean); Maillard, P. (Pauline); Zijdenbos, A.P.; Smith, A.V. (Albert Vernon); Gudnason, H. (Haukur); Boer, de R. (Renske); Cushman, M. (Mary Ann); Mazoyer, B. (Bernard); Heiss, G. (Gerardo); Vernooij, M.W. (Meike); Enzinger, C. (Christian); Glazer, N.L. (Nicole); Beiser, A. (Alexa); Knopman, D.S. (David); Cavalieri, M. (Margherita); Niessen, W.J. (Wiro); Harris, T.B. (Tamara); Petrovic, K. (Katja); Lopez, O.L. (Oscar); Au, R. (Rhoda); Lambert, J.C. (Jean Charles); Hofman, A. (Albert); Gottesman, R.F. (Rebecca); Garcia, M. (Melissa); Heckbert, S.R. (Susan); Atwood, L.D. (Larry); Catellier, D.J. (Diane); Uitterlinden, A.G. (André); Yang, Q. (Qiong Fang); Aspelund, T. (Thor); Romero, J.R. (Jose Rafael); Rice, K. (Kenneth); Taylor, K.D. (Kent); Nalls, M.A. (Michael); Rotter, J.I. (Jerome); Sharrett, R. (Richey); Tikka-Kleemola, P. (Päivi); Amouyel, P. (Philippe); Wolf, P.A. (Philip); Lugt, van der A. (Aad); Boerwinkle, E. (Eric); Psaty, B.M. (Bruce); Seshadri, S. (Sudha); Tzourio, C. (Christophe); Breteler, M.M.B. (Monique); Mosley, T.H. (Thomas); Longstreth, W.T.; DeCarli, C. (Charles); Launer, L.J. (Lenore)
    In:Annals of Neurology, 69(6), 928 - 939. ISSN 0364-5134.

    Abstract:

    Objective: White matter hyperintensities (WMHs) detectable by magnetic resonance imaging are part of the spectrum of vascular injury associated with aging of the brain and are thought to reflect ischemic damage to the small deep cerebral vessels. WMHs are associated with an increased risk of cogniti

  • Prenatal and postnatal psychological symptoms of parents and family functioning: The impact on child emotional and behavioural problems (2011)

    Authors:Velders, F.P. (Fleur); Dieleman, G.C. (Gwen); Henrichs, J. (Jens); Jaddoe, V.W.V. (Vincent); Hofman, A. (Albert); Verhulst, F.C. (Frank); Hudziak, J.J. (James); Tiemeier, H. (Henning)
    In:European Child and Adolescent Psychiatry, 20(7), 341 - 350. ISSN 1018-8827.

    Abstract:

    Although relations of various parental psychological problems and family functioning with child development are well documented, it remains unclear whether specific prenatal or specific postnatal risk factors are independently associated with child emotional and behavioural problems, or whether obse

  • Chlamydia trachomatis infection during pregnancy associated with preterm delivery: A population-based prospective cohort study (2011)Open access

    Authors:Rours, G.I.J.G. (Ingrid); Dujits, L. (Liesbeth); Moll, H.A. (Henriëtte); Arends, L.R. (Lidia); Groot, de R. (Ronald); Jaddoe, V.W.V. (Vincent); Hofman, A. (Albert); Steegers-Theunissen, R.P.M. (Regine); Mackenbach, J.P. (Johan); Ott, A. (Alewijn); Willemse, H.F.; Zwaan, van der E.A.; Verkooijen, R.P. (Roel); Verbrugh, H.A. (Henri)
    In:European Journal of Epidemiology, 26(6), 493 - 502. ISSN 0393-2990.

    Abstract:

    Chlamydia trachomatis infection is the most prevalent bacterial sexually transmitted infection and may influence pregnancy outcome. This study was conducted to assess the effect of chlamydial infection during pregnancy on premature delivery and birthweight. Pregnant women attending a participating m

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