KNAW

Back to search results
Person

Dr. N.G.J. Jaspers

Pagina-navigatie:
filter results
Type
Date
Accessibility
Institution

1-10 out of 18 results by:date

Save search results

  • Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients (2010)Open access

    Authors:Ahmad, R.A. (Riris); Enzlin, J.H. (Jacqueline); Bhagwat, N. (Nikhil); Wijgers, N. (Nils); Raams, A. (Anja); Appledoorn, E. (Esther); Theil, A.F. (Arjan); Hoeijmakers, J.H.J. (Jan); Vermeulen, W. (Wim); Jaspers, N.G.J. (Nicolaas); Schärer, O.D. (Orlando); Niedernhofer, L.J. (Laura)
    In:P L o S Genetics (Print), 6(3). ISSN 1553-7390.

    Abstract:

    Xeroderma pigmentosum (XP) is caused by defects in the nucleotide excision repair (NER) pathway. NER removes helixdistorting DNA lesions, such as UV-induced photodimers, from the genome. Patients suffering from XP exhibit exquisite sun sensitivity, high incidence of skin cancer, and in some cases ne

  • A new type of radiosensitive T-B-NK+ severe combined immunodeficiency caused by a LIG4 mutation (2006)Open access

    Authors:Burg, van der M. (Mirjam); Zdzienicka, M.Z. (Malgorzata); Gent, van D.C. (Dik); Dongen, van J.J.M. (Jacques); Veelen, van L.R.; Verkaik, N.S. (Nicole); Wiegant, W.W. (Wouter); Hartwig, N.G. (Nico); Barendregt, B.H. (Barbara); Brugmans, L.J.L. (Linda); Raams, A. (Anja); Jaspers, N.G.J. (Nicolaas)
    In:Journal of Clinical Investigation. ISSN 0021-9738.

    Abstract:

    V(D)J recombination of Ig and TCR loci is a stepwise process during which site-specific DNA double-strand breaks (DSBs) are made by RAG1/RAG2, followed by DSB repair by nonhomologous end joining. Defects in V(D)J recombination result in SCID characterized by absence of mature B and

  • The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA insterstrand cross-link-induced double-strand breaks (2004)Open access

    Authors:Niedernhofer, L.J. (Laura); Odijk, H. (Hanny); Budzowska, M. (Magdalena); Drunen, van E. (Ellen); Maas, A. (Alex); Theil, A.F. (Arjan); Wit, de J. (Jan); Beverloo, H.B. (Berna); Hoeijmakers, J.H.J. (Jan); Jaspers, N.G.J. (Nicolaas); Kanaar, R. (Roland)
    In:Molecular and Cellular Biology, 13, 5776 - 5787. ISSN 0270-7306.

    Abstract:

    Interstrand cross-links (ICLs) are an extremely toxic class of DNA damage incurred during normal metabolism or cancer chemotherapy. ICLs covalently tether both strands of duplex DNA, preventing the strand unwinding that is essential for polymerase access. The mechanism of ICL repair in mammalian cel

  • Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways. (2002)Open access

    Authors:Raams, A. (Anja); Kelner, M.J. (Michael); Ng, J.M.Y. (Jessica); Yamashita, Y.M. (Yukiko); Takeda, S. (Shiunichi); McMorris, T.C. (Trevor); Hoeijmakers, J.H.J. (Jan); Jaspers, N.G.J. (Nicolaas)
    In:D N A Repair, 1(12), 1027 - 1038. ISSN 1568-7864.

    Abstract:

    Illudin S is a natural sesquiterpene drug with strong anti-tumour activity. Inside cells, unstable active metabolites of illudin cause the formation of as yet poorly characterised DNA lesions. In order to identify factors involved in their repair, we have performed a detailed genetic survey of repai

  • Molecular mechanism of nucleotide excision repair (1999)Open access

    Authors:Laat, de W.L. (Wouter); Hoeijmakers, J.H.J. (Jan); Jaspers, N.G.J. (Nicolaas)
    In:Genes & Development. ISSN 0890-9369.

  • Mapping of the interaction domains between human repair proteins ERCC1 and XPF. (1998)Open access

    Authors:Laat, de W.L. (Wouter); Sijbers, A.M. (Anneke); Odijk, H. (Hanny); Appeldoorn, E. (Esther); Jaspers, N.G.J. (Nicolaas); Hoeijmakers, J.H.J. (Jan)
    In:Nucleic Acids Research, 26(18), 4146 - 4152. ISSN 0305-1048.

    Abstract:

    ERCC1-XPF is a heterodimeric protein complexinvolved in nucleotide excision repair and recombinational processes. Like its homologous complex in Saccharomyces cerevisiae , Rad10-Rad1, it acts as a structure-specific DNA endonuclease, cleaving at duplex-single-stranded DNA junctions. In repair, ERCC1

  • DNA structural elements required for ERCC1-XPF endonuclease activity (1998)Open access

    Authors:Laat, de W.L. (Wouter); Appeldoorn, E. (Esther); Hoeijmakers, J.H.J. (Jan); Jaspers, N.G.J. (Nicolaas)
    In:Journal of Biological Chemistry. ISSN 0021-9258.

    Abstract:

    The heterodimeric complex ERCC1-XPF is a structure-specific endonuclease responsible for the 5' incision during mammalian nucleotide excision repair (NER). Additionally, ERCC1-XPF is thought to function in the repair of interstrand DNA cross-links and, by analogy to the homologous

  • DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repair (1998)Open access

    Authors:Laat, de W.L. (Wouter); Appeldoorn, E. (Esther); Sugasawa, K. (Kaoru); Weterings, E. (Eric); Hoeijmakers, J.H.J. (Jan); Jaspers, N.G.J. (Nicolaas)
    In:Genes & Development. ISSN 0890-9369.

    Abstract:

    The human single-stranded DNA-binding replication A protein (RPA) is involved in various DNA-processing events. By comparing the affinity of hRPA for artificial DNA hairpin structures with 3'- or 5'-protruding single-stranded arms, we found that hRPA binds ssDNA with a defined

  • Mapping of interaction domains between human repair proteins ERCC1 and XPF (1998)Open access

    Authors:Laat, de W.L. (Wouter); Sijbers, A.M. (Anneke); Odijk, H. (Hanny); Hoeijmakers, J.H.J. (Jan); Jaspers, N.G.J. (Nicolaas)
    In:Nucleic Acids Research. ISSN 0305-1048.

    Abstract:

    ERCC1-XPF is a heterodimeric protein complexinvolved in nucleotide excision repair and recombinational processes. Like its homologous complex in Saccharomyces cerevisiae , Rad10-Rad1, it acts as a structure-specific DNA endonuclease, cleaving at duplex-single-stranded DNA junctions

  • Mammalian nucleotide excision repair and syndromes. (1997)Open access

    Authors:Vermeulen, W. (Wim); Boer, de J. (Jan); Citterio, E. (Elisabetta); Gool, van A.J. (Alain); Horst, van der G.T.J. (Gijsbertus); Jaspers, N.G.J. (Nicolaas); Laat, de W.L. (Wouter); Sijbers, A.M. (Anneke); Spek, van der P.J. (Peter); Sugasawa, K. (Kaoru); Weeda, G. (Geert); Winkler, G.S. (Sebastiaan); Bootsma, D. (Dirk); Egly, J-M. (Jean-Marc); Hoeijmakers, J.H.J. (Jan)
    In:Biochemical Society Transactions, 25, 309 - 315. ISSN 0300-5127.

Pages:

previous
 < 1 2 > 

Go to page top
Go back to contents
Go back to site navigation