Prof.dr. A.P.N. Themmen

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Erasmus University Rotterdam (38)

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Unsaturated fatty acids prevent desensitization of the human growth hormone secretagogue receptor by blocking its internalization (2010)

Authors:	Delhanty, P.J.D. (Patric); Kerkwijk, A. (Anke); Huisman, M. (Martijn); Zande, van de B. (Bedette); Verhoef-Post, M. (Miriam); Gauna, C. (Carlotta); Hofland, L.J. (Leo); Themmen, A.P.N. (Axel); Lely, van der A.J. (Aart Jan)
In:	American Journal of Physiology: Endocrinology and Metabolism, 299(3). ISSN 0193-1849.

Abstract:

The composition of the plasma membrane affects the responsiveness of cells to metabolically important hormones such as insulin and vasoactive intestinal peptide. Ghrelin is a metabolically regulated hormone that activates the G protein-coupled receptor GH secretagogue receptor type 1a (GHSR) not onl

Gekend Talent (2009)Open access

Author: Themmen, A.P.N. (Axel)

Abstract:
Rede, in verkorte vorm uitgesproken ter gelegenheid van het aanvaarden van het ambt van bijzonder hoogleraar met als leeropdracht Experimentele endocrinologie en medisch onderwijs aan het Erasmus MC, faculteit van de Erasmus Universiteit Rotterdam op 11 mei 2009.

Author:	Themmen, A.P.N. (Axel)

Variants in the ACVR1 gene are associated with AMH levels in women with polycystic ovary syndrome (2009)

Authors:	Kevenaar, M.E. (Marlies); Themmen, A.P.N. (Axel); Kerkwijk, A. (Anke); Valkenburg, O.; Uitterlinden, A.G. (André); Jong, de F.H. (Frank); Laven, J.S.E. (Joop); Visser, J.A. (Jenny)
In:	Human Reproduction, 24(1), 241 - 249. ISSN 0268-1161.

Abstract:

BACKGROUND: Polycystic ovaries display an increased number of pre-antral and antral follicles compared with normal ovaries, suggesting that early and late follicle development are disturbed. The pathophysiology of this process is poorly understood. Since the transforming growth factor β family membe

Antral follicle count reliably predicts number of morphologically healthy oocytes and follicles in ovaries of young adult cattle (2008)

Authors:	Ireland, J.L.H.; Scheetz, D.; Jimenez-Krassel, F.; Themmen, A.P.N. (Axel); Ward, F.; Lonergan, P.; Smith, G.W.; Perez, G.I.; Evans, A.C.O.
In:	Biology of Reproduction, 79(6), 1219 - 1225. ISSN 0006-3363.

Abstract:

Methods to predict numbers of healthy oocytes in the ovaries of young adults could have important diagnostic relevance in family planning and animal agriculture. We have observed that peak antral follicle count (AFC) determined by serial ovarian ultrasonography during follicular waves is very highly

Asp330 and Tyr331 in the C-terminal cysteine-rich region of the luteinizing hormone receptor are key residues in hormone-induced receptor activation (2008)

Authors: Bruysters, M.W.P. (Martijn); Verhoef-Post, M. (Miriam); Themmen, A.P.N. (Axel)
In: Journal of Biological Chemistry, 283(38), 25821 - 25828. ISSN 0021-9258.

Abstract:
The luteinizing hormone (LH) receptor plays an essential role in male and female gonadal function. Together with the follicle-stimulating hormone (FSH) and thyroid stimulating hormone (TSH) receptors, the LH receptor forms the family of glycoprotein hormone receptors. All glycoprotein hormone recept

Authors:	Bruysters, M.W.P. (Martijn); Verhoef-Post, M. (Miriam); Themmen, A.P.N. (Axel)
In:	Journal of Biological Chemistry, 283(38), 25821 - 25828. ISSN 0021-9258.

A new LH receptor splice mutation responsible for male hypogonadism with subnormal sperm production in the propositus, and infertility with regular cycles in an affected sister (2008)

Authors:	Bruysters, M.W.P. (Martijn); Christin-Maitre, S. (Sophie); Verhoef-Post, M. (Miriam); Sultan, C.; Auger, J.; Faugeron, I.; Larue, L.; Lumbroso, S.; Themmen, A.P.N. (Axel); Bouchard, P.
In:	Human Reproduction, 23(8), 1917 - 1923. ISSN 0268-1161.

Abstract:

BACKGROUND: Inactivating LH receptor (LHR) mutations have been described so far in men as well as in women. Phenotypes in men have been variable with in nearly all cases impairment of sex differentiation or azoospermia. We report a milder reproductive phenotype both in a male patient and his sister.

The endocrine and follicular growth dynamics throughout the menstrual cycle in women with consistently or variably elevated early follicular phase FSH compared with controls (2008)

Authors:	Koning, de C.H.; McDonnell, J. (Joseph); Themmen, A.P.N. (Axel); Jong, de F.H. (Frank); Homburg, R.; Lambalk, C.B. (Cornelius)
In:	Human Reproduction, 23(6), 1416 - 1423. ISSN 0268-1161.

Abstract:

BACKGROUND: Elevated early follicular phase (EFP) FSH is frequently observed in subfertile patients. In these women, temporary normalization of FSH concentrations is known to occur. We studied the complete endocrine cycle profile of subfertile young women with elevated basal FSH compared with contro

Mutations in a novel, cryptic exon of the luteinizing hormone/chorionic gonadotropin receptor gene cause male pseudohermaphroditism (2008)

Authors: Simoni, M. (Manuela); Richter-Unruh, A.; Themmen, A.P.N. (Axel)
In: PLoS Medicine, 5(4), 669 - 679. ISSN 1549-1277.

Abstract:
Background: Male pseudohermaphroditism, or Leydig cell hypoplasia (LCH), is an autosomal recessive disorder in individuals with a 46,XY karyotype, characterized by a predominantly female phenotype, a blind-ending vagina, absence of breast development, primary amenorrhea, and the presence of testicul

Authors:	Simoni, M. (Manuela); Richter-Unruh, A.; Themmen, A.P.N. (Axel)
In:	PLoS Medicine, 5(4), 669 - 679. ISSN 1549-1277.

A functional anti-müllerian hormone gene polymorphism is associated with follicle number and androgen levels in polycystic ovary syndrome patients (2008)

Authors:	Kevenaar, M.E. (Marlies); Laven, J.S.E. (Joop); Lie Fong, S. (Sharon); Uitterlinden, A.G. (André); Jong, de F.H. (Frank); Themmen, A.P.N. (Axel); Visser, J.A. (Jenny)
In:	Journal of Clinical Endocrinology and Metabolism, 93(4), 1310 - 1316. ISSN 0021-972x.

Abstract:

Context: The common characteristic of polycystic ovary syndrome (PCOS) is a disturbance in the selection of the dominant follicle, resulting in anovulation. In PCOS women, serum anti-Müllerian hormone (AMH) levels are elevated. Because AMH decreases FSH sensitivity in mice, the elevated AMH levels m

Anti-müllerian hormone as a marker of ovarian function in women after chemotherapy and radiotherapy for haematological malignancies (2008)

Authors:	Lie Fong, S. (Sharon); Lugtenburg, P.J. (Pieternella); Schipper, I.; Themmen, A.P.N. (Axel); Jong, de F.H. (Frank); Sonneveld, P. (Pieter); Laven, J.S.E. (Joop)
In:	Human Reproduction, 23(3), 674 - 678. ISSN 0268-1161.

Abstract:

BACKGROUND: In female cancer survivors, the accelerated loss of primordial follicles as a result of gonadal damage may lead to premature ovarian failure (POF). However, the extent of the damage is unpredictable. Anti-Müllerian hormone (AMH) constitutes a sensitive marker of ovarian reserve. Serum AM

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