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Prof.dr. Th.J.M. Helmerhorst

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  • Afscheid van de uitstrijk? (2011)Open access

    Author:Helmerhorst, T.J.M. (Theo)

    Abstract:

    Afscheidsrede Prof. dr. Theo Helmerhorst Hoogleraar vrouwenziekten en verloskunde Erasmus MC Uitgesproken op 9 december 2011

  • Vaginal and (Uncommon) Cervical Cancers in the Netherlands, 1989-2003 (2010)

    Authors:Aa, van der Maaike A.; Helmerhorst, Th.J.M.; Siesling, Sabine; Riemersma, Sietske; Coebergh, Jan Willem W.
    In:International Journal of Gynecological Cancer, 20, 638 - 645. IGCS and ESGO. ISSN 1048-891x.

    Abstract:

    Background: The clinical and prognostic evaluation of cervical and vaginal tumors other than squamous cell and adenocarcinomas is hampered by the low incidence, and clinical and epidemiological studies on these uncommon tumors are scarce. Having close affinity with the pathology laboratories, the Ne

  • Clinical management of ovarian small-cell carcinoma of the hypercalcemic type: A proposal for conservative surgery in an advanced stage of disease (2009)Open access

    Authors:Dykgraaf, R.H.M.; Jong, de D. (Diederick); Veen, van M. (Mirjam); Ewing-Graham, P.C. (Patricia); Helmerhorst, T.J.M. (Theo); Burg, van der M. (Mirjam)
    In:International Journal of Gynecological Cancer, 19(3), 348 - 353. ISSN 1048-891x.

    Abstract:

    Ovarian small-cell carcinoma of the hypercalcemic type is a rare and highly malignant tumor. In two thirds of the patients, the tumor is associated with asymptomatic paraneoplastic hypercalcemia. The diagnosis may be impeded; the tumor must be distinguished from other tumors with similar features. T

  • Disturbed patterns of immunocompetent cells in usual-type vulvar intraepithelial neoplasia (2008)Open access

    Authors:Seters, van M. (Manon); Beckmann, I. (Ilse); Heijmans-Antonissen, C. (Claudia); Beurden, van M. (Marc); Ewing, P.C. (Patricia); Zijlstra, F.J. (Freek); Helmerhorst, T.J.M. (Theo); Kleinjan, A. (Alex)
    In:Cancer Research, 68(16), 6617 - 6622. ISSN 0008-5472.

    Abstract:

    Genital infection with human papillomavirus (HPV) is usually transient, as the immune system is capable of eliminating the virus. When immunity "fails" and the infection persists, vulvar intraepithelial neoplasia (VIN) may develop. In this study, we examined the distribution of inflammatory cells in

  • Treatment of vulvar intraepithelial neoplasia with topical imiquimod (2008)

    Authors:Seters, van M. (Manon); Beurden, van M. (Marc); Kate, ten F.J.W. (Fiebo); Beckmann, I. (Ilse); Ewing, P.C. (Patricia); Eijkemans, M.J.C. (René); Kagie, M.J. (Marjolein ); Meijer, C.J.M. (Chris J.M.); Aaronson, K. (Neil); Kleinjan, A. (Alex); Heijmans-Antonissen, C. (Claudia); Zijlstra, F.J. (Freek); Burger, M.P.M.; Helmerhorst, T.J.M. (Theo)
    In:New England Journal of Medicine, 358(14), 1465 - 1473. ISSN 0028-4793.

    Abstract:

    Background: Alternatives to surgery are needed for the treatment of vulvar intraepithelial neoplasia. We investigated the effectiveness of imiquimod 5% cream, a topical immuneresponse modulator, for the treatment of this condition. Methods: Fifty-two patients with grade 2 or 3 vulvar intraepithelial

  • A shift to a peripheral Th2-type cytokine pattern during the carcinogenesis of cervical cancer becomes manifest in CIN III lesions (2005)Open access

    Authors:Bais, A.G. (Aagje); Beckmann, I. (Ilse); Lindemans, J. (Jan); Ewing, P.C. (Patricia); Meijer, C.J.L.M. (Chris); Helmerhorst, T.J.M. (Theo); Snijders, P.J.L.M. (Pieter)
    In:Journal of Clinical Pathology: an international peer-reviewed journal for health professionals and researchers in clinical pathology. ISSN 0021-9746.

    Abstract:

    BACKGROUND: A shifted balance between T helper 1 (Th1)-type and Th2-type cytokines has been hypothesised in cervical dysplasia. AIMS: To evaluate possible deregulation of the cytokine network by estimating the expression of peripheral cytokines in different stages of cervical disea

  • Estrogen receptor polymorphism predicts the onset of natural and surgical menopause (1999)Open access

    Authors:Weel, A.E.A.M. (Angelique); Uitterlinden, A.G. (André); Westendorp, I.C.D. (Iris); Burger, H. (Huibert); Helmerhorst, T.J.M. (Theo); Pols, H.A.P. (Huibert); Leeuwen, van J.P.T.M. (Hans); Schuit, S.C.E. (Stephanie); Hofman, A. (Albert)
    In:Journal of Clinical Endocrinology and Metabolism. ISSN 0021-972x.

    Abstract:

    Age at menopause and risk of hysterectomy have strong genetic components, but the genes involved remain ill defined. We investigated whether genetic variation at the estrogen receptor (ER) gene contributes to the variability in the onset of menopause in 900 postmenopaus

  • Ieder het hare (1997)Open access

    Author:Helmerhorst, T.J.M. (Theo)

    Abstract:

    Rede, uitgesproken t.g.v. de aanvaarding van het ambt van gewoon Hoogleraar in de Verloskunde en Gynaecologie in het bijzonder de Gynaecologie in de Faculteit der Geneeskunde en Gezondheidswetenschappen van de Erasmus Universiteit Rotterdam op 10 oktober 1997

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