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Dr. R.A. de Man

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  • Trends in liver transplantation for primary biliary cirrhosis in the Netherlands 1988-2008 (2010)Open access

    Authors:Kuiper, E.M.M. (Edith); Hansen, B.E. (Bettina); Metselaar, H.J. (Herold); Man, de R.A. (Robert); Haagsma, E.B. (Els); Hoek, van B. (Bart); Buuren, van H.R. (Henk)
    In:B M C Gastroenterology, 10. ISSN 1471-230x.

    Abstract:

    Background: A decrease in the need for liver transplantations (LTX) in Primary Biliary Cirrhosis (PBC), possibly related to treatment with ursodeoxycholic acid (UDCA), has been reported in the USA and UK. The aim of this study was to assess LTX requirements in PBC over the past 20 years in the Nethe

  • Diagnosis and treatment of hepatocellular adenoma in the Netherlands: Similarities and differences (2010)Open access

    Authors:Aalten, van S.M. (Susanna); Terkivatan, T. (Türkan); Man, de R.A. (Robert); Windt, van der D.J. (Dirk); Kok, N.F.M. (Niels); Dwarkasing, R.S. (Roy); IJzermans, J.N.M. (Jan)
    In:Digestive Surgery, 27(1), 61 - 67. ISSN 0253-4886.

    Abstract:

    Background: The diagnosis of hepatocellular adenoma (HA) has a great impact on the lives of young women and may pose clinical dilemmas to the clinician since there are no standardized protocols to follow. We aimed to establish expert opinions on diagnosis and treatment of HA by collecting data from

  • Management of hepatocellular adenoma during pregnancy (2010)Open access

    Authors:Noels, J.E. (Johanna); Aalten, van S.M. (Susanna); Windt, van der D.J. (Dirk); Kok, N.F.M. (Niels); Man, de R.A. (Robert); Terkivatan, T. (Türkan); IJzermans, J.N.M. (Jan)
    In:Journal of Hepatology, 54(3), 553 - 558. ISSN 0168-8278.

    Abstract:

    Background & Aims: Hepatocellular adenoma in pregnant women requires special considerations because of the risk of hormone induced growth and rupture. To prevent these potential lethal complications, pregnancy is either often discouraged or the surgical resection of large adenomas is recommended. It

  • Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B (2008)

    Authors:Marcellin, P. (P.); Heathcote, E.J. (Jenny); Buti, M. (Maria); Gane, E. (Ed); Man, de R.A. (Robert); Krastev, Z. (Zahary); Germanidis, G. (George); Lee, S.S. (Sam ); Flisiak, R. (Robert); Kaita, K. (Kelly); Manns, M.P. (Michael); Kotzev, I. (Iskren); Tchernev, K. (Konstantin); Buggisch, P. (Peter); Weilert, F. (Frank); Kurdas, O.O. (Oya Ovung); Shiffman, M.L. (Mitchell); Trinh, H. (Huy); Washington, M.K. (Mary Kay); Sorbel, J. (Jeff); Anderson, J. (James); Snow-Lampart, A. (Andrea); Mondou, E. (Elsa); Quinn, J. (Joe); Rousseau, M.F. (Francois)
    In:New England Journal of Medicine, 359(23), 2442 - 2455. ISSN 0028-4793.

    Abstract:

    Background: Tenofovir disoproxil fumarate (DF) is a nucleotide analogue and a potent inhibitor of human immunodeficiency virus type 1 reverse transcriptase and hepatitis B virus (HBV) polymerase. Methods: In two double-blind, phase 3 studies, we randomly assigned patients with hepatitis B e antigen

  • Logistic feasibility of health related quality of life measurement in clinical practice: results of a prospective study in a large population of chronic liver patients (2008)Open access

    Authors:Gutteling, J.J. (Jolie); Busschbach, van J.J. (Jan); Man, de R.A. (Robert); Darlington, A-S.E. (Anne-Sophie)
    In:Health and Quality of Life Outcomes, 6(97), 1 - 9. ISSN 1477-7525.

    Abstract:

    Abstract<br/> BACKGROUND: The objective of the present study was to provide a complete and detailed report of technical and logistical feasibility problems with the implementation of routine computerized HRQoL measurement at a busy outpatient department of Hepatology that can serve as a tool for fut

  • Quality of health care and patient satisfaction in liver disease: The development and preliminary results of the QUOTE-Liver questionnaire (2008)Open access

    Authors:Gutteling, J.J. (Jolie); Man, de R.A. (Robert); Busschbach, van J.J. (Jan); Darlington, A.S.E.
    In:B M C Gastroenterology, 8. ISSN 1471-230x.

    Abstract:

    Background: Consensus on how to adequately measure patient satisfaction with health care is limited, and has led to the development of many questionnaires with various methodological problems. The objective of this study was to develop a liver disease- and care-specific patient satisfaction instrume

  • Somatostatin receptor in human hepatocellular carcinomas: Biological, patient and tumor characteristics (2008)Open access

    Authors:Verhoef, C. (Cornelis); Dekken, van H. (Herman); Hofland, L.J. (Leo); Zondervan, P.E. (Pieter); Wilt, de J.H.W. (Johannes); Marion, van R. (Ronald); Man, de R.A. (Robert); IJzermans, J.N.M. (Jan); Eijck, van C.H.J. (Casper)
    In:Digestive Surgery, 25(1), 21 - 26. ISSN 0253-4886.

    Abstract:

    Background/Aim: The evidence on the efficacy of somatostatin analogues in the treatment of hepatocellular carcinoma (HCC) in humans is conflicting. A variety of human tumors demonstrate somatostatin receptors. All subtypes bind human somatostatin with high affinity, while somatostatin analogues bind

  • Comparison of reverse hybridization, microarray, and sequence analysis for genotyping hepatitis B virus (2008)

    Authors:Pas, S.D. (Suzan); Tran, N. (Nathalie); Man, de R.A. (Robert); Burghoorn-Maas, C.; Vernet, G. (Guy); Niesters, H.G.M. (Bert)
    In:Journal of Clinical Microbiology, 46(4), 1268 - 1273. ISSN 0095-1137.

    Abstract:

    Hepatitis B virus (HBV) genotyping has become important in epidemiological and clinical diagnoses, given the relationship between the viral genotype and the progression of disease or the appearance of antiviral resistance. Since genotyping by sequence and phylogenetic analyses is not convenient in t

  • Effectiveness of health-related quality-of-life measurement in clinical practice: A prospective, randomized controlled trial in patients with chronic liver disease and their physicians (2008)Open access

    Authors:Gutteling, J.J. (Jolie); Darlington, A.S.E.; Janssen, H.L.A. (Harry); Duivenvoorden, H.J. (Hugo); Busschbach, van J.J. (Jan); Man, de R.A. (Robert)
    In:Quality of Life Research, 17(2), 195 - 205. ISSN 0962-9343.

    Abstract:

    Background: This study assessed the effectiveness of computerized measurement and feedback of health-related quality of life (HRQoL) in daily clinical practice in patients with chronic liver disease. Methods: One hundred and sixty-two patients (61% men; mean age 47.5 years) regularly completed compu

  • A prospective open study of the efficacy of high-dose recombinant hepatitis B rechallenge vaccination in HIV-infected patients (2008)

    Authors:Vriessluijs, de T.E.M.S. (Theodora); Hansen, B.E. (Bettina); Doornum, van G.J.J. (Gerard); Springeling, T. (Tirza); Evertsz, N.M. (Nicole); Man, de R.A. (Robert); Ende, van der M.E. (Marchina)
    In:The Journal of Infectious Diseases, 197(2), 292 - 294. ISSN 0022-1899.

    Abstract:

    Double-dose hepatitis B virus revaccination of human immunodeficiency virus (HIV)-infected patients proved to be effective in 50.7% of 144 patients who had previously failed to respond to standard doses. In the multivariate analysis, female patients were found to have a significantly better response

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