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Prof.dr. J.A.N. Verhaar

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  • Effect of arthritic synovial fluids on the expression of immunomodulatory factors by mesenchymal stem cells: An explorative in vitro study (2012)Open access

    Authors:Leijs, M.J.C.; Buul, G.M. van; Lubberts, E.W.; Bos, P.K.; Verhaar, J.A.N.; Hoogduijn, M.J.; Osch, G.J.V.M. van
    In:Frontiers in Immunology, 3(AUG), 1 - 7. ISSN 1664-3224.

    Abstract:

    Background:In diseased joints, the catabolic environment results in progressive joint damage. Mesenchymal stem cells (MSCs) can have immunomodulatory effects by secreting anti-inflammatory factors. To exert these effects, MSCs need to be triggered by proinflammatory cytokines. To explore the potenti

  • Systemic treatment with pulsed electromagnetic fields do not affect bone microarchitecture in osteoporotic rats (2012)Open access

    Authors:Jagt, O.P. van der; Linden, J.C. van der; Waarsing, J.H.; Verhaar, J.A.N.; Weinans, H.H.
    In:International Orthopaedics, 36(7), 1501 - 1506. ISSN 0341-2695.

    Abstract:

    Purpose: Pulsed electromagnetic fields (PEMF) are currently used in the treatment of spinal fusions and non-unions. There are indications that PEMF might also be effective in the treatment of osteoporosis. In this study we examined whether whole-body PEMF treatment affects the bone microarchitecture

  • Femoral revision surgery with impaction bone grafting (2012)Open access

    Authors:Have, B.L.E.F. ten; Brouwer, R.W.; Biezen, F.C. van; Verhaar, J.A.N.
    In:Journal of Bone and Joint Surgery: British Volume, 94 B(5), 615 - 618. ISSN 0301-620x.

    Abstract:

    The purpose of this prospective study was to evaluate the long-term clinical and radiological outcomes of revision of the femoral component of a total hip replacement using impaction bone grafting. Femoral revision with an impacted allograft was performed on 29 patients (31 hips). In all, 21 hips (6

  • A 5-year follow-up study of Alfredson's heel-drop exercise programme in chronic midportion Achilles tendinopathy (2012)Open access

    Authors:Plas, J.F.A.N. van der; Jonge, S. de; Vos, R-J. de; Heide, H.J.L. van der; Verhaar, J.A.N.; Weir, A.; Tol, J.L.
    In:British Journal of Sports Medicine: an international peer-reviewed journal of sport and exercise medicine, 46(3), 214 - 218. ISSN 0306-3674.

    Abstract:

    Background: Eccentric exercises have the most evidence in conservative treatment of midportion Achilles tendinopathy. Although short-term studies show significant improvement, little is known of the long-term (>3 years) results. Aim: To evaluate the 5-year outcome of patients with chronic midportion

  • Low-magnitude whole body vibration does not affect bone mass but does affect weight in ovariectomized rats (2012)Open access

    Authors:Jagt, O.P. van der; Linden, J.C. van der; Waarsing, J.H.; Verhaar, J.A.N.; Weinans, H.H.
    In:Journal of Bone and Mineral Metabolism, 30(1), 40 - 46. ISSN 0914-8779.

    Abstract:

    Mechanical loading has stimulating effects on bone architecture, which can potentially be used as a therapy for osteoporosis. We investigated the skeletal changes in the tibia of ovariectomized rats during treatment with whole body vibration (WBV). Different low-magnitude WBV treatment protocols wer

  • An osteochondral culture model to study mechanisms involved in articular cartilage repair (2012)Open access

    Authors:Vries-Van Melle, M.L. de; Mandl, E.W.; Kops, N.; Koevoet, W.; Verhaar, J.A.N.; Osch, G.J.V.M. van
    In:Tissue Engineering - Part C: Methods, 18(1), 45 - 53. ISSN 1937-3384.

    Abstract:

    Although several treatments for cartilage repair have been developed and used in clinical practice the last 20 years, little is known about the mechanisms that are involved in the formation of repair tissue after these treatments. Often, these treatments result in the formation of fibrocartilaginous

  • Trochanteric osteotomy versus posterolateral approach: Function the first year post surgery. A pilot study (2011)Open access

    Authors:Grinten, van der M.; Reijman, M. (Max); Biezen, van F.C. (Frans); Verhaar, J.A.N. (Jan)
    In:BMC Musculoskeletal Disorders, 12, 138 - 143. ISSN 1471-2474.

    Abstract:

    Background: Although no prospective studies have compared functional results of trochanteric osteotomy and a non-trochanteric approach, most surgeons feel that trochanteric osteotomy is outdated in simple hip arthroplasty. Reasons not to perform an osteotomy include the fear of longer rehabilitation

  • Clinically Translatable Cell Tracking and Quantification by MRI in Cartilage Repair Using Superparamagnetic Iron Oxides (2011)Open access

    Authors:Buul, van G.M. (Gerben); Koteg, G. (Gyula); Wielopolski, P.A. (Piotr); Farrell, E. (Eric); Bos, P.K. (Koen); Weinans, H.H. (Harrie); Grohnert, A.U. (Anja); Jahr, H. (Holger); Verhaar, J.A.N. (Jan); Krestin, G.P. (Gabriel); Osch, van G.J.V.M. (Gerjo); Bernsen, M.R. (Monique)
    In:PLoS ONE, 6(2), 1 - 9. ISSN 1932-6203.

    Abstract:

    Abstract BACKGROUND: Articular cartilage has very limited intrinsic regenerative capacity, making cell-based therapy a tempting approach for cartilage repair. Cell tracking can be a major step towards unraveling and improving the repair process of these therapies. We studied superparamagnetic iron

  • In-vivo generation of bone via endochondral ossification by in-vitro chondrogenic priming of adult human and rat mesenchymal stem cells (2011)Open access

    Authors:Farrell, E. (Eric); Both, S.K. (Sanne); Odörfer, K.I. (Kathrin); Koevoet, W. (Wendy); Kops, N. (Nic ole); O'Brien, F.J. (Fergal); Baatenburg de Jong, R.J. (Robert Jan); Verhaar, J.A.N. (Jan); Cuijpers, V. (Vincent); Jansen, J.A. (John); Erben, R.G. (Reinhold); Osch, van G.J.V.M. (Gerjo)
    In:BMC Musculoskeletal Disorders, 12(31), 1 - 9. ISSN 1471-2474.

    Abstract:

    Abstract Background: Bone grafts are required to repair large bone defects after tumour resection or large trauma. The availability of patients’ own bone tissue that can be used for these procedures is limited. Thus far bone tissue engineering has not lead to an implant which could be used as altern

  • Unfocused Extracorporeal Shock Waves Induce Anabolic Effects in Rat Bone (2011)Open access

    Authors:Jagt, van der O.P. (Olav); Piscaer, T.M. (Tom); Schaden, W. (Wolfgang); Li, J.; Kops, N. (Nic ole); Jahr, H. (Holger); Linden, van der J.C. (Jacqueline); Waarsing, J.H. (Jan); Verhaar, J.A.N. (Jan); Jong, de M. (Marion); Weinans, H.H. (Harrie)
    In:Journal of Bone and Joint Surgery: American Volume, 93(1), 38 - 48. ISSN 0021-9355.

    Abstract:

    Abstract. BACKGROUND: Extracorporeal shock waves are known to stimulate the differentiation of mesenchymal stem cells toward osteoprogenitors and induce the expression of osteogenic-related growth hormones. The aim of this study was to investigate if and how extracorporeal shock waves affected new b

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