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Prof.dr. R.Q. Hintzen

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  • Pregnancy in multiple sclerosis: clinical and self-report scales (2012)Open access

    Auteurs:Neuteboom, R.F.; Janssens, A.C.J.W.; Siepman, T.A.M.; Hoppenbrouwers, I.A.; Ketelslegers, I.A.; Jafari, N.; Steegers-Theunissen, R.P.M.; Groot, C.J.M. de; Hintzen, R.Q.; Erasmus MC: University Medical Center Rotterdam
    In:Journal of Neurology, Neurosurgery and Psychiatry: an international peer-reviewed journal for health professionals and researchers in all areas of neurology and neurosurgery, 259(2), 311 - 317. ISSN 0022-3050.

    Samenvatting:

    Relapse rate is decreased during pregnancy in multiple sclerosis (MS). Risk for postpartum relapse is increased in the first 3 months after delivery. We aimed to study clinical course of MS around pregnancy, using clinical as well as self-report scales, including data on quality of life (QoL), and t

  • Perspectives on the use of multiple sclerosis risk genes for prediction (2011)Open access

    Auteurs:Jafari, N. (Naghmeh); Broer, L. (Linda); Tikka-Kleemola, P. (Päivi); Janssens, A.C.J.W.; Hintzen, R.Q. (Rogier)
    In:PLoS ONE, 6(12). ISSN 1932-6203.

    Samenvatting:

    Objective: A recent collaborative genome-wide association study replicated a large number of susceptibility loci and identified novel loci. This increase in known multiple sclerosis (MS) risk genes raises questions about clinical applicability of genotyping. In an empirical set we assessed the predi

  • Proteomics comparison of cerebrospinal fluid of relapsing remitting and primary progressive multiple sclerosis (2010)Open access

    Auteurs:Stoop, M.P. (Marcel); Singh, V. (Vaibhav); Dekker, L.J.M. (Lennard); Titulaer, M.K. (Mark); Stingl, C. (Christoph); Burgers, P.C. (Peter); Sillevis Smitt, P.A.E. (Peter); Hintzen, R.Q. (Rogier); Luider, T.M. (Theo)
    In:PLoS ONE, 5(8), 1 - 8. ISSN 1932-6203.

    Samenvatting:

    Background: Based on clinical representation of disease symptoms multiple sclerosis (MScl) patients can be divided into two major subtypes; relapsing remitting (RR) MScl (85-90%) and primary progressive (PP) MScl (10-15%). Proteomics analysis of cerebrospinal fluid (CSF) has detected a number of pro

  • Quantitative proteomics and metabolomics analysis of normal human cerebrospinal fluid samples (2010)

    Auteurs:Stoop, M.P. (Marcel); Coulier, L. (Leon); Rosenling, T. (Therese); Shi, S. (Shanna); Smolinska, A. (Agnieszka); Buydens, L. (Lutgarde); Ampt, K.A.M. (Kirsten A.M.); Stingl, C. (Christoph); Dane, A. (Adrie); Muilwijk, B. (Bas); Luitwieler, R.L. (Ronald); Sillevis Smitt, P.A.E. (Peter); Hintzen, R.Q. (Rogier); Bischoff, R. (Rainer); Wijmenga, S.S. (Sybren S.); Hankemeier, T. (Thomas); Gool, van A.J. (Alain); Luider, T.M. (Theo)
    In:Molecular and Cellular Proteomics, 9(9), 2063 - 2075. ISSN 1535-9476.

    Samenvatting:

    The analysis of cerebrospinal fluid (CSF) is used in biomarker discovery studies for various neurodegenerative central nervous system (CNS) disorders. However, little is known about variation of CSF proteins and metabolites between patients without neurological disorders. A baseline for a large numb

  • Alles is mogelijk (2010)Open access

    Auteur:Hintzen, R.Q. (Rogier)

    Samenvatting:

    Rede, In verkorte vorm uitgesproken ter gelegenheid van het aanvaarden van het ambt van bijzonder hoogleraar met als leeropdracht Multiple Sclerose en Neuroimmunologie van het centrale zenuwstelsel aan het Erasmus MC, faculteit van de Erasmus Universiteit Rotterdam op 24 juni 2010

  • Retinal nerve fiber layer thickness in subgroups of multiple sclerosis, measured by optical coherence tomography and scanning laser polarimetry (2010)Open access

    Auteurs:Siepman, T.A.M. (Theodora); Wefers Bettink-Remeijer, M. (Marijke); Hintzen, R.Q. (Rogier)
    In:Journal of Neurology: official journal of the European Neurological Society, 1 - 7. ISSN 0340-5354.

    Samenvatting:

    Optical coherence tomography (OCT) and scanning laser polarimetry (GDx ECC) are non-invasive methods used to assess retinal nerve fiber layer (RNFL) thickness, which may be a reliable tool used to monitor axonal loss in multiple sclerosis (MS). The objectives of this study are (1) to compare OCT wit

  • Epstein Barr virus is not a characteristic feature in the central nervous system in established multiple sclerosis (2010)

    Auteurs:Peferoen, L.A.N. (Laura); Lamers, F. (Floris); Lodder, L.N.R. (Lenthe); Gerritsen, W. (Wouter); Huitinga, I. (Inge); Melief, M.J.; Giovannoni, G. (Gavin); Meier, U. (Ute); Hintzen, R.Q. (Rogier); Verjans, G.M.G.M. (George); Nierop, van G.P. (Gijsbert); Vos, W. (Wim); Peferoen-Baert, R.M.B. (Regina); Middeldorp, J.M. (Jaap); Valk, van der P. (Paul); Amor, S. (Sandra)
    In:Brain: a journal of neurology, 133(5). ISSN 0006-8950.

  • Epstein-Barr virus and disease activity in multiple sclerosis (2005)Open access

    Auteurs:Buljevac, D.; Flach, H.Z. (Zwenneke); Groen, J. (Jan); Doorn, van P.A. (Pieter); Meché, van der F.G.A.; Hintzen, R.Q. (Rogier); Hop, W.C.J. (Wim); Osterhaus, A.D.M.E. (Ab); Doornum, van G.J.J. (Gerard)
    In:Journal of Neurology, Neurosurgery and Psychiatry: an international peer-reviewed journal for health professionals and researchers in all areas of neurology and neurosurgery. ISSN 0022-3050.

    Samenvatting:

    OBJECTIVES: To study in relapsing-remitting (RR) multiple sclerosis (MS) whether exacerbations and brain activity as measured by magnetic resonance imaging (MRI) are associated with plasma levels of anti-Epstein Barr (EBV) antibodies and EBV DNA. METHODS: This was a prospective study with 73 RR MS p

  • Self reported stressful life events and exacerbations in multiple sclerosis: prospective study (2003)Open access

    Auteurs:Buljevac, D.; Hop, W.C.J. (Wim); Reedeker, W.; Janssens, A.C.J.W. (Cécile); Meché, van der F.G.A.; Doorn, van P.A. (Pieter); Hintzen, R.Q. (Rogier)
    In:BMJ British medical journal. ISSN 1468-5833.

    Samenvatting:

    OBJECTIVE: To study the relation between self reported stressful life events not related to multiple sclerosis and the occurrence of exacerbations in relapsing-remitting multiple sclerosis. DESIGN: Longitudinal, prospective cohort study. SETTING: Outpatient clinic of departme

  • Prospective study on the relationship between infections and multiple sclerosis exacerbations (2002)Open access

    Auteurs:Buljevac, D.; Flach, H.Z. (Zwenneke); Hop, W.C.J. (Wim); Hijdra, D.; Laman, J.D. (Jon); Savelkoul, H.F.J. (Huub); Meché, van der F.G.A.; Doorn, van P.A. (Pieter); Hintzen, R.Q. (Rogier)
    In:Brain: a journal of neurology. ISSN 0006-8950.

    Samenvatting:

    One of the characteristics of multiple sclerosis is the unpredictable occurrence of exacerbations and remissions. These fluctuations in disease activity are related to alterations in (auto-)immune activity. Exacerbations lead to short-term morbidity, but may also influence lo

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