Dr. T.L.M. ten Hagen

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Erasmus University Rotterdam (9)

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Hyperthermia and thermosensitive liposomes for improved delivery of chemotherapeutic drugs to solid tumors (2010)

Authors:	Koning, G.A. (Gerben); Eggermont, A.M.M. (Alexander); Lindner, L.H. (Lars); Hagen, ten T.L.M. (Timo)
In:	Pharmaceutical Research, 27(8), 1750 - 1754. ISSN 0724-8741.

Abstract:

Lipid-based nanocarriers or liposomes have been proven successful in the delivery of chemotherapeutic agents and are currently applied clinically in the treatment of various types of cancer. Liposomes offer the advantage of a high drug payload, decreased drug toxicity and enhanced drug accumulation

Local ATP generation by brain-type creatine kinase (CK-B) facilities cell motility (2009)Open access

Authors:	Kuiper, J.W.P. (Jan); Horssen, van R. (Remco); Oerlemans, F. (Frank); Peters, W. (Wilma); Dommelen, van M.M.T. (Michiel); Lindert, te M.M. (Mariska); Hagen, ten T.L.M. (Timo); Janssen, E. (Edwin); Fransen, J.A.M. (Jack); Wieringa, B. (Bé)
In:	PLoS ONE, 4(3). ISSN 1932-6203.

Abstract:

Background: Creatine Kinases (CK) catalyze the reversible transfer of high-energy phosphate groups between ATP and phosphocreatine, thereby playing a storage and distribution role in cellular energetics. Brain-type CK (CK-B) deficiency is coupled to loss of function in neural cell circuits, altered

Synergistic antitumor activity of histamine plus melphalan in isolated limb perfusion: preclinical studies. (2004)Open access

Authors:	Brunstein, F. (Flavia); Hoving, S. (Saske); Seynhaeve, A.L.B. (Ann); Tiel, van S.T. (Sandra); Guetens, G. (Gunther); Bruijn, de E.A. (Ernst); Eggermont, A.M.M. (Alexander); Hagen, ten T.L.M. (Timo)
In:	National Cancer Institute. Journal (Online), 96(21), 1603 - 1610. ISSN 1460-2105.

Abstract:

BACKGROUND: We have previously shown how tumor response of isolated limb perfusion (ILP) with melphalan was improved when tumor necrosis factor alpha (TNF-alpha) was added. Taking into account that other vasoactive drugs could also improve tumor response to ILP, we evaluated histam

Improved antitumor response to isolated limb perfusion with tumor necrosis factor after upregulation of endothelial monocyte-activating polypeptide II in soft tissue sarcoma (2002)Open access

Authors:	Lans, T.E.; Hagen, ten T.L.M. (Timo); Horssen, van R. (Remco); Wu, P.C.; Tiel, van S.T. (Sandra); Libutti, S.K.; Alexander, H.R.; Eggermont, A.M.M. (Alexander)
In:	Annals of Surgical Oncology. ISSN 1068-9265.

Abstract:

BACKGROUND: Experiments with tumor necrosis factor alpha (TNF) in rodents have shown that a high dose can lead to hemorrhagic necrosis in tumors. Endothelial monocyte-activating polypeptide II (EMAP-II) is a novel tumor-derived cytokine, and its expression increases the TNF-1 recep

Systemic toxicity and cytokine/acute phase protein levels in patients after isolated limb perfusion with tumor necrosis factor-alpha complicated by high leakage (2000)Open access

Authors: Stam, T.C.; Swaak, A.J.; Vries, de M.R. (Mark); Hagen, ten T.L.M. (Timo); Eggermont, A.M.M. (Alexander)
In: Annals of Surgical Oncology. ISSN 1068-9265.

Abstract:
BACKGROUND: Since the introduction of high-dose tumor necrosis factor-alpha (TNFalpha) in the setting of isolated limb perfusion (ILP) in the clinic, prevention of leakage to the body of the patient is monitored with great precision for fear of TNF-mediated toxicity. Th

Authors:	Stam, T.C.; Swaak, A.J.; Vries, de M.R. (Mark); Hagen, ten T.L.M. (Timo); Eggermont, A.M.M. (Alexander)
In:	Annals of Surgical Oncology. ISSN 1068-9265.

Isolated limb perfusion for local gene delivery: efficient and targeted adenovirus-mediated gene transfer into soft tissue sarcomas (2000)Open access

Authors:	Roos, de W.K.; Wilt, de J.H.W. (Johannes); Kaaden, van der M.E.; Manusama, E.R.; Vries, de M.W.; Bout, A.; Hagen, ten T.L.M. (Timo); Valerio, D.; Eggermont, A.M.M. (Alexander)
In:	Annals of Surgery. ISSN 0003-4932.

Abstract:

OBJECTIVE: To evaluate the potential of isolated limb perfusion (ILP) for efficient and tumor-specific adenovirus-mediated gene transfer in sarcoma-bearing rats. SUMMARY BACKGROUND DATA: A major concern in adenovirus-mediated gene therapy in cancer is the transfer of genes to

Involvement of T cells in enhanced resistance to Klebsiella pneumoniae septicemia in mice treated with liposome-encapsulated muramyl tripeptide phosphatidylethanolamine or gamma interferon (1998)Open access

Authors:	Hagen, ten T.L.M. (Timo); Vianen, van W. (Wim); Savelkoul, H.F.J. (Huub); Heremans, H.; Buurman, W.A.; Bakker-Woudenberg, I.A.J.M. (Irma)
In:	Infection and Immunity. ISSN 0019-9567.

Abstract:

We have previously shown that prophylactic administration of the liposome-encapsulated immunomodulating agents muramyl tripeptide phosphatidylethanolamine (MTPPE) and gamma interferon (IFN-gamma) results in strongly increased survival of mice from a normally lethal sept

Isolated hypoxic hepatic perfusion with tumor necrosis factor-alpha, melphalan, and mitomycin C using balloon catheter techniques: a pharmacokinetic study in pigs (1998)Open access

Authors:	IJken, van M.G.A. (Marc); Bruijn, de E.A. (Ernst); Boeck, de G. (Gert); Sijp, van der J.R. (Joost); Eggermont, A.M.M. (Alexander); Hagen, ten T.L.M. (Timo)
In:	Annals of Surgery. ISSN 0003-4932.

Abstract:

OBJECTIVE: To validate the methodology of isolated hypoxic hepatic perfusion (IHHP) using balloon catheter techniques and to gain insight into the distribution of tumor necrosis factor-alpha (TNF), melphalan, and mitomycin C (MMC) through the regional and systemic blood

Immunomodulation in gram-negative septicemia: liposome-encapsulated MTPPE and IFN-y in Klebsiella pneumoniae infection in mice, efficacy and mechanisms (1996)Open access

Author: Hagen, ten T.L.M. (Timo)