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Dr. T. den Heijer

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  • A 10-year follow-up of hippocampal volume on magnetic resonance imaging in early dementia and cognitive decline (2010)

    Authors:Heijer, den T. (Tom); Lijn, van der F. (Fedde); Koudstaal, P.J. (Peter); Hofman, A. (Albert); Lugt, van der A. (Aad); Krestin, G.P. (Gabriel); Niessen, W.J. (Wiro); Breteler, M.M.B. (Monique)
    In:Brain: a journal of neurology, 133(4), 1163 - 1172. ISSN 0006-8950.

    Abstract:

    Hippocampal atrophy is frequently observed on magnetic resonance images from patients with Alzheimer's disease and persons with mild cognitive impairment. Even in asymptomatic elderly, a small hippocampal volume on magnetic resonance imaging is a risk factor for developing Alzheimer's disease. Howev

  • Cerebral small-vessel disease and decline in information processing speed, executive function and memory (2005)Open access

    Authors:Prins, N.D. (Niels); Dijk, van E.J. (Ewoud); Heijer, den T. (Tom); Vermeer, S.E. (Sarah); Jolles, J. (Jellemer); Koudstaal, P.J. (Peter); Hofman, A. (Albert); Breteler, M.M.B. (Monique)
    In:Brain: a journal of neurology, 128(9), 2034 - 2041. ISSN 0006-8950.

    Abstract:

    Cerebral small-vessel disease is common in older people and may contribute to the development of dementia. The objective of the present study was to evaluate the relationship between measures of cerebral small-vessel disease on MRI and the rate of decline in specific cognitive domains in participant

  • Variations in estrogen receptor ? gene and risk of dementia, and brain volumes on MRI. (2004)Open access

    Authors:Schuit, S.C.E. (Stephanie); Hofman, A. (Albert); Koudstaal, P.J. (Peter); Duijn, van C.M. (Cock); Uitterlinden, A.G. (André); Pols, H.A.P. (Huibert); Breteler, M.M.B. (Monique); Meurs, van J.B.J. (Joyce); Heijer, den T. (Tom)
    In:Molecular Psychiatry, 9(12), 1129 - 1135. ISSN 1359-4184.

    Abstract:

    The role of estrogens in Alzheimer's disease (AD) is controversial. We investigated the association between well-recognized, and potentially functional, polymorphisms in the estrogen receptor (ER) gene and the risk of AD in a prospective study of 6056 Caucasian older men and women aged 55 years and

  • Alcohol intake in relation to brain magnetic resonance imaging findings in older persons without dementia (2004)Open access

    Authors:Heijer, den T. (Tom); Vermeer, S.E. (Sarah); Dijk, van E.J. (Ewoud); Prins, N.D. (Niels); Koudstaal, P.J. (Peter); Duijn, van C.M. (Cock); Breteler, M.M.B. (Monique); Hofman, A. (Albert)
    In:The American Journal of Clinical Nutrition. ISSN 0002-9165.

    Abstract:

    BACKGROUND: Consumers of light-to-moderate amounts of alcohol have a lower risk of dementia and, possibly, Alzheimer disease than do abstainers. Because vascular disease may contribute to symptoms of Alzheimer disease, reduction of cerebrovascular disease in consumers of light amounts of alcohol cou

  • Higher estrogen levels are not associated with larger hippocampi and better memory performance (2003)Open access

    Authors:Heijer, den T. (Tom); Geerlings, M.I. (Miriam); Jong, de F.H. (Frank); Launer, L.J. (Lenore); Pols, H.A.P. (Huibert); Breteler, M.M.B. (Monique); Hofman, A. (Albert)
    In:Archives of Neurology. ISSN 0003-9942.

    Abstract:

    BACKGROUND: Estrogens may prevent cognitive decline and Alzheimer disease. Animal study findings have shown beneficial effects of estrogen on the brain, particularly on the hippocampus, a structure related to memory performance and early Alzheimer disease. OBJECTIVE: To investigate

  • Homocysteine and brain atrophy on MRI of non-demented elderly (2003)Open access

    Authors:Heijer, den T. (Tom); Vermeer, S.E. (Sarah); Clarke, R.; Oudkerk, M. (Matthijs); Koudstaal, P.J. (Peter); Breteler, M.M.B. (Monique); Hofman, A. (Albert)
    In:Brain: a journal of neurology. ISSN 0006-8950.

    Abstract:

    Patients with Alzheimer's disease have higher plasma homocysteine levels than controls, but it is uncertain whether higher plasma homocysteine levels are involved in the early pathogenesis of the disease. Hippocampal, amygdalar and global brain atrophy on brain MRI have been propos

  • Silent brain infarcts and the risk of dementia and cognitive decline (2003)Open access

    Authors:Vermeer, S.E. (Sarah); Prins, N.D. (Niels); Heijer, den T. (Tom); Koudstaal, P.J. (Peter); Breteler, M.M.B. (Monique); Hofman, A. (Albert)
    In:New England Journal of Medicine. ISSN 0028-4793.

    Abstract:

    BACKGROUND: Silent brain infarcts are frequently seen on magnetic resonance imaging (MRI) in healthy elderly people and may be associated with dementia and cognitive decline. METHODS: We studied the association between silent brain infarcts and the risk of dementia and cognitive

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