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Dr. F. Rivadeneira Ramirez

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  • The Molecular Genetic Architecture of Self-Employment (2013)Open access

    Authors:Loos, M.J.H.M. van der; Rietveld, C.A.; Eklund, N.; Koellinger, Ph.D.; Rivadeneira Ramirez, F.; Abecasis, G.R.; Ankra-Badu, G.A.; Baumeister, S.E.; Benjamin, D.J.; Biffar, R.; Blankenberg, S.; Boomsma, D.I.; Cesarini, D.; Cucca, F.; Geus, E.J.C. de; Dedoussis, G.V.; Deloukas, P.; Dimitriou, M.; Eiriksdottir, G.; Eriksson, J.; Gieger, C.; Gudnason, V.; Höhne, B.; Holle, R.; Hottenga, J.J.; Isaacs, A.; Jarvelin, M.R.; Johannesson, M.; Kaakinen, M.; Kähönen, M.; Kanoni, S.; Laaksonen, M.A.; Lahti, J.; Launer, L.J.; Lehtimäki, T.; Loitfelder, M.; Magnusson, P.K.; Naitza, S.; Oostra, B.A.; Perola, M.; Petrovic, K.; Quaye, L.; Raitakari, O.; Ripatti, S.; Scheet, P.; Schlessinger, D.; Schmidt, C.O.; Senft, A.; Smith, A.V.; Spector, T.D.; Surakka, I.; Svento, R.; Terracciano, A.; Tikkanen, E.; Tikka-Kleemola, P.; Viikari, J.; Völzke, H.; Wichmann, H.E.; Wild, P.S.; Willems, S.M.; Willemsen, G.A.H.M.; Rooij, F.J.A. van; Groenen, P.J.F.; Uitterlinden, A.G.; Hofman, B.; Thurik, A.R.; Erasmus MC: University Medical Center Rotterdam
    In:PLoS ONE, 8(4), 1 - 15. ISSN 1932-6203.

    Abstract:

    Economic variables such as income, education, and occupation are known to affect mortality and morbidity, such as cardiovascular disease, and have also been shown to be partly heritable. However, very little is known about which genes influence economic variables, although these genes may have both

  • Genome-wide association and functional follow-up reveals new loci for kidney function (2012)Open access

    Authors:Pattaro, C. (Cristian); Köttgen, A. (Anna); Teumer, A. (Alexander); Böger, C.A. (Carsten); Fuchsberger, C. (Christian); Olden, M. (Matthias); Chen, M-H. (Ming-Huei); Li, M. (Man); Gao, X. (Xiaoyi); Gorski, M. (Mathias); Yang, Q. (Qiong Fang); O'Seaghdha, C.M. (Conall); Glazer, N.L. (Nicole); Isaacs, A. (Aaron); Liu, C.-T. (Ching-Ti); Smith, A.V. (Albert Vernon); O´Connell, J.R.; Struchalin, M.V. (Maksim); Tanaka, T. (Toshiko); Johnson, A.D. (Andrew); Feitosa, M.F. (Mary Furlan); Hwang, S.J.; Lohman, K. (Kurt); Cornelis, M. (Marilyn); Johansson, A. (Åsa); Tönjes, A. (Anke); Dehghan, A. (Abbas); Chouraki, V. (Vincent); Holliday, E.G. (Elizabeth); Sorice, R.; Kutalik, Z. (Zoltán); Lehtimäki, T. (Terho); Esko, T. (Tõnu); Ulivi, S. (Shelia); Trompet, S. (Stella); Imboden, M. (Medea); Kollerits, B. (Barbara); Pistis, G. (Giorgio); Harris, T.B. (Tamara); Launer, L.J. (Lenore); Aspelund, T. (Thor); Eiriksdottir, G. (Gudny); Mitchell, B.D. (Braxton); Boerwinkle, E. (Eric); Schmidt, R. (Reinhold); Cavalieri, M. (Margherita); Hu, F.B. (Frank); Demirkan, A. (Ayşe); Oostra, B.A. (Ben); Andrade, de M. (Mariza); Andrews, J.S. (Jeanette S.); Koenig, W. (Wolfgang); Illig, T. (Thomas); Döring, A. (Angela); Wichmann, H.E. (Erich); Kolcic, I. (Ivana); Zemunik, T. (Tatijana); Boban, M. (Mladen); Igl, W. (Wilmar); Zaboli, G. (Ghazal); Wild, S.H. (Sarah); Wright, A.F. (Alan); Campbell, H. (Harry); Biffar, R. (Reiner); Ernst, F.D.J. (Florian); Homuth, G. (Georg); Kroemer, H.K. (Heyo); Nauck, M. (Matthias); Kovacs, P. (Peter); Stumvoll, M. (Michael); Mägi, R. (Reedik); Hofman, A. (Albert); Uitterlinden, A.G. (André); Rivadeneira Ramirez, F. (Fernando); Aulchenko, Y.S. (Yurii); Polasek, O. (Ozren); Hastie, N. (Nick); Vitart, V. (Veronique); Wang, J.J. (Jie Jin); Bergmann, S. (Sven); Kähönen, M. (Mika); Viikari, J. (Jorma); Province, M.A. (Mike); Ketkar, S. (Shamika); Doney, A.S.F. (Alex); Ford, I. (Ian); Buckley, B.M. (Brendan M.); Paulweber, B. (Bernhard); Haun, M. (Margot); Sala, C. (Cinzia); Ciullo, M.; Vollenweider, P. (Peter); Raitakari, O. (Olli); Metspalu, A. (Andres); Palmer, C.N.A. (Colin); Gasparini, P. (Paolo); Jukema, J.W. (Jan Wouter); Kronenberg, F. (Florian); Toniolo, D. (Daniela); Gudnason, V. (Vilmundur); Shuldiner, A.R. (Alan); Coresh, J. (Josef); Ferrucci, L. (Luigi); Siscovick, D.S. (David); Tikka-Kleemola, P. (Päivi); Borecki, I.B. (Ingrid); Kardia, S.L.R. (Sharon); Curhan, G.C. (Gary); Rudan, I. (Igor); Gyllensten, U. (Ulf); Wilson, J.F. (James); Franke, A. (Andre); Pramstaller, P.P. (Peter Paul); Rettig, R. (Rainer); Prokopenko, I. (Inga); Witteman, J.C.M. (Jacqueline); Hayward, C. (Caroline); Ridker, P.M. (Paul); Parsa, A. (Afshin); Bochud, M. (Murielle); Heid, I.M. (Iris); Goessling, W. (Wolfram); Chasman, D.I. (Daniel); Kao, W.H.L. (Wen); Fox, C.S. (Caroline)
    In:PL o S Genetics (Online), 8(3). ISSN 1553-7404.

    Abstract:

    Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular

  • Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk (2011)Open access

    Authors:Ehret, G.B.; Munroe, P.; Rice, K.M.; Bochud, M.; Johnson, A.D.; Chasman, D.I.; Smith, A.V.; Tobin, M.D.; Verwoert, G.C.; Hwang, S.J.; Pihur, V.; Vollenweider, P.; O'Reilly, P.F.; Amin, N.; Bragg-Gresham, J.L.; Teumer, A.; Glazer, N.L.; Launer, L.J.; Hua Zhao, J.; Aulchenko, Y.S.; Heath, S.C.; Sõber, S.; Parsa, A.; Luan, J.; Arora, P.; Dehghan, A.; Zhang, F.; Lucas, G.; Hicks, A.A.; Jackson, A.U.; Peden, J.; Tanaka, T.; Wild, S.H.; Rudan, I.; Igl, W.; Milaneschi, Y.; Parker, A.N.; Fava, C.; Chambers, J.C.; Fox, E.R.; Kumari, M.; Jin Go, M.; Harst, P. van der; Hong Linda Kao, W.; Sjögren, M.; Vinay, D.G.; Alexander, M.; Tabara, Y.; Shaw-Hawkins, S.; Whincup, P.H.; Liu, Y.; Shi, G.; Kuusisto, J.; Tayo, B.; Seielstad, M.; Sim, X.; Hoang Nguyen, K.-D.; Lehtimäki, T.; Matullo, G.; Wu, Y.; Gaunt, T.R.; Charlotte Onland-Moret, N.; Cooper, M.N.; Platou, C.; Org, E.; Hardy, R.; Dahgam, S.; Palmen, J.; Vitart, V.; Braund, P.S.; Kuznetsova, T.; Uiterwaal, C.S.P.M.; Adeyemo, A.; Palmas, W.; Campbell, H.; Ludwig, B.; Tomaszewski, M.; Tzoulaki, I.; Palmer, N.D.; Aspelund, T.; Garcia, M.; Chang, Y.-P.C.; O´Connell, J.R.; Steinle, N.I.; Grobbee, D.E.; Arking, D.E.; Kardia, S.L.; Morrison, A.C.; Hernandez, D.G.; Najjar, S.S.; McArdle, W.L.; Hadley, D.; Brown, M.J.; Connell, J.; Hingorani, A.; Day, I.N.M.; Lawlor, D.A.; Beilby, J.P.; Lawrence, R.W.; Clarke, R.; Hopewell, J.; Ongen, H.; Dreisbach, A.W.; Li, Y.; Hunter Young, J.; Bis, J.C.; Kähönen, M.; Viikari, J.; Lee, N.R.; Chen, M-H.; Olden, M.; Pattaro, C.; Hoffman Bolton, J.A.; Köttgen, A.; Bergmann, S.; Mooser, V.; Chaturvedi, N.; Frayling, T.M.; Islam, M.; Jafar, T.H.; Erdmann, J.; Kulkarni, S.R.; Bornstein, S.R.; Gräßler, J.; Groop, L.; Voight, B.F.; Kettunen, J.; Howard, P.; Taylor, A.; Guarrera, S.; Ricceri, F.; Emilsson, V.; Plump, A.S.; Khaw, K-T.; Weder, A.B.; Hunt, S.C.; Sun, Y.V.; Bergman, R.N.; Collins, F.S.; Bonnycastle, L.L.; Scott, L.J.; Stringham, H.M.; Peltonen, L.; Perola, M.; Vartiainen, E.; Brand, S.-M.; Staessen, J.A.; Wang, Y.A.; Burton, P.R.; Soler Artigas, M.; Dong, Y.; Snieder, H.; Zhu, H.; Lohman, K.; Rudock, M.E.; Heckbert, S.R.; Wiggins, K.L.; Doumatey, A.; Shriner, D.; Veldre, G.; Viigimaa, M.; Kinra, S.; Prabhakaran, D.; Tripathy, V.; Langefeld, C.D.; Rosengren, A.; Thelle, D.S.; Maria Corsi, A.; Singleton, A.; Forrester, T.; Hilton, G.; McKenzie, C.A.; Salako, T.; Iwai, N.; Kita, Y.; Ogihara, T.; Ohkubo, T.; Okamura, T.; Ueshima, H.; Umemura, S.; Eyheramendy, S.; Meitinger, T.; Wichmann, H.E.; Shin Cho, Y.; Kim, H.-L.; Sehmi, J.S.; Hedblad, B.; Nilsson, P.; Davey-Smith, G.; Wong, A.; Narisu, N.; Stancáková, A.; Raffel, L.J.; Yao, J.; Kathiresan, S.; O'Donnell, C.J.; Schwartz, S.M.; Arfan Ikram, M.; Longstreth Jr, W.T.; Mosley, T.H.; Seshadri, S.; Shrine, N.R.G.; Wain, L.V.; Morken, M.A.; Swift, A.J.; Laitinen, J.; Prokopenko, I.; Zitting, P.; Humphries, S.E.; Danesh, J.; Rasheed, A.; Goel, A.; Hamsten, A.; Watkins, H.; Gilst, W.H. van; Janipalli, C.S.; Radha Mani, K.; Yajnik, C.; Hofman, A.; Mattace-Raso, F.U.S.; Oostra, B.A.; Demirkan, A.; Isaacs, A.; Rivadeneira Ramirez, F.; Lakatta, E.; Orrù, M.; Scuteri, A.; Ala-Korpela, M.; Kangas, A.J.; Lyytikäinen, L.-P.; Soininen, P.; Tukiainen, T.; Würtz, P.; Twee-Hee Ong, R.; Dörr, M.; Kroemer, H.K.; Völker, U.; Völzke, H.; Galan, P.; Hercberg, S.; Lathrop, G.M.; Zelenika, D.; Deloukas, P.; Mangino, M.; Spector, T.D.; Zhai, G.; Meschia, J.F.; Nalls, M.A.; Sharma, P.; Terzic, J.; Kranthi Kumar, M.V.; Denniff, M.; Zukowska-Szczechowska, E.; Wagenknecht, L.E.; Gerald R. Fowkes, F.; Charchar, F.J.; Schwarz, P.E.H.; Hayward, C.; Guo, X.; Rotimi, C.; Bots, M.L.; Samani, N.J.; Polasek, O.; Talmud, P.J.; Nyberg, F.; Kuh, D.; Laan, M.; Hveem, K.; Schouw, Y.T. van der; Casas, J.P.; Mohlke, K.L.; Vineis, P.; Raitakari, O.; Ganesh, S.K.; Shyong Tai, E.; Laakso, M.; Rao, D.C.; Harris, T.B.; Morris, R.W.; Dominiczak, A.; Kivimaki, M.; Marmot, M.; Miki, T.; Saleheen, D.; Chandak, G.R.; Coresh, J.; Navis, G.; Salomaa, V.; Han, B.-G.; Kooner, J.S.; Melander, O.; Ridker, P.M.; Bandinelli, S.; Gyllensten, U.; Wright, A.F.; Wilson, J.F.; Ferrucci, L.; Farrall, M.; Tuomilehto, J.; Pramstaller, P.P.; Elosua, R.; Soranzo, N.; Sijbrands, E.J.G.; Altshuler, D.; Loos, R.J.F.; Shuldiner, A.R.; Gieger, C.; Meneton, P.; Uitterlinden, A.G.; Wareham, N.J.; Gudnason, V.; Rotter, J.I.; Rettig, R.; Uda, M.; Strachan, D.P.; Witteman, J.C.M.; Hartikainen, A.L.; Beckmann, J.S.; Boerwinkle, E.; Vasan, R.S.; Boehnke, M.; Larson, M.G.; Järvelin, M.R.; Psaty, B.M.; Elliott, P.; Tikka-Kleemola, P.; Newton-Cheh, C.; Levy, D.; Caulfield, M.; Abecasis, G.R.; Adair, L.S.; Bakker, S.J.L.; Barroso, I.; Erasmus MC: University Medical Center Rotterdam
    In:Nature: international weekly journal of science, 478(7367), 103 - 109. ISSN 0028-0836.

    Abstract:

    Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140mmg Hg systolic blood pressure ≥90mmg Hg diastolic blood pressure). Even small increments in blood pressure are associated w

  • Candidate gene studies and the quest for the entrepreneurial gene (2011)Open access

    Authors:Loos, van der M.J.H.M. (Matthijs); Koellinger, Ph.D. (Philipp); Groenen, P.J.F. (Patrick); Rietveld, C.A. (Cornelius); Rivadeneira Ramirez, F. (Fernando); Rooij, van F.J.A. (Frank); Uitterlinden, A.G. (André); Hofman, A. (Albert); Thurik, A.R. (Roy)
    In:Small Business Economics: an entrepreneurship journal, 37(3), 269 - 275. ISSN 0921-898x.

    Abstract:

    Candidate gene studies of human behavior are gaining interest in economics and entrepreneurship research. Performing and interpreting these studies is not straightforward because the selection of candidates influences the interpretation of the results. As an example, Nicolaou et al. (Small Bus Econ

  • A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol (2011)Open access

    Authors:Surakka, I. (Ida); Isaacs, A. (Aaron); Karssen, L.C. (Lennart); Laurila, P.-P.P.; Middelberg, R.P.S. (Rita); Tikkanen, E. (Emmi); Ried, J.S. (Janina); Lamina, C. (Claudia); Mangino, M. (Massimo); Igl, W. (Wilmar); Hottenga, J.J.; Lagou, V. (Vasiliki); Harst, van der P. (Pim); Leach, I.M.; Esko, T. (Tõnu); Kutalik, Z. (Zoltán); Wainwright, N.W. (Nicholas); Struchalin, M.V. (Maksim); Sarin, A.-P.; Kangas, A.J. (Antti); Viikari, J. (Jorma); Perola, M. (Markus); Rantanen, T. (Taina); Petersen, A.K.; Soininen, P. (Pasi); Johansson, A. (Åsa); Soranzo, N. (Nicole); Heath, A.C. (Andrew); Papamarkou, T. (Theodore); Prokopenko, I. (Inga); Tönjes, A. (Anke); Kronenberg, F. (Florian); Döring, A. (Angela); Rivadeneira Ramirez, F. (Fernando); Montgomery, G.W. (Grant); Whitfield, J.B. (John); Kähönen, M. (Mika); Lehtimäki, T. (Terho); Freimer, N.B. (Nelson); Willemsen, G.A.H.M. (Gonneke); Geus, de E.J.C. (Eco); Palotie, A. (Aarno); Sandhu, M.S. (Manj); Waterworth, D. (Dawn); Metspalu, A. (Andres); Stumvoll, M. (Michael); Uitterlinden, A.G. (André); Jula, A. (Antti); Navis, G. (Gerjan); Wijmenga, C. (Cisca); Wolffenbuttel, B.H.R. (Bruce); Taskinen, M.-R.; Ala-Korpela, M. (Mika); Kaprio, J. (Jaakko); Kyvik, K.O. (Kirsten Ohm); Boomsma, D.I. (Dorret); Pedersen, N.L. (Nancy); Gyllensten, U. (Ulf); Wilson, J.F. (James); Rudan, I. (Igor); Campbell, H. (Harry); Pramstaller, P.P. (Peter Paul); Spector, T.D. (Timothy); Witteman, J.C.M. (Jacqueline); Eriksson, J.G. (Johan); Salomaa, V. (Veikko); Oostra, B.A. (Ben); Raitakari, O. (Olli); Wichmann, H.E. (Heinz Erich); Gieger, C. (Christian); Järvelin, M.R.; Martin, N.G. (Nicholas); Hofman, A. (Albert); McCarthy, M.I. (Mark); Aulchenko, Y.S. (Yurii); Peltonen, L. (Leena Johanna); Tikka-Kleemola, P. (Päivi); Ripatti, S. (Samuli)
    In:P L o S Genetics (Print), 7(10). ISSN 1553-7390.

    Abstract:

    Recent genome-wide association (GWA) studies described 95 loci controlling serum lipid levels. These common variants explain ~25% of the heritability of the phenotypes. To date, no unbiased screen for gene-environment interactions for circulating lipids has been reported. We screened for variants th

  • Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque (2011)

    Authors:Bis, J.C. (Joshua); Kavousi, M. (Maryam); Franceschini, N. (Nora); Isaacs, A. (Aaron); Abecasis, G.R. (Gonçalo); Schminke, U. (Ulf); Post, W.S. (Wendy S.); Smith, A.V. (Albert Vernon); Cupples, L.A. (Adrienne); Markus, H.S. (Hugh S.); Schmidt, R. (Reinhold); Huffman, J.E. (Jennifer); Lehtimäki, T. (Terho); Baumert, J. (Jens); Münzel, T. (Thomas); Heckbert, S.R. (Susan); Dehghan, A. (Abbas); North, K.E. (Kari); Oostra, B.A. (Ben); Bevan, S. (Steve); Stoegerer, E.M. (Eva Maria); Hayward, C. (Caroline); Raitakari, O. (Olli); Meisinger, C. (Christa); Schillert, A. (Arne); Sanna, S.; Völzke, H. (Henry); Cheng, Y.C. (Yu Ching); Thorsson, B. (Bolli); Fox, C.S. (Caroline); Rice, K. (Kenneth); Rivadeneira Ramirez, F. (Fernando); Nambi, V. (Vijay); Halperin, E. (Eran); Petrovic, K. (Katja); Peltonen, L. (Leena Johanna); Wichmann, H.E. (Heinz Erich); Schnabel, R.B. (Renate); Dörr, M. (Marcus); Parsa, A. (Afshin); Aspelund, T. (Thor); Demissie, S. (Serkalem); Kathiresan, S. (Sekar); Reilly, M.P. (Muredach); Taylor, K.D. (Kent); Uitterlinden, A.G. (André); Couper, D.J. (David); Sitzer, M. (Matthias); Kähönen, M. (Mika); Illig, T. (Thomas); Wild, P.S. (Philipp); Orrù, M. (Marco); Lüdemann, J. (Jan); Shuldiner, A.R. (Alan); Eiriksdottir, G. (Gudny); White, C.C. (Charles); Rotter, J.I. (Jerome); Hofman, A. (Albert); Seissler, J. (Jochen); Zeller, T. (Tanja); Usala, G.; Ernst, F.D.J. (Florian); Launer, L.J. (Lenore); D'Agostino, R.B. (Ralph); O'Leary, D.H. (Daniel H.); Ballantyne, C. (Christie); Thiery, J.P. (Joachim); Ziegler, A.; Lakatta, E. (Edward); Chilukoti, R.K. (Ravi Kumar); Harris, T.B. (Tamara); Wolf, P.A. (Philip); Psaty, B.M. (Bruce); Polak, J.F. (Joseph F.); Li, X. (Xiaohui); Rathmann, W. (Wolfgang); Uda, M.; Boerwinkle, E. (Eric); Klopp, N. (Norman); Wilson, J.F. (James); Viikari, J. (Jorma); Koenig, W. (Wolfgang); Blankenberg, S. (Stefan); Newman, A.B. (Anne); Witteman, J.C.M. (Jacqueline); Heiss, G. (Gerardo); Duijn, C.V.; Scuteri, A. (Angelo); Homuth, G. (Georg); Mitchell, B.D. (Braxton); Gudnason, V. (Vilmundur); O'Donnell, C.J. (Christopher)
    In:Nature Genetics, 43(10), 940. ISSN 1061-4036.

    Abstract:

    Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events. We conducted a meta-analysis of genome-wide association data in 31,211 participants of European ancestry fro

  • Genetic determinants of serum testosterone concentrations in men (2011)Open access

    Authors:Ohlsson, C. (Claes); Wallaschofski, H. (Henri); Lunetta, K.L. (Kathryn); Stolk, L. (Lisette); Perry, J.R.B. (John); Koster, A. (Annemarie); Petersen, A.K.; Eriksson, J. (Joel); Lehtimäki, T. (Terho); Huhtaniemi, I.T. (Ilpo); Hammond, G.L. (Geoffrey); Maggio, M. (Marcello); Coviello, A.D. (Andrea); Emas Study Group, ; Ferrucci, L. (Luigi); Heier, M. (Margit); Hofman, A. (Albert); Holliday, K.L. (Kate); Jansson, J.O.; Kähönen, M. (Mika); Karasik, D. (David); Karlsson, M.K. (Magnus); Kiel, D.P. (Douglas); Liu, Y. (Yongmei); Ljunggren, Ö.; Lorentzon, M. (Mattias); Lyytikäinen, L.-P.; Meitinger, T. (Thomas); Mellström, D. (Dan); Melzer, D. (David); Miljkovic, I. (Iva); Nauck, M. (Matthias); Nilsson, M. (Maria); Penninx, B.W.J.H. (Brenda); Pye, S.R. (Stephen); Vasan, R.S. (Ramachandran Srini); Reincke, M. (Martin); Rivadeneira Ramirez, F. (Fernando); Tajar, A. (Abdelouahid); Teumer, A. (Alexander); Uitterlinden, A.G. (André); Ulloor, J. (Jagadish); Viikari, J. (Jorma); Völker, U. (Uwe); Völzke, H. (Henry); Wichmann, H.E. (Heinz Erich); Wu, T.-S.; Zhuang, W.V.; Ziv, E. (Elad); Raitakari, O. (Olli); Bidlingmaier, M. (Martin); Harris, T.B. (Tamara); Murray, A. (Anna); Jong, de F.H. (Frank); Murabito, J. (Joanne); Bhasin, S. (Shalender); Vandenput, L. (Liesbeth); Haring, R. (Robin)
    In:P L o S Genetics (Print), 7(10). ISSN 1553-7390.

    Abstract:

    Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of serum testosterone's high heritability, we performed a meta-analysis of genome-wide association data in 8,938 men from seven cohorts

  • Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure (2011)Open access

    Authors:Wain, L.V.; Verwoert, G.C.; O'Reilly, P.F.; Shi, G.; Johnson, T.; Bochud, M.; Rice, K.; Henneman, P.; Smith, A.V.; Ehret, G.B.; Amin, N.; Larson, M.G.; Mooser, V.; Hadley, D.; Dörr, M.; Bis, J.C.; Aspelund, T.; Esko, T.; Janssens, A.C.J.W.; Zhao, J.H.; Heath, S.C.; Laan, M.; Fu, J.; Pistis, G.; Luan, J.; Lucas, G.; Pirastu, N.; Pichler, I.; Jackson, A.U.; Webster, R.J.; Zhang, F.F.; Peden, J.; Schmidt, R.; Tanaka, T.; Campbell, H.; Igl, W.; Milaneschi, Y.; Hottenga, J.J.; Vitart, V.; Chasman, D.I.; Trompet, S.; Bragg-Gresham, J.L.; Alizadeh, B.Z.; Chambers, J.C.; Guo, X.; Lehtimäki, T.; Kuhnel, B.; Lopez, L.M.; Polasek, O.; Boban, M.; Nelson, C.P.; Morrison, A.C.; Pihur, V.; Ganesh, S.K.; Hofman, A.; Kundu, S.; Mattace-Raso, F.U.S.; Rivadeneira Ramirez, F.; Sijbrands, E.J.G.; Uitterlinden, A.G.; Hwang, S.J.; Vasan, R.S.; Wang, Y.A.; Bergmann, S.; Vollenweider, P.; Waeber, G.; Laitinen, J.; Pouta, A.; Zitting, P.; McArdle, W.L.; Kroemer, H.K.; Völker, U.; Völzke, H.; Glazer, N.L.; Taylor, K.D.; Harris, T.B.; Alavere, H.; Haller, T.; Keis, A.; Tammesoo, M.L.; Aulchenko, Y.S.; Khaw, K-T.; Galan, P.; Hercberg, S.; Lathrop, G.M.; Eyheramendy, S.; Org, E.; Sõber, S.; Lu, X.; Nolte, I.M.; Penninx, B.W.J.H.; Corre, T.; Masciullo, C.; Sala, C.; Groop, L.; Voight, B.F.; Melander, O.; O'Donnell, C.J.; Salomaa, V.; D, A.P.; Fabretto, A.; Faletra, F.; Ulivi, S.; Del Greco M, F.; Facheris, M.F.; Collins, F.S.; Bergman, R.N.; Beilby, J.P.; Hung, J.; Musk, A.W.; Mangino, M.; Shin, S.Y.; Soranzo, N.; Watkins, H.; Goel, A.; Hamsten, A.; Gider, P.; Loitfelder, M.; Zeginigg, M.; Hernandez, D.G.; Najjar, S.S.; Navarro, P.; Wild, S.H.; Corsi, A.M.; Singleton, A.; Geus, E.J.C. de; Willemsen, G.A.H.M.; Parker, A.N.; Rose, L.M.; Buckley, B.M.; Stott, D.J.; Orrù, M.; Uda, M.; Klauw, M.M. van der; Li, X.; Scott, J.; Chen, Y.D.I.; Burke, G.L.; Kähönen, M.; Viikari, J.; Döring, A.; Meitinger, T.; Davis, G.S.; Starr, J.M.; Emilsson, V.; Plump, A.S.; Lindeman, J.H.; Hoen, P.A.C.T.; König, I.R.; Felix, J.F.; Clarke, R.; Hopewell, J.; Ongen, H.; Breteler, M.M.B.; Debette, S.; DeStefano, A.L.; Fornage, M.; Mitchell, G.F.; Holm, H.; Stefansson, K.; Thorleifsson, G.; Thorsteinsdottir, U.; Samani, N.J.; Preuss, M.; Rudan, I.; Hayward, C.; Deary, I.J.; Wichmann, H.E.; Raitakari, O.; Palmas, W.; Kooner, J.S.; Stolk, R.P.; Jukema, J.W.; Wright, A.F.; Boomsma, D.I.; Bandinelli, S.; Gyllensten, U.; Wilson, J.F.; Ferrucci, L.; Farrall, M.; Spector, T.D.; Palmer, L.J.; Tuomilehto, J.; Pfeufer, A.; Gasparini, P.; Siscovick, D.S.; Altshuler, D.; Loos, R.J.F.; Toniolo, D.; Snieder, H.; Gieger, C.; Meneton, P.; Wareham, N.J.; Oostra, B.A.; Metspalu, A.; Launer, L.J.; Rettig, R.; Strachan, D.P.; Beckmann, J.S.; Witteman, J.C.M.; Erdmann, J.; Willems van Dijk, J.A.P.; Boerwinkle, E.; Boehnke, M.; Ridker, P.M.; Järvelin, M.R.; Chakravarti, A.; Gudnason, V.; Newton-Cheh, C.; Levy, D.; Arora, P.; Munroe, P.; Psaty, B.M.; Caulfield, M.; Rao, D.C.; Elliott, P.; Tikka-Kleemola, P.; Abecasis, G.R.; Barroso, I.; Erasmus MC: University Medical Center Rotterdam
    In:Nature Genetics, 43(10), 1005 - 1012. ISSN 1061-4036.

    Abstract:

    Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we ident

  • Association of eGFR-related loci identified by GWAS with incident CKD and ESRD (2011)Open access

    Authors:Böger, C.A. (Carsten); Gorski, M. (Mathias); Li, M. (Man); Hoffmann, M.M. (Michael); Huang, C. (Chunmei); Yang, Q. (Qiong Fang); Teumer, A. (Alexander); Krane, V. (Vera); O'Seaghdha, C.M. (Conall); Kutalik, Z. (Zoltán); Wichmann, H.E. (Heinz Erich); Haak, T. (Thomas); Boes, E. (Eva); Coassin, S. (Stefan); Coresh, J. (Josef); Kollerits, B. (Barbara); Haun, M. (Margot); Paulweber, B. (Bernhard); Köttgen, A. (Anna); Shlipak, M.G. (Michael); Powe, N. (Neil); Hwang, S.J.; Dehghan, A. (Abbas); Rivadeneira Ramirez, F. (Fernando); Uitterlinden, A.G. (André); Hofman, A. (Albert); Beckmann, J.S. (Jacques); Krämer, B.K. (Bernhard); Witteman, J.C.M. (Jacqueline); Bochud, M. (Murielle); Siscovick, D.S. (David); Rettig, R. (Rainer); Kronenberg, F. (Florian); Wanner, C. (Christoph); Thadhani, R.I. (Ravi); Heid, I.M. (Iris); Fox, C.S. (Caroline); Kao, W.H.L. (Wen)
    In:P L o S Genetics (Print), 7(9). ISSN 1553-7390.

    Abstract:

    Family studies suggest a genetic component to the etiology of chronic kidney disease (CKD) and end stage renal disease (ESRD). Previously, we identified 16 loci for eGFR in genome-wide association studies, but the associations of these single nucleotide polymorphisms (SNPs) for incident CKD or ESRD

  • Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM (2011)

    Authors:Amin, N. (Najaf); Byrne, E.M. (Elaine); Johnson, J.L. (Joel L.); Chenevix-Trench, G. (Georgia); Walter, S. (Stefan); Nolte, I.M. (Ilja); Vink, J. (Jaap); Rawal, R. (R.); Mangino, M. (Massimo); Teumer, A. (Alexander); Keers, J.C. (J. C.); Verwoert, G.C. (Germaine); Baumeister, S. (S.); Biffar, R. (Reiner); Petersmann, A. (Astrid); Dahmen, N. (N.); Doering, A. (Angela); Isaacs, A. (Aaron); Broer, L. (Linda); Wray, N.R. (Naomi); Montgomery, G.W.; Levy, D. (Daniel); Psaty, B.M. (Bruce); Gudnason, V. (Vilmundur); Chakravarti, A. (Aravinda); Sulem, P. (Patrick); Gudbjartsson, D.F. (Daniel); Kiemeney, L.A. (Lambertus); Thorsteinsdottir, U. (Unnur); Stefansson, K. (Kari); Rooij, van F.J.A. (Frank); Aulchenko, Y.S. (Yurii); Hottenga, J.J.; Rivadeneira Ramirez, F. (Fernando); Hofman, B.; Uitterlinden, A.G. (André); Hammond, C.J. (Christopher); Shin, S.Y. (So Youn); Ikram, M.A. (Mohammed Arfan); Witteman, J.C.M. (Jacqueline); Janssens, A.C.J.W. (Cécile); Snieder, H. (Harold); Tiemeier, H. (Henning); Wolfenbuttel, B.H.R.; Oostra, B.A. (Ben); Heath, A.C.; Wichmann, E.; Spector, T.D. (Timothy); Grabe, H.J. (H. J.); Boomsma, D.I. (Dorret); Martin, N.G.; Duijn, van C.M. (Cock)
    In:Molecular Psychiatry. ISSN 1359-4184.

    Abstract:

    Coffee consumption is a model for addictive behavior. We performed a meta-analysis of genome-wide association studies (GWASs) on coffee intake from 8 Caucasian cohorts (N=18 176) and sought replication of our top findings in a further 7929 individuals. We also performed a gene expression analysis tr

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