Person

Prof.dr. J.H.M. Schellens

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Completed research projects

(the most recent research is at the top)
Researcher	Generation and validation of cytochrome P450 3A knockout and transgenic mice as tools for improveddrug development and research.
Project leader	Prediction of pharmacokinetic interactions between complementary, alternative medicines and (new) anticancer drugs
Project leader	Preclinical validation of chemical inhibitors of poly(ADP-ribose) polymerase (PARP) in conditional mouse models for BRCA-associated breast cancer
Project leader	Preclinical and clinical pharmacology of oral drugs
Project leader	Prevention and therapy of tumors
Project leader	mTHPC-mediated photodynamic therapy (PDT): how do drug uptake and distribution influence tumour and normal tissue response?
Project leader	Modulation of cytochrome P450 (CYP) and P-glycoprotein (P-gp) and BCR activity in gut wall and liver as major determinants of poor oral bioavailability of anticancer drugs: preclinical and clinical studies
Project leader	The use of novel pharmacodynamic end-points in early clinical trials: focus on farnesyltransferase inhibitors
Project leader	Compound Mrp2 (Abcc2) and other drug transporter knockout mice to study determinants of pharmacokinetics, toxicity risks and possible therapy optimization for anticancer drugs
Project leader	Mechanisms of reduced cellular accumulation of topoisomerase I inhibitors