Person

Dr. A.H. Schinkel

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Completed research projects

(the most recent research is at the top)
Project leader	Impact of the multidrug transporters p-glycoprot., MRP2 and BCRP on the behaviour of anti-cancer drugs
Project leader	Generation and validation of cytochrome P450 3A knockout and transgenic mice as tools for improved drug development and research
Project leader	Modulation of cytochrome P450 (CYP) and P-glycoprotein (P-gp) and BCR activity in gut wall and liver as major determinants of poor oral bioavailability of anticancer drugs: preclinical and clinical studies
Project leader	Compound Mrp2 (Abcc2) and other drug transporter knockout mice to study determinants of pharmacokinetics, toxicity risks and possible therapy optimization for anticancer drugs
Project leader	Physiological and pharmacological analysis of the novel multidrug resistance gene Bcrp (breast cancer resistance protein) using Brcp knockout mice
Project leader	Mechanisms of reduced cellular accumulation of topoisomerase I inhibitors