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Glomerular binding of anti-dsDNA autoantibodies: the dispute resolved? (2007)

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Title Glomerular binding of anti-dsDNA autoantibodies: the dispute resolved?
Published in Kidney International, Vol. 71, p.600-601. ISSN 0085-2538.
Author Bavel, C.C.A.W. van; Vlag, J. van der; Berden, J.H.M.
Date 2007
Type Article
Abstract The binding of anti-double-stranded DNA (anti-dsDNA) autoantibodies to the glomerular basement membrane (GBM) in lupus nephritis can be explained by two mechanisms: (1) direct crossreactive binding to intrinsic glomerular antigens; (2) nucleosome-mediated binding to heparan sulfate in the GBM. Kalaaji et al. demonstrated using novel techniques that glomerular in vivo-bound antoantibodies bind to nucleosomes/dsDNA derived from apoptotic cells and not to intrinsic glomerular structures.
Publication http://repository.ubn.ru.nl/handle/2066/51697
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Persistent Identifier urn:nbn:nl:ui:22-2066/51697
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Repository Radboud University Nijmegen

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