| Title | Glomerular binding of anti-dsDNA autoantibodies: the dispute resolved? |
|---|---|
| Published in | Kidney International, Vol. 71, p.600-601. ISSN 0085-2538. |
| Author | Bavel, C.C.A.W. van; Vlag, J. van der; Berden, J.H.M. |
| Date | 2007 |
| Type | article |
| Abstract | The binding of anti-double-stranded DNA (anti-dsDNA) autoantibodies to the glomerular basement membrane (GBM) in lupus nephritis can be explained by two mechanisms: (1) direct crossreactive binding to intrinsic glomerular antigens; (2) nucleosome-mediated binding to heparan sulfate in the GBM. Kalaaji et al. demonstrated using novel techniques that glomerular in vivo-bound antoantibodies bind to nucleosomes/dsDNA derived from apoptotic cells and not to intrinsic glomerular structures. |
| Publication | http://repository.ubn.ru.nl/handle/2066/51697 |
| OpenURL | Search this publication in (your) library |
| Persistent Identifier | urn:nbn:nl:ui:22-2066/51697 |
| Metadata | XML |
| Repository | Radboud University Nijmegen |
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