| Title | Thiazide diuretics and the risk for hip fracture |
|---|---|
| Published in | Annals of Internal Medicine. ISSN 0003-4819. |
| Author | Klift, van de M. (Marjolein); Laet, de C.E.D. (Chris); Herings, R.M. (Ron); Stijnen, Th. (Theo); Pols, H.A.P. (Huibert); Stricker, B.H.Ch. (Bruno); Schoofs, M.W.C.J. (Marlette); Hofman, A. (Albert) |
| Date | 2003-01-01 |
| Language | English |
| Type | article |
| Abstract | BACKGROUND: Since most hip fractures are related to osteoporosis, treating accelerated bone loss can be an important strategy to prevent hip fractures. Thiazides have been associated with reduced age-related bone loss by decreasing urinary calcium excretion. OBJECTIVE: To examine the association between dose and duration of thiazide diuretic use and the risk for hip fracture and to study the consequences of discontinuing use. DESIGN: Prospective population-based cohort study. SETTING: The Rotterdam Study. PARTICIPANTS: 7891 individuals 55 years of age and older. MEASUREMENTS: Hip fractures were reported by the general practitioners and verified by trained research assistants. Details of all dispensed drugs were available on a day-to-day basis. Exposure to thiazides was divided into 7 mutually exclusive categories: never use, current use for 1 to 42 days, current use for 43 to 365 days, current use for more than 365 days, discontinuation of use since 1 to 60 days, discontinuation of use since 61 to 120 days, and discontinuation of use since more than 120 days. RESULTS: 281 hip fractures occurred. Relative to nonuse, current use of thiazides for more than 365 days was statistically significantly associated with a lower risk for hip fracture (hazard ratio, 0.46 [95% CI, 0.21 to 0.96]). There was no clear dose dependency. This lower risk disappeared approximately 4 months after thiazide use was discontinued. CONCLUSIONS: Thiazide diuretics protect against hip fracture, but this protective effect disappears within 4 months after use is discontinued. |
| Publication | http://hdl.handle.net/1765/10223 |
| Persistent Identifier | urn:NBN:nl:ui:15-1765/10223 |
| Metadata | XML |
| Repository | Erasmus University Rotterdam |
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