| Title | Arterial oxygen saturation, COPD, and cerebral small vessel disease |
|---|---|
| Published in | Journal of Neurology, Neurosurgery and Psychiatry: an international peer-reviewed journal for health professionals and researchers in all areas of neurology and neurosurgery, Vol. 75, No. 5, p.733-736. ISSN 0022-3050. |
| Author | Dijk, van E.J. (Ewoud); Vermeer, S.E. (Sarah); Groot, de J.C. (Jan Cees); Minkelis, van de J.; Prins, N.D. (Niels); Oudkerk, M. (Matthijs); Hofman, A. (Albert); Koudstaal, P.J. (Peter); Breteler, M.M.B. (Monique) |
| Date | 2004-05-01 |
| Language | English |
| Type | article |
| Abstract | OBJECTIVE: To study whether lower arterial oxygen saturation (SaO(2)) and chronic obstructive pulmonary disease (COPD) are associated with cerebral white matter lesions and lacunar infarcts. METHODS: We measured SaO(2) twice with a pulse oximeter, assessed the presence of COPD, and performed MRI in 1077 non-demented people from a general population (aged 60-90 years). We rated periventricular white matter lesions (on a scale of 0-9) and approximated a total subcortical white matter lesion volume (range 0-29.5 ml). All analyses were adjusted for age and sex and additionally for hypertension, diabetes, body mass index, pack years smoked, cholesterol, haemoglobin, myocardial infarction, and left ventricular hypertrophy. RESULTS: Lower SaO(2) was independent of potential confounders associated with more severe periventricular white matter lesions (score increased by 0.12 per 1% decrease in SaO(2) (95% confidence interval 0.01 to 0.23)). Participants with COPD had more severe periventricular white matter lesions than those without (adjusted mean difference in score 0.70 (95% confidence interval 0.23 to 1.16)). Lower SaO(2) and COPD were not associated with subcortical white matter lesions or lacunar infarcts. CONCLUSION: Lower SaO(2) and COPD are associated with more severe periventricular white matter lesions. |
| Publication | http://hdl.handle.net/1765/22488 |
| Persistent Identifier | urn:NBN:nl:ui:15-1765/22488 |
| Metadata | XML |
| Repository | Erasmus University Rotterdam |
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