Diagnostic accuracy of 320-row multidetector computed tomography coronary angiography in the non-invasive evaluation of significant coronary artery disease
European Heart Journal, Vol. 31, No. 15, p.1908-1915. ISSN 0195-668x.
De Graaf, F.R. (Fleur R.); Schuijf, J.D. (Joanne); Velzen, van J.E. (Joella); Kroft, L.J. (Lucia); Roos, de A. (Albert); Reiber, J.H.C. (Johan); Boersma, H. (Eric); Schalij, M.J. (Martin Jan); Spanó, F. (Fabrizio); Jukema, J.W. (Jan Wouter); Wall, van der E.E. (Ernst); Bax, J.J. (Jeroen)
Aims Multidetector computed tomography coronary angiography (CTA) has emerged as a feasible imaging modality for non-invasive assessment of coronary artery disease (CAD). Recently, 320-row CTA systems were introduced, with 16 cm anatomical coverage, allowing image acquisition of the entire heart within a single heart beat. The aim of the present study was to assess the diagnostic accuracy of 320-row CTA in patients with known or suspected CAD. Methods and resultsA total of 64 patients (34 male, mean age 61 ± 16 years) underwent CTA and invasive coronary angiography. All CTA scans were evaluated for the presence of obstructive coronary stenosis by a blinded expert, and results were compared with quantitative coronary angiography. Four patients were excluded from initial analysis due to non-diagnostic image quality. Sensitivity, specificity, and positive and negative predictive values to detect ≥50 luminal narrowing on a patient basis were 100, 88, 92, and 100, respectively. Moreover, sensitivity, specificity, and positive and negative predictive values to detect ≥70 luminal narrowing on a patient basis were 94, 95, 88, and 98, respectively. With inclusion of non-diagnostic imaging studies, sensitivity, specificity, and positive and negative predictive values to detect ≥50 luminal narrowing on a patient basis were 100, 81, 88, and 100, respectively. Conclusion The current study shows that 320-row CTA allows accurate non-invasive assessment of significant CAD.