| Title | Agreement between maternal cannabis use during pregnancy according to self-report and urinalysis in a population-based cohort: The generation R study |
|---|---|
| Published in | European Addiction Research, Vol. 17, No. 1, p.37-43. ISSN 1022-6877. |
| Author | El Marroun, H. (Hanan); Tiemeier, H. (Henning); Jaddoe, V.W.V. (Vincent); Hofman, B.; Verhulst, F.C. (Frank); Brink, van den W. (Wim); Huizink, A.C. (Anja) |
| Date | 2010-12-01 |
| Language | English |
| Type | article |
| Abstract | Aim: To verify self-reported information on prenatal drug use in urine because reporting in pregnancy is sensitive to stigma and might lead to misclassification. Methods: Using semiquantitative immunochemical analysis, the presence of the urinary metabolite (11-nor-Δ9-tetrahydrocannabinol- 9-carboxylic acid) was compared to self-reported prenatal cannabis use. Sensitivity and specificity for self-report and urinalysis outcomes were calculated and Yule's Y was used as an agreement measure. Results: Urine samples were available for 3,997 pregnant women. Of these women, 92 reported having used cannabis during pregnancy (2.3%) and 71 had positive urine screens (1.8%). In total 35% of the 92 women with self-reported cannabis use also had a positive urine screen. Positive urines were relatively frequent in women reporting cannabis use before pregnancy only (7.6%) and in women with missing information (2.6%). Sensitivity and specificity of urinalysis compared to self-report were 0.46 and 0.98. Sensitivity and specificity of self-report compared to urinalysis were 0.36 and 0.99. Yule's Y amounted to 0.77, indicating substantial agreement between the measures. Conclusions: Our findings illustrate the difficulties in obtaining valid information on prenatal cannabis use. To improve the quality of cannabis use data, we suggest a 2-step approach starting with self-report. Copyright |
| Publication | http://hdl.handle.net/1765/28283 |
| Persistent Identifier | urn:NBN:nl:ui:15-1765/28283 |
| Metadata | XML |
| Repository | Erasmus University Rotterdam |
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