| Title | Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight |
|---|---|
| Published in | Nature Genetics, Vol. 42, No. 5, p.430-435. ISSN 1061-4036. |
| Author | Freathy, R.M. (Rachel); Mook-Kanamori, D.O. (Dennis); Sovio, U. (Ulla); Prokopenko, I. (Inga); Timpson, N. (Nicholas); Berry, D. (Diane); Warrington, N.; Widen, E. (Elisabeth); Hottenga, J.J.; Kaakinen, M. (Marika); Lange, L.A. (Leslie); Bradfield, J.P. (Jonathan); Kerkhof, M. (Marjan); Marsh, J.A. (Julie); Mägi, R. (Reedik); Chen, C.; Lyon, H.N. (Helen); Kirin, M. (Mirna); Adair, L.S. (Linda); Aulchenko, Y.S. (Yurii); Bennett, A.J. (Amanda); Borja, J.B. (Judith); Bouatia-Naji, N. (Nabila); Charoen, P. (Pimphen); Coin, L. (Lachlan); Cousminer, D.L. (Diana); Geus, de E.J.C. (Eco); Deloukas, P. (Panagiotis); Elliott, P. (Paul); Evans, D.M. (David); Froguel, P. (Philippe); Glaser, B. (Beate); Groves, C.J. (Christopher); Hartikainen, A.L.; Hassanali, N. (Neelam); Hirschhorn, J.N. (Joel); Hofman, A. (Albert); Holly, J.M.P. (Jeff); Hyppönen, E. (Elina); Kanoni, S. (Stavroula); Knight, B.A. (Bridget); Laitinen, J. (Jaana); Lindgren, C.M. (Cecilia); McArdle, W.L. (Wendy); O'Reilly, P.F. (Paul); Pennell, C.E. (Craig); Postma, D.S. (Dirkje); Pouta, A. (Anneli); Ramasamy, A. (Adaikalavan); Rayner, N.W. (N William); Ring, S.M. (Susan); Rivadeneira Ramirez, F. (Fernando); Shields, B.M. (Beverley); Strachan, D.P. (David); Surakka, I. (Ida); Taanila, A. (Anja); Tiesler, C. (Carla); Uitterlinden, A.G. (André); Tikka-Kleemola, P. (Päivi); Wijga, A. (Alet); Willemsen, G.A.H.M. (Gonneke); Zhang, H. (Haitao); Zhao, J.H.; Wilson, J.F. (James); Steegers-Theunissen, R.P.M. (Regine); Hattersley, A.T. (Andrew); Hagen, K. (Knut); Peltonen, L. (Leena Johanna); Mohlke, K.L. (Karen); Grant, S.F.; Hakonarson, H. (Hakon); Koppelman, G.H. (Gerard); Dedoussis, G.V. (George); Heinrich, J. (Joachim); Gillman, M.W. (Matthew W.); Palmer, C. (Cameron); Frayling, T.M. (Timothy); Boomsma, D.I. (Dorret); Smith, G.D.; Power, C. (Christopher); Jaddoe, V.W.V. (Vincent); Jarvelin, M.R.; McCarthy, M.I. (Mark) |
| Date | 2010-05-01 |
| Language | English |
| Type | article |
| Abstract | To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591). rs900400 near LEKR1 and CCNL1 (P = 2 × 10 35) and rs9883204 in ADCY5 (P = 7 × 10 15) were robustly associated with birth weight. Correlated SNPs in ADCY5 were recently implicated in regulation of glucose levels and susceptibility to type 2 diabetes, providing evidence that the well-described association between lower birth weight and subsequent type 2 diabetes has a genetic component, distinct from the proposed role of programming by maternal nutrition. Using data from both SNPs, we found that the 9% of Europeans carrying four birth weight-lowering alleles were, on average, 113g (95% CI 89-137g) lighter at birth than the 24% with zero or one alleles (P trend = 7 × 10 30). The impact on birth weight is similar to that of a mother smoking 4-5 cigarettes per day in the third trimester of pregnancy. |
| Publication | http://hdl.handle.net/1765/28299 |
| OpenURL | Search this publication in (your) library |
| Persistent Identifier | urn:NBN:nl:ui:15-1765/28299 |
| Metadata | XML |
| Repository | Erasmus University Rotterdam |
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