| Titel | Decreased DNA repair capacity in familial, but not in sporadic Alzheimer's disease |
|---|---|
| Gepubliceerd in | Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, Vol. 12, p.367-370. ISSN 0197-4580. |
| Auteur | Boerrigter, M.E.T.I.; Duijn, van C.M. (Cock); Mullaart, E.; Eikelenboom, P. (Piet); Togt, van der C.M.A.; Knook, D.L.; Vijg, J. (Jan); Hofman, A. (Albert) |
| Datum | 1991-01-01 |
| Trefwoord(en) | Male, Human, Support, Non-U.S. Gov't, Aged, Female, Middle Aged, DNA Damage, dementia, Aging/metabolism, 759-73-9 (Ethylnitrosourea), Alzheimer Disease/genetics/metabolism, DNA Repair/physiology, Ethylnitrosourea/diagnostic use, Lymphocytes/metabolism/physiology |
| Taal | Engels |
| Type | artikel |
| Samenvatting | Using the alkaline filter elution technique we determined the induction and disappearance of DNA single-strand breaks (SSB) in freshly isolated peripheral blood lymphocytes (PBL) from 43 Alzheimer's disease (AD) patients and 48 normal, healthy age- and sex-matched control subjects following in vitro exposure to N-ethyl-N-nitrosourea (ENU). The mean percentage SSB disappearance in PBL from control subjects at 1 h after ENU treatment was 41.4 +/- 2.9%; this was not significantly different from that found in samples from AD patients which had no (n = 16) or one (n = 12) first-degree relative with dementia (42.5 +/- 8.2% and 43.0 +/- 4.4%, respectively; p greater than 0.75). However, in PBL of 15 AD patients with at least two first-degree relatives with dementia the mean percentage SSB disappearance was 23.6 +/- 5.8%, which was significantly lower than that found in controls (p less than 0.01) or in the other AD patients (p less than 0.02). |
| Publicatie | http://hdl.handle.net/1765/5785 |
| Persistent Identifier | urn:NBN:nl:ui:15-1765/5785 |
| Metadata | XML |
| Repository | Erasmus Universiteit Rotterdam |
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