| Title | Genetic Risk of primary open-angle glaucoma. A population-based familial aggregation study |
|---|---|
| Published in | Archives of Ophthalmology, p.1640-1645. ISSN 0003-9950. |
| Author | Wolfs, R.C.W. (Roger); Klaver, C.C.W. (Caroline); Ramrattan, R.; Duijn, van C.M. (Cock); Hofman, A. (Albert); Jong, de P.T.V.M. (Paulus) |
| Date | 1998-01-01 |
| Language | English |
| Type | article |
| Abstract | OBJECTIVES: To study familial aggregation of primary open-angle glaucoma in a general population and to determine the absolute and relative risks for first-degree relatives. METHODS: First-degree relatives of patients with glaucoma (n = 48) and control subjects (n = 155) from the population-based Rotterdam Study underwent a standardized examination, including perimetry. MAIN OUTCOME MEASURES: Intraocular pressure, vertical cup-disc ratio; and the presence of glaucoma, defined as a visual field defect with a cup-disc ratio of 0.7 or higher or asymmetry of 0.3 or higher between both eyes. RESULTS: The prevalence of glaucoma was 10.4% in siblings of patients, 1.1% in offspring of patients, 0.7% in siblings of controls, and 0% in offspring of controls. Life-time risk of elevated intraocular pressure in relatives of patients vs relatives of controls was 42.5% vs 6.7%, of enlarged cup-disc ratio was 62.2% vs 16.6%, and of glaucoma was 22.0% vs 2.3%, yielding a risk ratio for glaucoma of 9.2 (95% confidence interval = 1.2-73.9). The population-attributable risk of glaucoma was 16.4%. CONCLUSIONS: In a general population, relatives of patients with glaucoma have a strongly increased risk of glaucoma. Enlarged cup-disc ratio, not intraocular pressure, was the earliest and most prominent feature of familial aggregation. Further studies are needed to disentangle the genetic components of the increased familial risk. |
| Publication | http://hdl.handle.net/1765/5919 |
| OpenURL | Search this publication in (your) library |
| Persistent Identifier | urn:NBN:nl:ui:15-1765/5919 |
| Metadata | XML |
| Repository | Erasmus University Rotterdam |
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