| Title | A genome-wide search for genes involved in type 2 diabetes in a recently genetically isolated population from the Netherlands |
|---|---|
| Published in | Diabetes, Vol. 52, No. 12, p.3001-3004. ISSN 0012-1797. |
| Author | Aulchenko, Y.S. (Yurii); Vaessen, N. (Norbert); Heutink, P. (Peter); Pullen, J. (Jan); Snijders, P.J.L.M. (Pieter); Hofman, A. (Albert); Sandkuijl, L.A. (Lodewijk); Houwing-Duistermaat, J.J. (Jeanine); Bennett, S. (Simon); Oostra, B.A. (Ben); Duijn, van C.M. (Cock); Edwards, M. (Mark) |
| Date | 2003-12-01 |
| Language | English |
| Type | article |
| Abstract | Multiple genes, interacting with the environment, contribute to the susceptibility to type 2 diabetes. We performed a genome-wide search to localize type 2 diabetes susceptibility genes in a recently genetically isolated population in the Netherlands. We identified 79 nuclear families with type 2 diabetes who were related within 13 generations and performed a 770-marker genome-wide scan search for shared founder alleles. Twenty-six markers yielded a logarithm of odds (LOD) score >0.59 (nominal P < 0.05), of which 7 reached LOD scores >1.17 (nominal P < 0.01). The strongest evidence for a type 2 diabetes locus was at marker D18S63 on chromosome 18p (LOD 2.3, P = 0.0006). This region was investigated further using additional markers. For one of these markers (D18S1105), we found a significant association with type 2 diabetes (odds ratio 6.7 [95% CI 1.5-30.7], P = 0.005 for the 97-bp allele, assuming a dominant model), which increased when limiting the analysis to patients with high BMI (12.25 [2.1-71], P = 0.003). A locus on chromosome 18p in patients with high BMI was suggested earlier by Parker et al. Our study is the first to confirm this locus. |
| Publication | http://hdl.handle.net/1765/5939 |
| Persistent Identifier | urn:NBN:nl:ui:15-1765/5939 |
| Metadata | XML |
| Repository | Erasmus University Rotterdam |
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