Dermatophagoides farinae-specific immunotherapy in atopic dogs with hypersensitivity to multiple allergens: A randomised, double blind, placebo-controlled study
The Veterinary Journal, Vol. 180, p.337-342. ISSN 1532-2971.
Willemse, T.; Bardagi, M.; Carlotti, D.; Ferrer, L.; Fondati, A.; Fontaine, J.; Leistra, M.; Noli, C.; Ordeix, L.; Scarampella, F.; Schleifer, S.; Sinke, J.; Roosje, P.
A randomised, placebo-controlled, double blind study was conducted on 25 dogs that had atopic dermatitis, together with skin test
reactivity and elevated serum IgE to Dermatophagoides farinae (Df) and at least one additional allergen. Dogs were treated with either a
Df-restricted immunotherapy solution (n = 14) or a placebo (n = 11) and evaluated 6 weeks and 3, 5, 7 and 9 months after the initiation
of treatment using a clinical scoring system (SASSAD) and pruritus analogue scale scores. The Df-restricted solution and the placebo
had an equal effect on both pruritus and the skin manifestations (P > 0.05). The results of this study indicate that in dogs with atopic
dermatitis based on hypersensitivity to environmental allergens in addition to D. farinae, Df-restricted immunotherapy is insufficient to
control the disease. Consequently, a solution for allergen-specific immunotherapy should remain customised.
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