Transmission of highly pathogenic avian influenza H5N1 virus... (2008)

Title Transmission of highly pathogenic avian influenza H5N1 virus in Pekin ducks is significantly reduced by a genetically distant H5N2 vaccine
Published in Virology, Vol. 382, No. 1, p.91-97. ISSN 0042-6822.
Author Goot, van der J.A.; Boven, van M.; Stegeman, A.; Water, van de S.G.P.; Jong, de M.C.M.; Koch, G.
Date 2008
Reference(s) Leerstoelgroep Kwantitatieve veterinaire epidemiologie, ASG Infectieziekten, CVI - Divisie Virologie, Extern overig, Quantitative Veterinary Epidemiology, ASG Infectieziekten, CVI - Division Virology, Extern other
Language English
Type Article
Abstract Domestic ducks play an important role in the epidemiology of H5N1 avian influenza. Although it is known that vaccines that have a high homology with the challenge virus are able to prevent infection in ducks, little is yet known about the ability of genetically more distant vaccines in preventing infection, disease, and transmission. Here we study the effect of a widely used H5N2 vaccine (A/Chicken/Mexico/232/94/CPA) on the transmission of H5N1 virus (A/Chicken/China/1204/04) in ducks. The quantitative analyses show that despite the low level of homology between the virus and vaccine strain transmission was significantly reduced two weeks after a single or double vaccination. Mortality and disease rates were reduced markedly already one week after a single vaccination.
Persistent Identifier urn:nbn:nl:ui:32-371491
Metadata XML
Source Wageningen University & Research Centre

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