Biochemie, Laboratorium voor Organische chemie, Laboratorium voor Fysische chemie en kolloïdkunde, Biochemistry, Laboratory for Organic Chemistry, Physical Chemistry and Colloid Science
Stabilized fluorescent polymeric micelles were made that are spontaneously taken up into the cytoplasm of human cells. The mobility of these micelles in living cells was probed on a molecular level for the first time with FCS. Importantly, the present micelles do not interact with proteins, membranes or cellular organelles. This system provides a new nanotechnological tool which is biocompatible, versatile and easy to use, especially since after further chemical modification, they could be targeted to specific subcellular locations.