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Long-term outcomes of eye-conserving treatment with Ruthenium(106)... (2010)

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Titel Long-term outcomes of eye-conserving treatment with Ruthenium(106) brachytherapy for choroidal melanoma.
Gepubliceerd in Radiotherapy and Oncology, Vol. 95, p.332-338. ISSN 0167-8140.
Auteur Verschueren, K.M.; Creutzberg, C.L.; Schalij-Delfos, N.E.; Ketelaars, M.; Klijsen, F.L.; Haeseker, B.I.; Ligtenberg, S.M.; Keunen, J.E.E.; Marijnen, C.A.
Datum 2010
Type Artikel
Samenvatting PURPOSE: To evaluate long-term outcomes of eye-conserving treatment using Ruthenium-106 plaque brachytherapy with or without transpupillary thermotherapy (TTT) for small to intermediate size choroidal melanomas. METHODS: Outcomes of 425 consecutive patients were analysed. The median basal tumour diameter was 10.9 mm (range 4.8-15.9 mm), and the median apical height 4.2 mm (range 1.2-9.3 mm). Brachytherapy doses ranged from 400 to 600Gy with TTT (86%), or from 600 to 800Gy without TTT (14%), specified at the scleral surface. Kaplan-Meier survival curves, log-rank tests and Cox regression analysis were used for analysis. RESULTS: Median follow-up was 50 months. Five-year actuarial local control was 96%. Five-year overall and metastases-free survival rates were 79.6% and 76.5%. Prognostic factors for metastasis-free survival were peripheral location (p=0.02) and smaller basal diameter (p<0.001). No dose effect relationships were found. Radiation side effects were frequent, with 2- and 5-year rates free of radiation complications of 60% and 35%. Five-year enucleation rate was 4.4% (10 for local recurrence, 7 for complications). Cosmetic and functional (visual acuity >0.10) eye preservation rates were 96% and 52% at 5 years. CONCLUSIONS: Ruthenium-106 brachytherapy for choroidal melanoma provides excellent rates of local control and eye preservation.
Publicatie http://repository.ubn.ru.nl/handle/2066/87287
OpenURL Zoek deze publicatie in (uw) bibliotheek
Persistent Identifier urn:nbn:nl:ui:22-2066/87287
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Repository Radboud Universiteit Nijmegen

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