| Title | Clinical, angiographic, and procedural predictors of angiographic restenosis after sirolimus-eluting stent implantation in complex patients |
|---|---|
| Published in | Circulation (Baltimore), Vol. 109, No. 11, p.1366-1370. ISSN 0009-7322. |
| Author | Lemos, P.A. (Pedro); Hoye, A. (Angela); Goedhart, D. (Dick); Arampatzis, C.A. (Chourmouzios); Saia, F. (Francesco); Giessen, van der W.J. (Wim); McFadden, E.P. (Eugene); Sianos, G. (Georgios); Smits, P.C. (Pieter); Hofma, S.H. (Sjoerd); Feyter, de P.J. (Pim); Domburg, van R.T. (Ron); Serruys, P.W.J.C. (Patrick) |
| Date | 2004-03-23 |
| Language | English |
| Type | article |
| Abstract | BACKGROUND: The factors associated with the occurrence of restenosis after sirolimus-eluting stent (SES) implantation in complex cases are currently unknown. METHODS AND RESULTS: A cohort of consecutive complex patients treated with SES implantation was selected according to the following criteria: (1) treatment of acute myocardial infarction, (2) treatment of in-stent restenosis, (3) 2.25-mm diameter SES, (4) left main coronary stenting, (5) chronic total occlusion, (6) stented segment >36 mm, and (7) bifurcation stenting. The present study population was composed of 238 patients (441 lesions) for whom 6-month angiographic follow-up data were obtained (70% of eligible patients). Significant clinical, angiographic, and procedural predictors of post-SES restenosis were evaluated. Binary in-segment restenosis was diagnosed in 7.9% of lesions (6.3% in-stent, 0.9% at the proximal edge, 0.7% at the distal edge). The following characteristics were identified as independent multivariate predictors: treatment of in-stent restenosis (OR 4.16, 95% CI 1.63 to 11.01; P<0.01), ostial location (OR 4.84, 95% CI 1.81 to 12.07; P<0.01), diabetes (OR 2.63, 95% CI 1.14 to 6.31; P=0.02), total stented length (per 10-mm increase; OR 1.42, 95% CI 1.21 to 1.68; P<0.01), reference diameter (per 1.0-mm increase; OR 0.46, 95% CI 0.24 to 0.87; P=0.03), and left anterior descending artery (OR 0.30, 95% CI 0.10 to 0.69; P<0.01). CONCLUSIONS: Angiographic restenosis after SES implantation in complex patients is an infrequent event, occurring mainly in association with lesion-based characteristics and diabetes mellitus. |
| Publication | http://hdl.handle.net/1765/13314 |
| Persistent Identifier | urn:NBN:nl:ui:15-1765/13314 |
| Metadata | XML |
| Repository | Erasmus University Rotterdam |
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