| Title | Clinical management of ovarian small-cell carcinoma of the hypercalcemic type: A proposal for conservative surgery in an advanced stage of disease |
|---|---|
| Published in | International Journal of Gynecological Cancer, Vol. 19, No. 3, p.348-353. ISSN 1048-891x. |
| Author | Dykgraaf, R.H.M.; Jong, de D. (Diederick); Veen, van M. (Mirjam); Ewing-Graham, P.C. (Patricia); Helmerhorst, T.J.M. (Theo); Burg, van der M. (Mirjam) |
| Date | 2009-04-01 |
| Language | English |
| Type | article |
| Abstract | Ovarian small-cell carcinoma of the hypercalcemic type is a rare and highly malignant tumor. In two thirds of the patients, the tumor is associated with asymptomatic paraneoplastic hypercalcemia. The diagnosis may be impeded; the tumor must be distinguished from other tumors with similar features. This tumor occurs predominantly in young women and is merely lethal. The 1-year survival is solely 50%, with an overall 5-year survival rate of approximately 10%. It is believed that the empirical treatment characterized by combination of radical surgery, chemotherapy, and radiotherapy results in the most favorable outcome in terms of survival. However, the outcome remains extremely poor despite this aggressive approach. Alternatively, these poor survival rates may justify a less aggressive fertility sparing approach without compromising the outcome. Such an approach is illustrated by a case report involving a patient with ovarian small-cell carcinoma of the hypercalcemic type, FIGO stage IIIC. A fertility-sparing approach was used, consisting of conservative surgery followed by induction chemotherapy, interval debulking surgery, and local radiotherapy. During follow-up of 60 months, there was no evidence of disease and the normal menstrual cycle resumed. In addition to this case report, histopathological features, different therapeutic modalities, and outcome of ovarian small-cell carcinoma of the hypercalcemic type is reviewed. This report suggests that a fertility-sparing approach may be just as feasible as the generally applied aggressive approach. |
| Publication | http://hdl.handle.net/1765/17153 |
| Persistent Identifier | urn:NBN:nl:ui:15-1765/17153 |
| Metadata | XML |
| Repository | Erasmus University Rotterdam |
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