| Title | Diagnostic accuracy of computed tomography coronary angiography in patients with a zero calcium score |
|---|---|
| Published in | European Radiology: journal of the European Congress of Radiology, Vol. 20, No. 1, p.81-87. ISSN 0938-7994. |
| Author | Cademartiri, F. (Filippo); Maffei, E. (Erica); Palumbo, A. (Alessandro); Martini, C. (Chiara); Seitun, S. (Sara); Tedeschi, C. (Carlo); Rosa, de R. (Roberto); Arcadi, T. (Teresa); Salamone, I. (Ignazio); Blandino, A. (Alfredo); Weustink, A.C. (Annick); Mollet, N.R.A. (Nico); Feyter, de P.J. (Pim); Krestin, G.P. (Gabriel) |
| Date | 2010-01-01 |
| Language | English |
| Type | article |
| Abstract | To evaluate the diagnostic accuracy of 64-slice CT coronary angiography (CT-CA) for the detection of significant coronary artery stenosis in patients with zero on the Agatston Calcium Score (CACS). We enrolled 279 consecutive patients (96 male, mean age 48±12 years) with suspected coronary artery disease. Patients were symptomatic (n=208) or asymptomatic (n=71), and underwent conventional coronary angiography (CAG). For CT-CA we administered an IV bolus of 100 ml of iodinated contrast material. CT-CA was compared to CAG using a threshold for significant stenosis of ≤50%. The prevalence of disease demonstrated at CAG was 15% (1.4% in asymptomatic). The population at CAG showed no or non-significant disease in 85% (238/279), single vessel disease in 9% (25/279), and multi-vessel disease in 6% (16/279). Sensitivity, specificity, and positive and negative predictive values of CT-CA vs. CAG on the patient level were 100%, 95%, 76%, and 100% in the overall population and 100%, 100%, 100%, and 100% in asymptomatic patients, respectively. CT-CA proves high diagnostic performance in patients with or without symptoms and with zero CACS. The prevalence of significant disease detected by CT-CA was not negligible in asymptomatic patients. The role of CT-CA in asymptomatic patients remains uncertain. |
| Publication | http://hdl.handle.net/1765/19568 |
| Persistent Identifier | urn:NBN:nl:ui:15-1765/19568 |
| Metadata | XML |
| Repository | Erasmus University Rotterdam |
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