Giving a patient immunosuppressive medication is creating an environment in which a transplanted organ will be accepted and rejection will be prevented. Unfortunately, the use of immunosuppression is complicated by serious side effects. After dealing
with acute rejection in solid organ transplantation and reducing the incidence of infections in the early days of transplantation, other serious complications became more and more clear. The development of, for example, cardiovascular disease, diabetes mellitus, nephrotoxicity and malignancies after solid organ transplantation is a well known problem for every transplant clinician.