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Measuring microvascular and mitochondrial oxygen tension:... (2011) Open access

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Title Measuring microvascular and mitochondrial oxygen tension: novel techniques for studying tissue oxygenation
Author E.G. Mik
Thesis advisor C.J. Zuurbier; C. Ince
Degree grantor [unknown]
Date 2011-03-01
Reference(s) weefseloxygenatie; zuurstof meten; microvasculaire zuurstofspanning; mitochondriale zuurstofspanning
Language English
Type Doctoral thesis
Abstract This thesis describes the implementation of novel approaches for measuring tissue oxygenation based on oxygen-dependent quenching of the triplet-state lifetime of porphyrins. Ultimately we created a tool for assessment of mitochondrial oxygen tension in vivo. The first measurements indicate much higher mitoPO2 values than generally expected. These findings come in an era of new insights in cellular oxygen sensing and oxygen-dependence of gene expression and metabolism. The described methods are expected to be a valuable addition to the arsenal of tools available to scientist for unraveling the mechanisms of oxygen delivery and consumption under various pathophysiological circumstances. Oxygen is again important, as it has always been …
Publication http://dare.uva.nl/record/368550
Persistent Identifier urn:nbn:nl:ui:29-368550
Metadata XML
Repository University of Amsterdam

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