Malignant transformation of hematopoietic stem cells: pathophysiology and...


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Title Malignant transformation of hematopoietic stem cells: pathophysiology and development of therapy
Period 01 / 1988 - unknown
Status Completed
Research number OND1281057
Data Supplier METIS Erasmus Universiteit Rotterdam


In this project we investigate abnormalities in the cellular responsiveness to hematopoietic growth factors, the expression, structure and function of hematopoie-tic growth factor receptors as well as alterations of signal transduction and transcripti-on that may contribute to the develop-ment of hematological malignancies. The abnormalities may influence the survival, cell cycle regulation, commitment or maturation of hematopoietic progenitor cells. The investiga-ti-ons on the genetic abnormalities of hemato-oncologic diseases extend towards the development of a specific diagnosis and the detection of minimal residual disease, as well as new therapeutic interventions of hematological malignancies. With respect to the development of new treatment strategies aimed at eradicating malignant hematopoietic progenitor cells, we address questions related to their sensitivity to chemotherapy and modulati-on of resistan-ce, the response to novel drugs that target specific genes, experimental approaches of stem cell transplantation and the genetic modificati-on of hematopoietic stem cells. The modalities are explored in relevant animal models as well as in clinical studies.

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Project leader Dr. E. Braakman
Project leader Prof.dr. H.R. Delwel
Project leader Prof.dr. B. Löwenberg
Project leader Prof.dr. P. Sonneveld
Project leader Prof.dr. I.P. Touw
Project leader Prof.dr. G. Wagemaker


D21400 Genetics
D21500 Histology, cell biology
D21800 Immunology, serology
D23120 Oncology
D23220 Internal medicine
D23340 Biopharmacology, toxicology

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