Contrast enhanced magnetic resonance imaging in the valuation of ischemic heart disease
01 / 2001 - 01 / 2004
Contrast enhanced magnetic resonance imaging (MRI) using an extracellular paramagnetic contrast agent is typically divided into dynamic or first pass imaging and steady state or delayed imaging. In first pass MRI the first passage of a contrast agent is tracked through the myocardium which is used for the assessment of myocardial perfusion. In delayed contrast enhanced (DCE) MRI images are acquired more than 5-10 minutes after contrast injection. Areas of hyperenhancement in DCE MRI are presumed to represent irreversibly damaged myocardium. Image quality has improved considerably due to recent technical developments, which has caused renewed interest for the use of contrast enhanced MRI in the evaluation of ischemia and viability in patients with ischemic heart disease. The aims of the present project are: 1. to evaluate DCE MRI as a marker of viability in patients with chronic ischemic left ventricular dysfunction; 2. to evaluate the multislice first pass technique in the assessment of myocardial perfusion in patients with suspected coronary artery disease. The project is divided into two substudies each focusing on one of these two aims. Details of both substudies are provided in separate protocols. The project will result in a thesis for two investigators.