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Growing blood vessels to treat limb ischemia

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Titel Growing blood vessels to treat limb ischemia
Looptijd 01 / 2002 - 01 / 2008
Status Afgesloten
Dissertatie Ja
Onderzoeknummer OND1286718

Samenvatting (EN)

This project aims at improving the circulation in ischemic tissues by gene transfer of VEGF and related factors. The first part of the project deals with mouse studies in which ischemia is induced in the leg and viral vectors containing VEGF and other factors are attributed to the ischemic area. Visualization and quantification of the formation of collateral vessels and evaluation of increased blood flow are the first objectives. Subsequently, the way of application and involvement of different cell types is evaluated. Clinical studies are prepared. The studies are done at TNO Prevention and Health (TNO-PG) and Leiden University Medical Centre (LUMC) in the context of the tripartite angiogenesis program of VUMC - LUMC -TNO-PG.

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Classificatie

A70000 Volksgezondheid en gezondheidszorg
C10000 Biotechnologie
D21400 Genetica
D21700 Fysiologie
D23220 Inwendige geneeskunde

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